Protein : Qrob_P0484720.2 Q. robur
Protein Identifier  ? Qrob_P0484720.2 Organism . Name  Quercus robur
Score  100.0 Score Type  egn
Protein Description  (M=1) K15156 - mediator of RNA polymerase II transcription subunit 14 Gene Prediction Quality  validated
Protein length 

Sequence

Length: 1848  
Kegg Orthology  K15156
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0 Synonyms

3 GO Terms

Identifier Name Description
GO:0001104 RNA polymerase II transcription cofactor activity Interacting selectively and non-covalently with an RNA polymerase II (RNAP II) regulatory transcription factor and also with the RNAP II basal transcription machinery in order to modulate transcription. Cofactors generally do not bind DNA, but rather mediate protein-protein interactions between regulatory transcription factors and the basal RNAP II transcription machinery.
GO:0006357 regulation of transcription from RNA polymerase II promoter Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter.
GO:0016592 mediator complex A protein complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and plays an active role in transducing the signal from a transcription factor to the transcriptional machinery. The mediator complex is required for activation of transcription of most protein-coding genes, but can also act as a transcriptional corepressor. The Saccharomyces complex contains several identifiable subcomplexes: a head domain comprising Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p; and a regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Metazoan mediator complexes have similar modular structures and include homologs of yeast Srb and Med proteins.

22 Blast

Analysis Hit Start End Strand Length Note Hit Coverage Hit Length Hit Pident E Val Hit Description
blastp_kegg lcl|pmum:103318641 1 1847 + 1847 Gaps:59 100.00 1842 80.29 0.0 mediator of RNA polymerase II transcription subunit 14
blastp_kegg lcl|pxb:103954395 1 1847 + 1847 Gaps:56 100.00 1815 80.00 0.0 mediator of RNA polymerase II transcription subunit 14
blastp_kegg lcl|cic:CICLE_v10000014mg 4 1844 + 1841 Gaps:64 99.73 1820 80.28 0.0 hypothetical protein
blastp_kegg lcl|cit:102616264 4 1844 + 1841 Gaps:64 99.73 1820 80.28 0.0 mediator of RNA polymerase II transcription subunit 14-like
blastp_kegg lcl|mdm:103434166 1 1847 + 1847 Gaps:60 100.00 1811 79.57 0.0 mediator of RNA polymerase II transcription subunit 14
blastp_kegg lcl|mdm:103430508 1 1833 + 1833 Gaps:55 100.00 1802 79.91 0.0 mediator of RNA polymerase II transcription subunit 14-like
blastp_kegg lcl|tcc:TCM_026345 4 1827 + 1824 Gaps:43 99.56 1813 80.44 0.0 Mediator of RNA polymerase II transcription subunit 14
blastp_kegg lcl|vvi:100267561 3 1847 + 1845 Gaps:110 99.94 1758 81.84 0.0 uncharacterized LOC100267561
blastp_kegg lcl|pvu:PHAVU_006G101900g 1 1847 + 1847 Gaps:52 100.00 1815 76.42 0.0 hypothetical protein
blastp_kegg lcl|gmx:100783484 1 1847 + 1847 Gaps:59 100.00 1806 76.58 0.0 mediator of RNA polymerase II transcription subunit 14-like
blastp_uniprot_sprot sp|Q9SR02|MED14_ARATH 4 1838 + 1835 Gaps:189 99.12 1703 70.56 0.0 Mediator of RNA polymerase II transcription subunit 14 OS Arabidopsis thaliana GN MED14 PE 1 SV 1
blastp_uniprot_sprot sp|P0CB66|MED14_DICDI 63 548 + 486 Gaps:90 35.77 1420 29.13 3e-42 Putative mediator of RNA polymerase II transcription subunit 14 OS Dictyostelium discoideum GN med14 PE 3 SV 1
blastp_uniprot_sprot sp|O60244|MED14_HUMAN 63 307 + 245 Gaps:5 17.19 1454 30.00 6e-31 Mediator of RNA polymerase II transcription subunit 14 OS Homo sapiens GN MED14 PE 1 SV 2
blastp_uniprot_sprot sp|A2ABV5|MED14_MOUSE 63 314 + 252 Gaps:5 17.61 1459 29.57 1e-30 Mediator of RNA polymerase II transcription subunit 14 OS Mus musculus GN Med14 PE 1 SV 1
blastp_uniprot_sprot sp|Q03570|MED14_CAEEL 61 307 + 247 Gaps:7 16.75 1516 31.89 2e-28 Mediator of RNA polymerase II transcription subunit 14 OS Caenorhabditis elegans GN rgr-1 PE 3 SV 6
blastp_uniprot_sprot sp|Q61IR6|MED14_CAEBR 61 307 + 247 Gaps:7 16.49 1540 30.71 4e-26 Mediator of RNA polymerase II transcription subunit 14 OS Caenorhabditis briggsae GN rgr-1 PE 3 SV 3
blastp_uniprot_sprot sp|Q29FF7|MED14_DROPS 63 302 + 240 Gaps:5 15.85 1546 29.80 4e-26 Mediator of RNA polymerase II transcription subunit 14 OS Drosophila pseudoobscura pseudoobscura GN MED14 PE 3 SV 2
blastp_uniprot_sprot sp|Q9W0P8|MED14_DROME 63 302 + 240 Gaps:5 15.78 1553 28.98 4e-25 Mediator of RNA polymerase II transcription subunit 14 OS Drosophila melanogaster GN MED14 PE 1 SV 4
blastp_uniprot_sprot sp|Q16U49|MED14_AEDAE 63 425 + 363 Gaps:39 21.67 1578 25.73 2e-23 Mediator of RNA polymerase II transcription subunit 14 OS Aedes aegypti GN MED14 PE 3 SV 2
blastp_uniprot_sprot sp|Q7Q6S8|MED14_ANOGA 63 425 + 363 Gaps:39 20.87 1639 25.15 2e-23 Mediator of RNA polymerase II transcription subunit 14 OS Anopheles gambiae GN MED14 PE 3 SV 5
rpsblast_cdd gnl|CDD|192107 8 223 + 216 Gaps:25 100.00 195 32.31 7e-44 pfam08638 Med14 Mediator complex subunit MED14. Saccharomyces cerevisiae RGR1 mediator complex subunit affects chromatin structure transcriptional regulation of diverse genes and sporulation required for glucose repression HO repression RME1 repression and sporulation. This subunit is also found in higher eukaryotes and Med14 is the agreed unified nomenclature for this subunit. Med14 is found in the tail region of Mediator.
rpsblast_kog gnl|CDD|37086 14 1706 + 1693 Gaps:287 86.46 1322 27.12 1e-111 KOG1875 KOG1875 KOG1875 Thyroid hormone receptor-associated coactivator complex component (TRAP170) [Transcription].

20 Domain Motifs

Analysis Begin End Length Domain Identifier Cross Ref Description Inter Pro
Phobius 584 1179 596 CYTOPLASMIC_DOMAIN none Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm. none
PANTHER 448 666 219 PTHR12809 none none none
PANTHER 4 33 30 PTHR12809 none none none
PANTHER 448 666 219 PTHR12809:SF2 none none none
PANTHER 58 314 257 PTHR12809:SF2 none none none
PANTHER 341 432 92 PTHR12809:SF2 none none none
Phobius 565 583 19 TRANSMEMBRANE none Region of a membrane-bound protein predicted to be embedded in the membrane. none
PANTHER 1427 1847 421 PTHR12809:SF2 none none none
PANTHER 837 1078 242 PTHR12809 none none none
PANTHER 58 314 257 PTHR12809 none none none
PANTHER 837 1078 242 PTHR12809:SF2 none none none
PANTHER 1427 1847 421 PTHR12809 none none none
PANTHER 1109 1407 299 PTHR12809 none none none
Phobius 1180 1200 21 TRANSMEMBRANE none Region of a membrane-bound protein predicted to be embedded in the membrane. none
PANTHER 1109 1407 299 PTHR12809:SF2 none none none
Phobius 1 564 564 NON_CYTOPLASMIC_DOMAIN none Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region. none
PANTHER 341 432 92 PTHR12809 none none none
Phobius 1201 1847 647 NON_CYTOPLASMIC_DOMAIN none Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region. none
PANTHER 4 33 30 PTHR12809:SF2 none none none
Pfam 9 221 213 PF08638 none Mediator complex subunit MED14 IPR013947

0 Localization

7 Qtllist

Qtl Name Chromosome Name Linkage Group Prox Marker Dist Marker Position QTL Pos One Pos Two Test Type Test Value R 2
Bourran2_2014_nLBD*_A4 Qrob_Chr08 8 v_12498_318 v_12364_308 34,91 16,12 53,62 lod 2,4961 5,2
Bourran2_2014_rEpiBC*_A4 Qrob_Chr08 8 v_12498_318 v_12364_308 35,77 14,11 55,31 lod 2,9413 6,2
Bourran_2000_2002_QTL6_Delta.F Qrob_Chr03 3 s_2HYXJ2_207 s_1AUAXK_317 29.12 6,3 45,37 lod 3.1666 0.026
Bourran2_2014_nLBD_3P Qrob_Chr03 3 s_1ET7H8_604 s_1BYNB5_834 23,73 0 46,72 lod 1,7573 3,8
PM_1999_QTL14_peak_Bud_burst_3P Qrob_Chr03 3 s_2F0SI1_756 v_6056_735 11,78 3,78 50,78 lod 2,5 4,5
Bourran2_2014_nFork*_3P Qrob_Chr06 6 v_12930_125 s_1AMZEI_909 34,28 7,43 41,48 lod 2,4044 5,5
Bourran2_2014_rEpiBC*_3P Qrob_Chr03 3 s_1A3B3X_1163 s_1DKGMO_450 23,04 4,92 41,12 lod 2,5668 7

0 Targeting