Protein : Qrob_P0455030.2 Q. robur
Protein Identifier  ? Qrob_P0455030.2 Organism . Name  Quercus robur
Score  100.0 Score Type  egn
Protein Description  (M=2) K15128 - mediator of RNA polymerase II transcription subunit 6 Gene Prediction Quality  validated
Protein length 

Sequence

Length: 253  
Kegg Orthology  K15128
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0 Synonyms

3 GO Terms

Identifier Name Description
GO:0001104 RNA polymerase II transcription cofactor activity Interacting selectively and non-covalently with an RNA polymerase II (RNAP II) regulatory transcription factor and also with the RNAP II basal transcription machinery in order to modulate transcription. Cofactors generally do not bind DNA, but rather mediate protein-protein interactions between regulatory transcription factors and the basal RNAP II transcription machinery.
GO:0006357 regulation of transcription from RNA polymerase II promoter Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter.
GO:0016592 mediator complex A protein complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and plays an active role in transducing the signal from a transcription factor to the transcriptional machinery. The mediator complex is required for activation of transcription of most protein-coding genes, but can also act as a transcriptional corepressor. The Saccharomyces complex contains several identifiable subcomplexes: a head domain comprising Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p; and a regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Metazoan mediator complexes have similar modular structures and include homologs of yeast Srb and Med proteins.

26 Blast

Analysis Hit Start End Strand Length Note Hit Coverage Hit Length Hit Pident E Val Hit Description
blastp_kegg lcl|rcu:RCOM_1486710 25 252 + 228 none 90.84 251 85.96 2e-137 RNA polymerase II mediator complex subunit putative
blastp_kegg lcl|vvi:100253150 1 252 + 252 Gaps:3 98.06 258 81.42 5e-135 putative mediator of RNA polymerase II transcription subunit 6-like
blastp_kegg lcl|pper:PRUPE_ppa010369mg 1 252 + 252 Gaps:8 100.00 252 82.94 3e-134 hypothetical protein
blastp_kegg lcl|pmum:103342864 1 252 + 252 Gaps:8 100.00 252 82.94 3e-134 mediator of RNA polymerase II transcription subunit 6
blastp_kegg lcl|pvu:PHAVU_010G143300g 1 252 + 252 Gaps:7 100.00 247 81.38 3e-133 hypothetical protein
blastp_kegg lcl|cmo:103489986 16 252 + 237 Gaps:3 92.55 255 85.17 5e-132 mediator of RNA polymerase II transcription subunit 6
blastp_kegg lcl|tcc:TCM_028940 25 252 + 228 Gaps:1 89.11 257 83.41 3e-131 RNA polymerase transcriptional regulation mediator-related isoform 1
blastp_kegg lcl|csv:101216910 16 252 + 237 Gaps:6 91.92 260 83.68 1e-129 mediator of RNA polymerase II transcription subunit 6-like
blastp_kegg lcl|csv:101229093 28 252 + 225 Gaps:2 98.67 226 86.10 4e-129 mediator of RNA polymerase II transcription subunit 6-like
blastp_kegg lcl|gmx:100792248 26 252 + 227 Gaps:4 91.67 252 80.95 7e-129 mediator of RNA polymerase II transcription subunit 6-like
blastp_pdb 3rj1_U 38 151 + 114 Gaps:58 57.63 295 28.24 1e-13 mol:protein length:295 Mediator of RNA polymerase II transcription s
blastp_pdb 3rj1_N 38 151 + 114 Gaps:58 57.63 295 28.24 1e-13 mol:protein length:295 Mediator of RNA polymerase II transcription s
blastp_pdb 3rj1_G 38 151 + 114 Gaps:58 57.63 295 28.24 1e-13 mol:protein length:295 Mediator of RNA polymerase II transcription s
blastp_uniprot_sprot sp|F4IXJ7|MED6_ARATH 24 252 + 229 Gaps:43 90.60 298 62.96 5e-102 Mediator of RNA polymerase II transcription subunit 6 OS Arabidopsis thaliana GN MED6 PE 1 SV 1
blastp_uniprot_sprot sp|Q54PN3|MED6_DICDI 27 211 + 185 Gaps:9 70.41 267 40.43 4e-34 Putative mediator of RNA polymerase II transcription subunit 6 OS Dictyostelium discoideum GN med6 PE 3 SV 1
blastp_uniprot_sprot sp|Q3SZY9|MED6_BOVIN 27 237 + 211 Gaps:36 93.90 246 37.23 4e-30 Mediator of RNA polymerase II transcription subunit 6 OS Bos taurus GN MED6 PE 2 SV 1
blastp_uniprot_sprot sp|Q7Q107|MED6_ANOGA 12 220 + 209 Gaps:23 82.40 267 39.09 1e-29 Mediator of RNA polymerase II transcription subunit 6 OS Anopheles gambiae GN MED6 PE 3 SV 3
blastp_uniprot_sprot sp|Q921D4|MED6_MOUSE 27 225 + 199 Gaps:16 83.33 246 38.05 1e-29 Mediator of RNA polymerase II transcription subunit 6 OS Mus musculus GN Med6 PE 2 SV 2
blastp_uniprot_sprot sp|O75586|MED6_HUMAN 27 202 + 176 Gaps:16 73.98 246 39.56 4e-29 Mediator of RNA polymerase II transcription subunit 6 OS Homo sapiens GN MED6 PE 1 SV 2
blastp_uniprot_sprot sp|Q8MSX2|MED6_DROME 49 220 + 172 Gaps:23 74.30 249 39.46 5e-29 Mediator of RNA polymerase II transcription subunit 6 OS Drosophila melanogaster GN MED6 PE 1 SV 1
blastp_uniprot_sprot sp|Q5RD94|MED6_PONAB 27 202 + 176 Gaps:16 73.98 246 39.01 1e-28 Mediator of RNA polymerase II transcription subunit 6 OS Pongo abelii GN MED6 PE 2 SV 1
blastp_uniprot_sprot sp|Q6IQ63|MED6_DANRE 27 203 + 177 Gaps:16 72.05 254 36.61 2e-26 Mediator of RNA polymerase II transcription subunit 6 OS Danio rerio GN med6 PE 2 SV 1
blastp_uniprot_sprot sp|Q6CTT6|MED6_KLULA 33 171 + 139 Gaps:46 66.04 268 30.51 1e-19 Mediator of RNA polymerase II transcription subunit 6 OS Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) GN MED6 PE 3 SV 1
rpsblast_cdd gnl|CDD|203126 31 156 + 126 Gaps:2 95.52 134 48.44 3e-47 pfam04934 Med6 MED6 mediator sub complex component. Component of RNA polymerase II holoenzyme and mediator sub complex.
rpsblast_cdd gnl|CDD|34700 25 152 + 128 Gaps:5 63.33 210 33.83 2e-25 COG5097 MED6 RNA polymerase II transcriptional regulation mediator [Transcription].
rpsblast_kog gnl|CDD|38379 24 159 + 136 Gaps:2 66.35 208 39.86 6e-32 KOG3169 KOG3169 KOG3169 RNA polymerase II transcriptional regulation mediator [Transcription].

3 Domain Motifs

Analysis Begin End Length Domain Identifier Cross Ref Description Inter Pro
PANTHER 17 252 236 PTHR13104 none none IPR007018
Pfam 31 155 125 PF04934 none MED6 mediator sub complex component IPR007018
PIRSF 16 252 237 PIRSF023869 none none IPR016820

0 Localization

5 Qtllist

Qtl Name Chromosome Name Linkage Group Prox Marker Dist Marker Position QTL Pos One Pos Two Test Type Test Value R 2
Bourran2_2015_nEpiBC_3P Qrob_Chr12 12 s_1B73S5_217 v_7050_211 28,31 26,37 28,45 lod 4.5 11.6
Bourran2_2014_aSeqBC_A4 Qrob_Chr08 8 v_15999_278 v_AP13YL15_395 32,52 4,22 57,22 lod 2,7561 6,7
Bourran2_2014_nFork*_A4 Qrob_Chr08 8 PIE175 s_1CD7GJ_1398 31,22 5,24 57,24 lod 2,6724 6,8
Champenoux_2015_nSeqBC_A4 Qrob_Chr08 8 v_AD7YD13_501 s_1A7IED_780 43,44 43,42 43,99 lod 3.7 8.9
NancyGreenhouseCO2_2001_ambient_elevated_leaf_cellulose_QTL3_d13Cf Qrob_Chr08 8 v_5216_549 v_11625_20 37.08 12,26 54,9 lod 6.5888 0.04

0 Targeting