GO Term : GO:0006099 tricarboxylic acid cycle GO

Namespace  biological_process Obsolete  false
description  A nearly universal metabolic pathway in which the acetyl group of acetyl coenzyme A is effectively oxidized to two CO2 and four pairs of electrons are transferred to coenzymes. The acetyl group combines with oxaloacetate to form citrate, which undergoes successive transformations to isocitrate, 2-oxoglutarate, succinyl-CoA, succinate, fumarate, malate, and oxaloacetate again, thus completing the cycle. In eukaryotes the tricarboxylic acid is confined to the mitochondria. See also glyoxylate cycle.

0 Cross References

1 Ontology

Name
GO

21 Parents

Identifier Name Description
GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation.
GO:0055114 oxidation-reduction process A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons.
GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances.
GO:0006099 tricarboxylic acid cycle A nearly universal metabolic pathway in which the acetyl group of acetyl coenzyme A is effectively oxidized to two CO2 and four pairs of electrons are transferred to coenzymes. The acetyl group combines with oxaloacetate to form citrate, which undergoes successive transformations to isocitrate, 2-oxoglutarate, succinyl-CoA, succinate, fumarate, malate, and oxaloacetate again, thus completing the cycle. In eukaryotes the tricarboxylic acid is confined to the mitochondria. See also glyoxylate cycle.
GO:0019752 carboxylic acid metabolic process The chemical reactions and pathways involving carboxylic acids, any organic acid containing one or more carboxyl (COOH) groups or anions (COO-).
GO:0071704 organic substance metabolic process The chemical reactions and pathways involving an organic substance, any molecular entity containing carbon.
GO:0009060 aerobic respiration The enzymatic release of energy from inorganic and organic compounds (especially carbohydrates and fats) which requires oxygen as the terminal electron acceptor.
GO:0044238 primary metabolic process The chemical reactions and pathways involving those compounds which are formed as a part of the normal anabolic and catabolic processes. These processes take place in most, if not all, cells of the organism.
GO:0044699 single-organism process A biological process that involves only one organism.
GO:0009987 cellular process Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.
GO:0008150 biological_process Any process specifically pertinent to the functioning of integrated living units: cells, tissues, organs, and organisms. A process is a collection of molecular events with a defined beginning and end.
GO:0044763 single-organism cellular process Any process that is carried out at the cellular level, occurring within a single organism.
GO:0044710 single-organism metabolic process A metabolic process - chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances - which involves a single organism.
GO:0006082 organic acid metabolic process The chemical reactions and pathways involving organic acids, any acidic compound containing carbon in covalent linkage.
GO:0043436 oxoacid metabolic process The chemical reactions and pathways involving any oxoacid; an oxoacid is a compound which contains oxygen, at least one other element, and at least one hydrogen bound to oxygen, and which produces a conjugate base by loss of positive hydrogen ion(s) (hydrons).
GO:0044281 small molecule metabolic process The chemical reactions and pathways involving small molecules, any low molecular weight, monomeric, non-encoded molecule.
GO:0072350 tricarboxylic acid metabolic process The chemical reactions and pathways involving dicarboxylic acids, any organic acid containing three carboxyl (COOH) groups or anions (COO-).
GO:0006091 generation of precursor metabolites and energy The chemical reactions and pathways resulting in the formation of precursor metabolites, substances from which energy is derived, and any process involved in the liberation of energy from these substances.
GO:0015980 energy derivation by oxidation of organic compounds The chemical reactions and pathways by which a cell derives energy from organic compounds; results in the oxidation of the compounds from which energy is released.
GO:0006101 citrate metabolic process The chemical reactions and pathways involving citrate, 2-hydroxy-1,2,3-propanetricarboyxlate. Citrate is widely distributed in nature and is an important intermediate in the TCA cycle and the glyoxylate cycle.
GO:0045333 cellular respiration The enzymatic release of energy from inorganic and organic compounds (especially carbohydrates and fats) which either requires oxygen (aerobic respiration) or does not (anaerobic respiration).

11 Protein

Protein Identifier
Organism . Name
Score Score Type Protein Description Alias (in v1) Code Enzyme Gene Prediction Quality
Qrob_P0042480.2 Quercus robur 90.0 egn (M=1) PTHR11739:SF8 - CITRATE SYNTHASE, MITOCHONDRIAL (PTHR11739:SF8)   EC:2.3.3.16 validated
Qrob_P0044150.2 Quercus robur 100.0 egn (M=3) 2.3.3.16 - Citrate synthase (unknown stereospecificity).   EC:2.3.3.16 validated
Qrob_P0053050.2 Quercus robur 87.1 egn (M=2) 2.3.1.61 - Dihydrolipoyllysine-residue succinyltransferase.   EC:2.3.1.61 validated
Qrob_P0120440.2 Quercus robur 95.0 egn (M=3) 1.2.4.2 - Oxoglutarate dehydrogenase (succinyl-transferring).   EC:1.2.4.2 validated
Qrob_P0120450.2 Quercus robur 100.0 egn (M=3) 1.2.4.2 - Oxoglutarate dehydrogenase (succinyl-transferring).   EC:1.2.4.2 validated
Qrob_P0121270.2 Quercus robur 100.0 egn (M=1) PTHR11921:SF8 - FUMARATE REDUCTASE IRON-SULFUR PROTEIN-RELATED   EC:1.3.5.1 validated
Qrob_P0335530.2 Quercus robur 100.0 egn (M=3) 2.3.3.16 - Citrate synthase (unknown stereospecificity).   EC:2.3.3.16 validated
Qrob_P0596800.2 Quercus robur 0.0 egn (M=1) PTHR11921:SF23 - SUCCINATE DEHYDROGENASE IRON-SULFUR PROTEIN   EC:1.3.5.1 validated
Qrob_P0608690.2 Quercus robur 100.0 egn (M=2) 4.1.1.31 - Phosphoenolpyruvate carboxylase.   EC:4.1.1.31 validated
Qrob_P0742900.2 Quercus robur     (M=2) 4.1.1.31 - Phosphoenolpyruvate carboxylase. Qrob_P0141980.1 EC:4.1.1.31 manual_v1
Qrob_P0752810.2 Quercus robur 71.2 egn (M=3) 1.2.4.2 - Oxoglutarate dehydrogenase (succinyl-transferring).   EC:1.2.4.2 validated

28 Relations

Relationship
Parent Term . Identifier

Child Term . Identifier
part of GO:0009060 GO:0006099
is_a GO:0006101 GO:0006099
is_a GO:0044238 GO:0006099
is_a GO:0008150 GO:0006099
is_a GO:0009987 GO:0006099
is_a GO:0044699 GO:0006099
is_a GO:0044710 GO:0006099
part of GO:0044237 GO:0006099
is_a GO:0072350 GO:0006099
is_a GO:0044237 GO:0006099
is_a GO:0008152 GO:0006099
is_a GO:0071704 GO:0006099
part of GO:0015980 GO:0006099
part of GO:0008152 GO:0006099
part of GO:0045333 GO:0006099
part of GO:0006091 GO:0006099
part of GO:0044699 GO:0006099
part of GO:0008150 GO:0006099
part of GO:0044710 GO:0006099
is_a GO:0006082 GO:0006099
is_a GO:0019752 GO:0006099
is_a GO:0044763 GO:0006099
is_a GO:0043436 GO:0006099
part of GO:0009987 GO:0006099
part of GO:0044763 GO:0006099
part of GO:0055114 GO:0006099
is_a GO:0044281 GO:0006099
is_a GO:0006099 GO:0019643

3 Synonyms

Name Type
Krebs cycle synonym
citric acid cycle synonym
TCA cycle synonym