GO Term : GO:0016592 mediator complex GO

Namespace  cellular_component Obsolete  false
description  A protein complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and plays an active role in transducing the signal from a transcription factor to the transcriptional machinery. The mediator complex is required for activation of transcription of most protein-coding genes, but can also act as a transcriptional corepressor. The Saccharomyces complex contains several identifiable subcomplexes: a head domain comprising Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p; and a regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Metazoan mediator complexes have similar modular structures and include homologs of yeast Srb and Med proteins.

0 Cross References

1 Ontology

Name
GO

22 Parents

Identifier Name Description
GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm.
GO:0016592 mediator complex A protein complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and plays an active role in transducing the signal from a transcription factor to the transcriptional machinery. The mediator complex is required for activation of transcription of most protein-coding genes, but can also act as a transcriptional corepressor. The Saccharomyces complex contains several identifiable subcomplexes: a head domain comprising Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p; and a regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Metazoan mediator complexes have similar modular structures and include homologs of yeast Srb and Med proteins.
GO:0043234 protein complex A stable macromolecular complex composed (only) of two or more polypeptide subunits along with any covalently attached molecules (such as lipid anchors or oligosaccharide) or non-protein prosthetic groups (such as nucleotides or metal ions). Prosthetic group in this context refers to a tightly bound cofactor. The component polypeptide subunits may be identical.
GO:0043231 intracellular membrane-bounded organelle Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.
GO:0044424 intracellular part Any constituent part of the living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm.
GO:0005623 cell The basic structural and functional unit of all organisms. Includes the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope.
GO:0032991 macromolecular complex A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which the constituent parts function together.
GO:0044464 cell part Any constituent part of a cell, the basic structural and functional unit of all organisms.
GO:0005575 cellular_component The part of a cell or its extracellular environment in which a gene product is located. A gene product may be located in one or more parts of a cell and its location may be as specific as a particular macromolecular complex, that is, a stable, persistent association of macromolecules that function together.
GO:0044428 nuclear part Any constituent part of the nucleus, a membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated.
GO:0044422 organelle part Any constituent part of an organelle, an organized structure of distinctive morphology and function. Includes constituent parts of the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton, but excludes the plasma membrane.
GO:0044446 intracellular organelle part A constituent part of an intracellular organelle, an organized structure of distinctive morphology and function, occurring within the cell. Includes constituent parts of the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton but excludes the plasma membrane.
GO:0043226 organelle Organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton, and prokaryotic structures such as anammoxosomes and pirellulosomes. Excludes the plasma membrane.
GO:0043227 membrane-bounded organelle Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.
GO:0043229 intracellular organelle Organized structure of distinctive morphology and function, occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane.
GO:0044451 nucleoplasm part Any constituent part of the nucleoplasm, that part of the nuclear content other than the chromosomes or the nucleolus.
GO:0043233 organelle lumen The internal volume enclosed by the membranes of a particular organelle; includes the volume enclosed by a single organelle membrane, e.g. endoplasmic reticulum lumen, or the volume enclosed by the innermost of the two lipid bilayers of an organelle envelope, e.g. nuclear lumen.
GO:0031981 nuclear lumen The volume enclosed by the nuclear inner membrane.
GO:0070013 intracellular organelle lumen An organelle lumen that is part of an intracellular organelle.
GO:0005654 nucleoplasm That part of the nuclear content other than the chromosomes or the nucleolus.
GO:0031974 membrane-enclosed lumen The enclosed volume within a sealed membrane or between two sealed membranes. Encompasses the volume enclosed by the membranes of a particular organelle, e.g. endoplasmic reticulum lumen, or the space between the two lipid bilayers of a double membrane surrounding an organelle, e.g. nuclear envelope lumen.

12 Protein

Protein Identifier
Organism . Name
Score Score Type Protein Description Alias (in v1) Code Enzyme Gene Prediction Quality
Qrob_P0033990.2 Quercus robur 100.0 egn (M=1) PTHR22795 - SUPPRESSOR OF RNA POLYMERASE B SRB8-RELATED     validated
Qrob_P0155820.2 Quercus robur 100.0 egn (M=2) K15139 - mediator of RNA polymerase II transcription subunit 22     validated
Qrob_P0178300.2 Quercus robur 100.0 egn (M=1) K15151 - mediator of RNA polymerase II transcription subunit 10     validated
Qrob_P0260690.2 Quercus robur 100.0 egn (M=1) K15131 - mediator of RNA polymerase II transcription subunit 11     validated
Qrob_P0261030.2 Quercus robur 100.0 egn (M=1) PTHR13208 - MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 4     validated
Qrob_P0455030.2 Quercus robur 100.0 egn (M=2) K15128 - mediator of RNA polymerase II transcription subunit 6     validated
Qrob_P0474750.2 Quercus robur 62.3 egn (M=2) K15148 - mediator of RNA polymerase II transcription subunit 7     validated
Qrob_P0474790.2 Quercus robur 95.1 egn (M=2) K15148 - mediator of RNA polymerase II transcription subunit 7     validated
Qrob_P0484720.2 Quercus robur 100.0 egn (M=1) K15156 - mediator of RNA polymerase II transcription subunit 14     validated
Qrob_P0491730.2 Quercus robur 100.0 egn (M=1) PTHR13104//PTHR13104:SF0 - MED-6-RELATED // SUBFAMILY NOT NAMED     validated
Qrob_P0514150.2 Quercus robur 86.2 egn (M=1) K15153 - mediator of RNA polymerase II transcription subunit 31     validated
Qrob_P0582260.2 Quercus robur 100.0 egn (M=2) K15139 - mediator of RNA polymerase II transcription subunit 22     validated

27 Relations

Relationship
Parent Term . Identifier

Child Term . Identifier
is_a GO:0043234 GO:0016592
is_a GO:0044451 GO:0016592
part of GO:0070013 GO:0016592
part of GO:0031981 GO:0016592
part of GO:0044428 GO:0016592
is_a GO:0005575 GO:0016592
is_a GO:0044424 GO:0016592
part of GO:0005654 GO:0016592
part of GO:0043231 GO:0016592
is_a GO:0044422 GO:0016592
part of GO:0043233 GO:0016592
part of GO:0005623 GO:0016592
is_a GO:0044428 GO:0016592
is_a GO:0044446 GO:0016592
part of GO:0043226 GO:0016592
part of GO:0005634 GO:0016592
part of GO:0005622 GO:0016592
part of GO:0044464 GO:0016592
part of GO:0043227 GO:0016592
part of GO:0043229 GO:0016592
is_a GO:0032991 GO:0016592
part of GO:0005575 GO:0016592
part of GO:0031974 GO:0016592
part of GO:0044446 GO:0016592
part of GO:0044424 GO:0016592
is_a GO:0044464 GO:0016592
part of GO:0044422 GO:0016592

5 Synonyms

Name Type
GO:0000119 alt_id
TRAP complex synonym
CDK8-containing TRAP/mediator complex synonym
Srb-mediator complex synonym
L mediator complex synonym