GO Term : GO:0030976 thiamine pyrophosphate binding GO

Namespace  molecular_function Obsolete  false
description  Interacting selectively and non-covalently with thiamine pyrophosphate, the diphosphoric ester of thiamine. Acts as a coenzyme of several (de)carboxylases, transketolases, and alpha-oxoacid dehydrogenases.

0 Cross References

1 Ontology

Name
GO

13 Parents

Identifier Name Description
GO:0005488 binding The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule.
GO:0030976 thiamine pyrophosphate binding Interacting selectively and non-covalently with thiamine pyrophosphate, the diphosphoric ester of thiamine. Acts as a coenzyme of several (de)carboxylases, transketolases, and alpha-oxoacid dehydrogenases.
GO:0050662 coenzyme binding Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed.
GO:0043169 cation binding Interacting selectively and non-covalently with cations, charged atoms or groups of atoms with a net positive charge.
GO:0048037 cofactor binding Interacting selectively and non-covalently with a cofactor, a substance that is required for the activity of an enzyme or other protein. Cofactors may be inorganic, such as the metal atoms zinc, iron, and copper in certain forms, or organic, in which case they are referred to as coenzymes. Cofactors may either be bound tightly to active sites or bind loosely with the substrate.
GO:0003674 molecular_function Elemental activities, such as catalysis or binding, describing the actions of a gene product at the molecular level. A given gene product may exhibit one or more molecular functions.
GO:1901363 heterocyclic compound binding Interacting selectively and non-covalently with heterocyclic compound.
GO:0097159 organic cyclic compound binding Interacting selectively and non-covalently with an organic cyclic compound, any molecular entity that contains carbon arranged in a cyclic molecular structure.
GO:0043168 anion binding Interacting selectively and non-covalently with anions, charged atoms or groups of atoms with a net negative charge.
GO:1901681 sulfur compound binding Interacting selectively and non-covalently with a sulfur compound.
GO:0043167 ion binding Interacting selectively and non-covalently with ions, charged atoms or groups of atoms.
GO:0036094 small molecule binding Interacting selectively and non-covalently with a small molecule, any low molecular weight, monomeric, non-encoded molecule.
GO:0019842 vitamin binding Interacting selectively and non-covalently with a vitamin, one of a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body.

11 Protein

Protein Identifier
Organism . Name
Score Score Type Protein Description Alias (in v1) Code Enzyme Gene Prediction Quality
Qrob_P0029220.2 Quercus robur 100.0 egn (M=5) 4.1.1.1 - Pyruvate decarboxylase.   EC:4.1.1.1 validated
Qrob_P0086520.2 Quercus robur 100.0 egn (M=5) 4.1.1.1 - Pyruvate decarboxylase.   EC:4.1.1.1 validated
Qrob_P0120440.2 Quercus robur 95.0 egn (M=3) 1.2.4.2 - Oxoglutarate dehydrogenase (succinyl-transferring).   EC:1.2.4.2 validated
Qrob_P0120450.2 Quercus robur 100.0 egn (M=3) 1.2.4.2 - Oxoglutarate dehydrogenase (succinyl-transferring).   EC:1.2.4.2 validated
Qrob_P0398530.2 Quercus robur 100.0 egn (M=1) 4.1.1.8 - Oxalyl-CoA decarboxylase.   EC:4.1.1.8 validated
Qrob_P0682610.2 Quercus robur 0.0 egn (M=1) KOG1184//KOG1185 - Thiamine pyrophosphate-requiring enzyme [Amino acid transport and metabolism Coenzyme transport and metabolism]. // Thiamine pyrophosphate-requiring enzyme [Amino acid transport and metabolism Coenzyme transport and metabolism].   EC:4.1.1.1 validated
Qrob_P0682620.2 Quercus robur 0.0 egn (M=5) 4.1.1.1 - Pyruvate decarboxylase.   EC:4.1.1.1 validated
Qrob_P0682650.2 Quercus robur 0.0 egn (M=5) 4.1.1.1 - Pyruvate decarboxylase.   EC:4.1.1.1 validated
Qrob_P0685030.2 Quercus robur 0.0 egn (M=1) KOG1185//KOG1223//KOG4166 - Thiamine pyrophosphate-requiring enzyme [Amino acid transport and metabolism Coenzyme transport and metabolism]. // Isochorismate synthase [Amino acid transport and metabolism]. // Thiamine pyrophosphate-requiring enzyme [Amino acid transport and metabolism Coenzyme transport and metabolism].   EC:2.2.1.9, EC:4.2.99.20, EC:4.2.1.113 validated
Qrob_P0685050.2 Quercus robur 84.2 egn (M=1) K14759 - isochorismate synthase / 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase / 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase / O-succinylbenzoate synthase [EC:5.4.4.2 2.2.1.9 4.2.99.20 4.2.1.113]   EC:2.2.1.9, EC:4.2.99.20, EC:4.2.1.113 validated
Qrob_P0752810.2 Quercus robur 71.2 egn (M=3) 1.2.4.2 - Oxoglutarate dehydrogenase (succinyl-transferring).   EC:1.2.4.2 validated

12 Relations

Relationship
Parent Term . Identifier

Child Term . Identifier
is_a GO:0043168 GO:0030976
is_a GO:0097159 GO:0030976
is_a GO:1901681 GO:0030976
is_a GO:0019842 GO:0030976
is_a GO:0050662 GO:0030976
is_a GO:1901363 GO:0030976
is_a GO:0043169 GO:0030976
is_a GO:0005488 GO:0030976
is_a GO:0048037 GO:0030976
is_a GO:0036094 GO:0030976
is_a GO:0003674 GO:0030976
is_a GO:0043167 GO:0030976

5 Synonyms

Name Type
TPP binding synonym
thiamin pyrophosphate binding synonym
diphosphothiamin binding synonym
cocarboxylase binding synonym
aneurine pyrophosphate binding synonym