GO Term : GO:0003918 DNA topoisomerase type II (ATP-hydrolyzing) activity GO

Namespace  molecular_function Obsolete  false
description  Catalysis of a DNA topological transformation by transiently cleaving a pair of complementary DNA strands to form a gate through which a second double-stranded DNA segment is passed, after which the severed strands in the first DNA segment are rejoined; product release is coupled to ATP binding and hydrolysis; changes the linking number in multiples of 2.

0 Cross References

1 Ontology

Name
GO

14 Parents

Identifier Name Description
GO:0003824 catalytic activity Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic.
GO:0016787 hydrolase activity Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3.
GO:0016887 ATPase activity Catalysis of the reaction: ATP + H2O = ADP + phosphate + 2 H+. May or may not be coupled to another reaction.
GO:0003918 DNA topoisomerase type II (ATP-hydrolyzing) activity Catalysis of a DNA topological transformation by transiently cleaving a pair of complementary DNA strands to form a gate through which a second double-stranded DNA segment is passed, after which the severed strands in the first DNA segment are rejoined; product release is coupled to ATP binding and hydrolysis; changes the linking number in multiples of 2.
GO:0016817 hydrolase activity, acting on acid anhydrides Catalysis of the hydrolysis of any acid anhydride.
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides Catalysis of the hydrolysis of any acid anhydride which contains phosphorus.
GO:0016853 isomerase activity Catalysis of the geometric or structural changes within one molecule. Isomerase is the systematic name for any enzyme of EC class 5.
GO:0008094 DNA-dependent ATPase activity Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction requires the presence of single- or double-stranded DNA, and it drives another reaction.
GO:0003916 DNA topoisomerase activity Catalysis of the transient cleavage and passage of individual DNA strands or double helices through one another, resulting a topological transformation in double-stranded DNA.
GO:0016462 pyrophosphatase activity Catalysis of the hydrolysis of a pyrophosphate bond between two phosphate groups, leaving one phosphate on each of the two fragments.
GO:0003674 molecular_function Elemental activities, such as catalysis or binding, describing the actions of a gene product at the molecular level. A given gene product may exhibit one or more molecular functions.
GO:0017111 nucleoside-triphosphatase activity Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate.
GO:0042623 ATPase activity, coupled Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction directly drives some other reaction, for example ion transport across a membrane.
GO:0061505 DNA topoisomerase II activity Catalysis of a DNA topological transformation by transiently cleaving a pair of complementary DNA strands to form a gate through which a second double-stranded DNA segment is passed, after which the severed strands in the first DNA segment are rejoined; changes the linking number in multiples of 2.

25 Protein

Protein Identifier
Organism . Name
Score Score Type Protein Description Alias (in v1) Code Enzyme Gene Prediction Quality
Qrob_P0016780.2 Quercus robur 0.0 egn (M=6) 2.4.1.242 - NDP-glucose--starch glucosyltransferase.   EC:2.4.1.242 validated
Qrob_P0022510.2 Quercus robur 33.0 egn (M=1) KOG0260//KOG0307//KOG0674//KOG0675//KOG0916//KOG1798//KOG1830//KOG1984//KOG1985//KOG3671 - RNA polymerase II large subunit [Transcription]. // Vesicle coat complex COPII subunit SEC31 [Intracellular trafficking secretion and vesicular transport]. // Calreticulin [Posttranslational modification protein turnover chaperones]. // Calnexin [Posttranslational modification protein turnover chaperones]. // 1 3-beta-glucan synthase/callose synthase catalytic subunit [Cell wall/membrane/envelope biogenesis]. // DNA polymerase epsilon catalytic subunit A [Replication recombination and repair]. // Wiskott Aldrich syndrome proteins [Cytoskeleton]. // Vesicle coat complex COPII subunit SFB3 [Intracellular trafficking secretion and vesicular transport]. // Vesicle coat complex COPII subunit SEC24/subunit SFB2 [Intracellular trafficking secretion and vesicular transport]. // Actin regulatory protein (Wiskott-Aldrich syndrome protein) [Signal transduction mechanisms Cytoskeleton].   EC:6.6.1.1 validated
Qrob_P0034970.2 Quercus robur 32.0 egn (M=1) KOG0260//KOG0307//KOG0674//KOG0675//KOG0916//KOG1798//KOG1984//KOG1985//KOG3671//KOG3753 - RNA polymerase II large subunit [Transcription]. // Vesicle coat complex COPII subunit SEC31 [Intracellular trafficking secretion and vesicular transport]. // Calreticulin [Posttranslational modification protein turnover chaperones]. // Calnexin [Posttranslational modification protein turnover chaperones]. // 1 3-beta-glucan synthase/callose synthase catalytic subunit [Cell wall/membrane/envelope biogenesis]. // DNA polymerase epsilon catalytic subunit A [Replication recombination and repair]. // Vesicle coat complex COPII subunit SFB3 [Intracellular trafficking secretion and vesicular transport]. // Vesicle coat complex COPII subunit SEC24/subunit SFB2 [Intracellular trafficking secretion and vesicular transport]. // Actin regulatory protein (Wiskott-Aldrich syndrome protein) [Signal transduction mechanisms Cytoskeleton]. // Circadian clock protein period [Signal transduction mechanisms].   EC:6.6.1.1 validated
Qrob_P0042900.2 Quercus robur 0.0 egn (M=7) PTHR10169:SF38 - DNA TOPOISOMERASE 2 (PTHR10169:SF38)   EC:5.99.1.3 validated
Qrob_P0050190.2 Quercus robur 0.0 egn (M=6) 2.4.1.242 - NDP-glucose--starch glucosyltransferase.   EC:2.4.1.242 validated
Qrob_P0132040.2 Quercus robur 93.1 egn (M=1) K03163 - DNA topoisomerase I [EC:5.99.1.2]   EC:5.99.1.2 validated
Qrob_P0139160.2 Quercus robur 7.4 egn (M=1) KOG0355//KOG0472//KOG0532//KOG0618//KOG4658 - DNA topoisomerase type II [Chromatin structure and dynamics]. // Leucine-rich repeat protein [Function unknown]. // Leucine-rich repeat (LRR) protein contains calponin homology domain [Cytoskeleton]. // Serine/threonine phosphatase 2C containing leucine-rich repeats similar to SCN circadian oscillatory protein (SCOP) [Signal transduction mechanisms]. // Apoptotic ATPase [Signal transduction mechanisms].     validated
Qrob_P0139240.2 Quercus robur 0.0 egn (M=5) K03164 - DNA topoisomerase II [EC:5.99.1.3]   EC:5.99.1.3 validated
Qrob_P0139260.2 Quercus robur 90.1 egn (M=1) PF00204//PF00521//PF01751 - DNA gyrase B // DNA gyrase/topoisomerase IV, subunit A // Toprim domain   EC:5.99.1.3 validated
Qrob_P0139340.2 Quercus robur 88.1 egn (M=5) K03164 - DNA topoisomerase II [EC:5.99.1.3]   EC:5.99.1.3 validated
Qrob_P0139410.2 Quercus robur 0.0 egn (M=5) K03164 - DNA topoisomerase II [EC:5.99.1.3]   EC:5.99.1.3 validated
Qrob_P0216970.2 Quercus robur 25.0 egn (M=1) KOG0260//KOG0307//KOG0674//KOG0675//KOG0916//KOG1830//KOG1984//KOG1985//KOG3671//KOG3753 - RNA polymerase II large subunit [Transcription]. // Vesicle coat complex COPII subunit SEC31 [Intracellular trafficking secretion and vesicular transport]. // Calreticulin [Posttranslational modification protein turnover chaperones]. // Calnexin [Posttranslational modification protein turnover chaperones]. // 1 3-beta-glucan synthase/callose synthase catalytic subunit [Cell wall/membrane/envelope biogenesis]. // Wiskott Aldrich syndrome proteins [Cytoskeleton]. // Vesicle coat complex COPII subunit SFB3 [Intracellular trafficking secretion and vesicular transport]. // Vesicle coat complex COPII subunit SEC24/subunit SFB2 [Intracellular trafficking secretion and vesicular transport]. // Actin regulatory protein (Wiskott-Aldrich syndrome protein) [Signal transduction mechanisms Cytoskeleton]. // Circadian clock protein period [Signal transduction mechanisms].     validated
Qrob_P0242420.2 Quercus robur 0.0 egn (M=7) PTHR10169:SF38 - DNA TOPOISOMERASE 2 (PTHR10169:SF38)   EC:5.99.1.3 validated
Qrob_P0260970.2 Quercus robur 99.0 egn (M=1) PTHR10848:SF0 - MEIOTIC RECOMBINATION PROTEIN SPO11   EC:5.99.1.3 validated
Qrob_P0384230.2 Quercus robur 74.0 egn (M=1) K02470 - DNA gyrase subunit B [EC:5.99.1.3]   EC:5.99.1.3 validated
Qrob_P0400610.2 Quercus robur 0.0 egn (M=7) PTHR10169:SF38 - DNA TOPOISOMERASE 2 (PTHR10169:SF38)   EC:5.99.1.3 validated
Qrob_P0428560.2 Quercus robur 23.1 egn (M=11) PTHR17630:SF44 - CARBOXYMETHYLENEBUTENOLIDASE HOMOLOG (PTHR17630:SF44)     validated
Qrob_P0432010.2 Quercus robur 10.0 egn (M=2) PTHR10871:SF4 - 30S RIBOSOMAL PROTEIN S13P/S18E   EC:5.99.1.3 validated
Qrob_P0432020.2 Quercus robur 89.0 egn (M=2) PTHR10871:SF4 - 30S RIBOSOMAL PROTEIN S13P/S18E   EC:5.99.1.3 validated
Qrob_P0440380.2 Quercus robur 20.0 egn (M=1) KOG0674//KOG0675//KOG1798 - Calreticulin [Posttranslational modification protein turnover chaperones]. // Calnexin [Posttranslational modification protein turnover chaperones]. // DNA polymerase epsilon catalytic subunit A [Replication recombination and repair].   EC:6.6.1.1 validated
Qrob_P0447740.2 Quercus robur 62.0 egn (M=9) K10878 - meiotic recombination protein SPO11   EC:5.99.1.3 validated
Qrob_P0447760.2 Quercus robur 44.0 egn (M=9) K10878 - meiotic recombination protein SPO11   EC:5.99.1.3 validated
Qrob_P0492230.2 Quercus robur 0.0 egn (M=6) 2.4.1.242 - NDP-glucose--starch glucosyltransferase.   EC:2.4.1.242 validated
Qrob_P0618860.2 Quercus robur 0.0 egn (M=1) PTHR10169//PTHR10169:SF26 - DNA TOPOISOMERASE/GYRASE // SUBFAMILY NOT NAMED   EC:5.99.1.3 validated
Qrob_P0728340.2 Quercus robur 32.0 egn (M=1) PF00521//PF01031 - DNA gyrase/topoisomerase IV, subunit A // Dynamin central region     validated

13 Relations

Relationship
Parent Term . Identifier

Child Term . Identifier
is_a GO:0008094 GO:0003918
is_a GO:0061505 GO:0003918
is_a GO:0016462 GO:0003918
is_a GO:0017111 GO:0003918
is_a GO:0016787 GO:0003918
is_a GO:0003674 GO:0003918
is_a GO:0016887 GO:0003918
is_a GO:0016817 GO:0003918
is_a GO:0016818 GO:0003918
is_a GO:0003824 GO:0003918
is_a GO:0016853 GO:0003918
is_a GO:0003916 GO:0003918
is_a GO:0042623 GO:0003918

11 Synonyms

Name Type
topoisomerase synonym
deoxyribonucleate topoisomerase synonym
DNA-gyrase activity synonym
DNA topoisomerase type II activity synonym
topoisomerase II synonym
type II DNA topoisomerase activity synonym
DNA topoisomerase II synonym
DNA topoisomerase IV activity synonym
DNA gyrase activity synonym
DNA topoisomerase (ATP-hydrolysing) synonym
deoxyribonucleic topoisomerase activity synonym