Protein : Qrob_P0447760.2 Q. robur
Protein Identifier  ? Qrob_P0447760.2 Organism . Name  Quercus robur
Score  44.0 Score Type  egn
Protein Description  (M=9) K10878 - meiotic recombination protein SPO11 Code Enzyme  EC:5.99.1.3
Gene Prediction Quality  validated Protein length 

Sequence

Length: 316  
Kegg Orthology  K10878
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0 Synonyms

8 GO Terms

Identifier Name Description
GO:0003677 DNA binding Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
GO:0005524 ATP binding Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
GO:0003824 catalytic activity Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic.
GO:0003918 DNA topoisomerase type II (ATP-hydrolyzing) activity Catalysis of a DNA topological transformation by transiently cleaving a pair of complementary DNA strands to form a gate through which a second double-stranded DNA segment is passed, after which the severed strands in the first DNA segment are rejoined; product release is coupled to ATP binding and hydrolysis; changes the linking number in multiples of 2.
GO:0006265 DNA topological change The process in which a transformation is induced in the topological structure of a double-stranded DNA helix, resulting in a change in linking number.
GO:0005694 chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information.
GO:0006259 DNA metabolic process Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides.
GO:0000737 DNA catabolic process, endonucleolytic The chemical reactions and pathways resulting in the breakdown of DNA, involving the hydrolysis of internal 3',5'-phosphodiester bonds in one or two strands of deoxyribonucleotides.

33 Blast

Analysis Hit Start End Strand Length Note Hit Coverage Hit Length Hit Pident E Val Hit Description
blastp_kegg lcl|pop:POPTR_0001s37540g 16 309 + 294 Gaps:15 76.44 365 84.59 2e-168 POPTRDRAFT_550198 DNA topoisomerase VIA family protein
blastp_kegg lcl|fve:101293370 16 315 + 300 Gaps:15 78.08 365 79.65 3e-162 meiotic recombination protein SPO11-1-like
blastp_kegg lcl|gmx:100813920 17 311 + 295 Gaps:15 76.29 367 80.00 5e-162 meiotic recombination protein SPO11-1-like
blastp_kegg lcl|pmum:103342724 16 315 + 300 Gaps:15 78.08 365 79.65 2e-160 meiotic recombination protein SPO11-1
blastp_kegg lcl|vvi:100256655 26 310 + 285 Gaps:15 74.79 361 84.07 3e-160 meiotic recombination protein SPO11-1-like
blastp_kegg lcl|pxb:103941907 16 315 + 300 Gaps:16 78.14 366 79.02 5e-159 meiotic recombination protein SPO11-1-like
blastp_kegg lcl|pxb:103965437 16 315 + 300 Gaps:16 78.14 366 79.02 5e-159 meiotic recombination protein SPO11-1-like
blastp_kegg lcl|mdm:103448311 16 315 + 300 Gaps:15 78.08 365 78.60 6e-157 meiotic recombination protein SPO11-1
blastp_kegg lcl|sot:102586801 16 312 + 297 Gaps:15 77.90 362 78.37 7e-157 meiotic recombination protein SPO11-1-like
blastp_kegg lcl|cam:101504128 16 315 + 300 Gaps:18 79.66 354 77.30 2e-155 meiotic recombination protein SPO11-1-like
blastp_pdb 2zbk_G 11 315 + 305 Gaps:45 81.23 389 30.38 8e-34 mol:protein length:389 Type II DNA topoisomerase VI subunit A
blastp_pdb 2zbk_E 11 315 + 305 Gaps:45 81.23 389 30.38 8e-34 mol:protein length:389 Type II DNA topoisomerase VI subunit A
blastp_pdb 2zbk_C 11 315 + 305 Gaps:45 81.23 389 30.38 8e-34 mol:protein length:389 Type II DNA topoisomerase VI subunit A
blastp_pdb 2zbk_A 11 315 + 305 Gaps:45 81.23 389 30.38 8e-34 mol:protein length:389 Type II DNA topoisomerase VI subunit A
blastp_pdb 1d3y_B 20 310 + 291 Gaps:23 93.69 301 29.79 4e-30 mol:protein length:301 DNA TOPOISOMERASE VI A SUBUNIT
blastp_pdb 1d3y_A 20 310 + 291 Gaps:23 93.69 301 29.79 4e-30 mol:protein length:301 DNA TOPOISOMERASE VI A SUBUNIT
blastp_pdb 2q2e_A 23 310 + 288 Gaps:20 75.34 369 25.54 1e-21 mol:protein length:369 Type II DNA topoisomerase VI subunit A
blastp_uniprot_sprot sp|Q9M4A2|SPO11_ARATH 16 313 + 298 Gaps:15 78.18 362 75.97 2e-154 Meiotic recombination protein SPO11-1 OS Arabidopsis thaliana GN SPO11-1 PE 1 SV 1
blastp_uniprot_sprot sp|Q9Y5K1|SPO11_HUMAN 17 312 + 296 Gaps:19 70.96 396 38.08 4e-65 Meiotic recombination protein SPO11 OS Homo sapiens GN SPO11 PE 2 SV 1
blastp_uniprot_sprot sp|Q9WTK8|SPO11_MOUSE 17 312 + 296 Gaps:19 70.96 396 37.37 1e-63 Meiotic recombination protein SPO11 OS Mus musculus GN Spo11 PE 2 SV 2
blastp_uniprot_sprot sp|Q9LZ03|TOP6A_ARATH 15 310 + 296 Gaps:16 65.57 427 38.93 4e-62 DNA topoisomerase 6 subunit A OS Arabidopsis thaliana GN TOP6A PE 1 SV 1
blastp_uniprot_sprot sp|A2XFC1|TOP6A_ORYSI 17 310 + 294 Gaps:16 62.90 442 39.21 2e-58 DNA topoisomerase 6 subunit A OS Oryza sativa subsp. indica GN TOP6A PE 2 SV 2
blastp_uniprot_sprot sp|Q22236|SPO11_CAEEL 16 309 + 294 Gaps:36 64.94 425 35.87 1e-40 Meiotic recombination protein spo-11 OS Caenorhabditis elegans GN spo-11 PE 3 SV 1
blastp_uniprot_sprot sp|Q9M4A1|SPO12_ARATH 20 315 + 296 Gaps:28 73.63 383 35.82 2e-39 Meiotic recombination protein SPO11-2 OS Arabidopsis thaliana GN SPO11-2 PE 1 SV 1
blastp_uniprot_sprot sp|A2BLE8|TOP6A_HYPBU 24 312 + 289 Gaps:41 76.49 387 32.09 5e-39 Type 2 DNA topoisomerase 6 subunit A OS Hyperthermus butylicus (strain DSM 5456 / JCM 9403) GN top6A PE 3 SV 1
blastp_uniprot_sprot sp|Q9YE67|TOP6A_AERPE 24 312 + 289 Gaps:40 76.35 389 31.99 1e-38 Type 2 DNA topoisomerase 6 subunit A OS Aeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1) GN top6A PE 3 SV 2
blastp_uniprot_sprot sp|Q971T1|TOP6A_SULTO 11 315 + 305 Gaps:43 81.14 387 30.25 2e-33 Type 2 DNA topoisomerase 6 subunit A OS Sulfolobus tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7) GN top6A PE 3 SV 1
rpsblast_cdd gnl|CDD|173774 137 299 + 163 Gaps:3 100.00 160 52.50 2e-54 cd00223 TOPRIM_TopoIIB_SPO TOPRIM_TopoIIB_SPO: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in the type IIB family of DNA topoisomerases and Spo11. This subgroup contains proteins similar to Sulfolobus shibatae topoisomerase VI (TopoVI) and Saccharomyces cerevisiae meiotic recombination factor: Spo11. Type II DNA topoisomerases catalyze the ATP-dependent transport of one DNA duplex through another in the process generating transient double strand breaks via covalent attachments to both DNA strands at the 5' positions. TopoVI enzymes are heterotetramers found in archaea and plants. Spo11 plays a role in generating the double strand breaks that initiate homologous recombination during meiosis. S. shibatae TopoVI relaxes both positive and negative supercoils and in addition has a strong decatenase activity. The TOPRIM domain has two conserved motifs one of which centers at a conserved glutamate and the other one at two conserved aspartates (DxD. For topoisomerases the conserved glutamate is believed to act as a general base in strand joining and as a general acid in strand cleavage. The DXD motif may co-ordinate Mg2+ a cofactor required for full catalytic function.
rpsblast_cdd gnl|CDD|31883 18 309 + 292 Gaps:24 78.09 356 36.69 5e-53 COG1697 COG1697 DNA topoisomerase VI subunit A [DNA replication recombination and repair].
rpsblast_cdd gnl|CDD|179833 18 312 + 295 Gaps:33 78.47 367 30.56 4e-52 PRK04342 PRK04342 DNA topoisomerase VI subunit A Provisional.

17 Domain Motifs

Analysis Begin End Length Domain Identifier Cross Ref Description Inter Pro
PRINTS 169 189 21 PR01552 none DNA topoisomerase VI subunit A (TOP6A) signature IPR004085
PRINTS 286 309 24 PR01552 none DNA topoisomerase VI subunit A (TOP6A) signature IPR004085
PRINTS 45 62 18 PR01552 none DNA topoisomerase VI subunit A (TOP6A) signature IPR004085
PRINTS 37 48 12 PR01550 none DNA topoisomerase VI subunit A family signature IPR002815
PRINTS 69 84 16 PR01550 none DNA topoisomerase VI subunit A family signature IPR002815
PRINTS 163 184 22 PR01550 none DNA topoisomerase VI subunit A family signature IPR002815
PRINTS 195 211 17 PR01550 none DNA topoisomerase VI subunit A family signature IPR002815
PRINTS 51 68 18 PR01550 none DNA topoisomerase VI subunit A family signature IPR002815
PRINTS 139 156 18 PR01550 none DNA topoisomerase VI subunit A family signature IPR002815
PANTHER 96 315 220 PTHR10848 none none IPR002815
PANTHER 16 75 60 PTHR10848 none none IPR002815
SUPERFAMILY 17 311 295 SSF56726 none none IPR002815
Pfam 18 75 58 PF04406 none Type IIB DNA topoisomerase IPR013049
Gene3D 96 311 216 G3DSA:3.40.1360.10 none none none
PANTHER 96 315 220 PTHR10848:SF3 none none none
PANTHER 16 75 60 PTHR10848:SF3 none none none
Gene3D 19 75 57 G3DSA:1.10.10.10 none none IPR011991

0 Localization

8 Qtllist

Qtl Name Chromosome Name Linkage Group Prox Marker Dist Marker Position QTL Pos One Pos Two Test Type Test Value R 2
Bourran2_2014_nSecLBD_3P Qrob_Chr08 8 s_1BN2OD_551 s_1B5AYF_599 17,17 0 43,51 lod 1,9229 4,4
Bourran2_2015_nEpiBC_3P Qrob_Chr12 12 s_1B73S5_217 v_7050_211 28,31 26,37 28,45 lod 4.5 11.6
Bourran2_2014_nLBD*_3P Qrob_Chr08 8 v_5216_549 v_11837_70 12,25 0 35,55 lod 2,5951 6
Bourran2_2014_nP*_3P Qrob_Chr08 8 v_5216_549 v_11837_70 12,19 0 31,97 lod 2,8472 6
Bourran2_2014_nPriLBD_3P Qrob_Chr08 8 v_5216_549 v_11837_70 12,36 0 30,43 lod 2,5806 5,1
Champenoux_2015_nSeqBC_A4 Qrob_Chr08 8 v_AD7YD13_501 s_1A7IED_780 43,44 43,42 43,99 lod 3.7 8.9
Bourran2_2014_nEpis*_3P Qrob_Chr08 8 s_1DA4QW_688 s_1DNI7D_820 17,96 0 37,75 lod 2,9745 7,5
Bourran2_2014_nPriBD_3P Qrob_Chr11 11 v_11486_194 s_1AT3E_2335 5,54 0,4 20,6 lod 2,6345 5,9

0 Targeting