GO Term : GO:0004222 metalloendopeptidase activity GO

Namespace  molecular_function Obsolete  false
description  Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions.

0 Cross References

1 Ontology

Name
GO

8 Parents

Identifier Name Description
GO:0003824 catalytic activity Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic.
GO:0016787 hydrolase activity Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3.
GO:0004222 metalloendopeptidase activity Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions.
GO:0008237 metallopeptidase activity Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions.
GO:0008233 peptidase activity Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid.
GO:0004175 endopeptidase activity Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain.
GO:0003674 molecular_function Elemental activities, such as catalysis or binding, describing the actions of a gene product at the molecular level. A given gene product may exhibit one or more molecular functions.
GO:0070011 peptidase activity, acting on L-amino acid peptides Catalysis of the hydrolysis of peptide bonds formed between L-amino acids.

46 Protein

Protein Identifier
Organism . Name
Score Score Type Protein Description Alias (in v1) Code Enzyme Gene Prediction Quality
Qrob_P0007330.2 Quercus robur 100.0 egn (M=2) PTHR23076:SF54 - ATP-DEPENDENT ZINC METALLOPROTEASE FTSH 6, CHLOROPLASTIC (PTHR23076:SF54)     validated
Qrob_P0017390.2 Quercus robur 92.1 egn (M=1) PTHR11735:SF12 - TRNA N6-ADENOSINE THREONYLCARBAMOYLTRANSFERASE, MITOCHONDRIAL-RELATED (PTHR11735:SF12)   EC:2.6.99.4 validated
Qrob_P0018310.2 Quercus robur 100.0 egn (M=7) 3.4.24.12 - Envelysin.   EC:3.4.24.12 validated
Qrob_P0019960.2 Quercus robur 99.0 egn (M=1) 3.4.24.16 - Neurolysin.   EC:3.4.24.16 validated
Qrob_P0057370.2 Quercus robur 100.0 egn (M=3) 3.4.24.7 - Interstitial collagenase.   EC:3.4.24.7 validated
Qrob_P0057390.2 Quercus robur 100.0 egn (M=1) 3.4.24.22 - Stromelysin 2.   EC:3.4.24.22 validated
Qrob_P0079220.2 Quercus robur 100.0 egn (M=2) 3.4.24.84 - Ste24 endopeptidase.   EC:3.4.24.84 validated
Qrob_P0111110.2 Quercus robur 99.1 egn (M=7) 3.4.24.12 - Envelysin.   EC:3.4.24.12 validated
Qrob_P0120420.2 Quercus robur 94.0 egn (M=1) PF02163 - Peptidase family M50     validated
Qrob_P0120660.2 Quercus robur 100.0 egn (M=1) PTHR23076//PTHR23076:SF47 - METALLOPROTEASE M41 FTSH // SUBFAMILY NOT NAMED     validated
Qrob_P0121110.2 Quercus robur 94.0 egn (M=1) K18156 - mitochondrial inner membrane protease ATP23 [EC:3.4.24.-]     validated
Qrob_P0138660.2 Quercus robur 72.1 egn (M=1) PTHR23076:SF49 - AAA-TYPE ATPASE FAMILY PROTEIN (PTHR23076:SF49)     validated
Qrob_P0204930.2 Quercus robur 69.5 egn (M=1) PTHR23076:SF33 - ATP-DEPENDENT ZINC METALLOPROTEASE FTSH 1, CHLOROPLASTIC-RELATED (PTHR23076:SF33)     validated
Qrob_P0226580.2 Quercus robur 98.1 egn (M=1) PTHR11851//PTHR11851:SF107 - METALLOPROTEASE // SUBFAMILY NOT NAMED   EC:3.4.21.102 validated
Qrob_P0231260.2 Quercus robur 100.0 egn (M=1) K17732 - mitochondrial-processing peptidase subunit beta [EC:3.4.24.64]     validated
Qrob_P0242500.2 Quercus robur 100.0 egn (M=7) 3.4.24.12 - Envelysin.   EC:3.4.24.12 validated
Qrob_P0280040.2 Quercus robur 100.0 egn (M=1) K01411 - nardilysin [EC:3.4.24.61]   EC:3.4.24.56 validated
Qrob_P0296720.2 Quercus robur 0.0 egn (M=2) 3.4.24.23 - Matrilysin.   EC:3.4.24.23 validated
Qrob_P0321670.2 Quercus robur 75.0 egn (M=1) K08955 - ATP-dependent metalloprotease [EC:3.4.24.-]     validated
Qrob_P0322870.2 Quercus robur 100.0 egn (M=1) PTHR23076//PTHR23076:SF39 - METALLOPROTEASE M41 FTSH // SUBFAMILY NOT NAMED     validated
Qrob_P0357150.2 Quercus robur 100.0 egn (M=1) PTHR23076:SF56 - AAA-TYPE ATPASE FAMILY PROTEIN (PTHR23076:SF56)     validated
Qrob_P0361780.2 Quercus robur 58.3 egn (M=3) PTHR23076:SF58 - FTSH EXTRACELLULAR PROTEASE FAMILY PROTEIN (PTHR23076:SF58)     validated
Qrob_P0388940.2 Quercus robur 0.0 egn (M=2) 3.4.24.84 - Ste24 endopeptidase.   EC:3.4.24.84 validated
Qrob_P0409770.2 Quercus robur 100.0 egn (M=2) 3.4.24.34 - Neutrophil collagenase.   EC:3.4.24.34 validated
Qrob_P0409780.2 Quercus robur 90.8 egn (M=7) 3.4.24.12 - Envelysin.   EC:3.4.24.12 validated
Qrob_P0409790.2 Quercus robur 0.0 egn (M=7) 3.4.24.12 - Envelysin.   EC:3.4.24.12 validated
Qrob_P0415370.2 Quercus robur 19.1 egn (M=2) PTHR22726 - OMA1 HOMOLOG, ZINC METALLOPEPTIDASE     validated
Qrob_P0420900.2 Quercus robur 100.0 egn (M=1) PTHR10120//PTHR10120:SF21 - CAAX PRENYL PROTEASE 1 // SUBFAMILY NOT NAMED (PTHR10120:SF21)     validated
Qrob_P0507430.2 Quercus robur 0.0 egn (M=1) KOG0959//KOG0961 - N-arginine dibasic convertase NRD1 and related Zn2+-dependent endopeptidases insulinase superfamily [Posttranslational modification protein turnover chaperones]. // Predicted Zn2+-dependent endopeptidase insulinase superfamily [Posttranslational modification protein turnover chaperones].   EC:3.4.24.56 validated
Qrob_P0520530.2 Quercus robur 83.2 egn (M=2) K08956 - AFG3 family protein [EC:3.4.24.-]     validated

8 Relations

Relationship
Parent Term . Identifier

Child Term . Identifier
is_a GO:0008237 GO:0004222
is_a GO:0004175 GO:0004222
is_a GO:0003824 GO:0004222
is_a GO:0016787 GO:0004222
is_a GO:0008233 GO:0004222
is_a GO:0003674 GO:0004222
is_a GO:0070011 GO:0004222
is_a GO:0004222 GO:1902945

2 Synonyms

Name Type
metalloendoproteinase activity synonym
metalloendoprotease activity synonym