GO Term : GO:0008278 cohesin complex GO

Namespace  cellular_component Obsolete  false
description  A protein complex that is required for sister chromatid cohesion in eukaryotes. The cohesin complex forms a molecular ring complex, and is composed of structural maintenance of chromosomes (SMC) and kleisin proteins. For example, in yeast, the complex is composed of the SMC proteins Smc1p and Smc3p, and the kleisin protein Scc1p. In vertebrates, the complex is composed of the SMC1 (SMC1A or SMC1B) and SMC3 heterodimer attached via their hinge domains to a kleisin (RAD21, REC8 or RAD21L) which links them, and one STAG protein (STAG1, STAG2 or STAG3).

0 Cross References

1 Ontology

Name
GO

17 Parents

Identifier Name Description
GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm.
GO:0005694 chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information.
GO:0043234 protein complex A stable macromolecular complex composed (only) of two or more polypeptide subunits along with any covalently attached molecules (such as lipid anchors or oligosaccharide) or non-protein prosthetic groups (such as nucleotides or metal ions). Prosthetic group in this context refers to a tightly bound cofactor. The component polypeptide subunits may be identical.
GO:0008278 cohesin complex A protein complex that is required for sister chromatid cohesion in eukaryotes. The cohesin complex forms a molecular ring complex, and is composed of structural maintenance of chromosomes (SMC) and kleisin proteins. For example, in yeast, the complex is composed of the SMC proteins Smc1p and Smc3p, and the kleisin protein Scc1p. In vertebrates, the complex is composed of the SMC1 (SMC1A or SMC1B) and SMC3 heterodimer attached via their hinge domains to a kleisin (RAD21, REC8 or RAD21L) which links them, and one STAG protein (STAG1, STAG2 or STAG3).
GO:0044424 intracellular part Any constituent part of the living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm.
GO:0005623 cell The basic structural and functional unit of all organisms. Includes the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope.
GO:0032991 macromolecular complex A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which the constituent parts function together.
GO:0044464 cell part Any constituent part of a cell, the basic structural and functional unit of all organisms.
GO:0005575 cellular_component The part of a cell or its extracellular environment in which a gene product is located. A gene product may be located in one or more parts of a cell and its location may be as specific as a particular macromolecular complex, that is, a stable, persistent association of macromolecules that function together.
GO:0044422 organelle part Any constituent part of an organelle, an organized structure of distinctive morphology and function. Includes constituent parts of the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton, but excludes the plasma membrane.
GO:0044446 intracellular organelle part A constituent part of an intracellular organelle, an organized structure of distinctive morphology and function, occurring within the cell. Includes constituent parts of the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton but excludes the plasma membrane.
GO:0043226 organelle Organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton, and prokaryotic structures such as anammoxosomes and pirellulosomes. Excludes the plasma membrane.
GO:0043229 intracellular organelle Organized structure of distinctive morphology and function, occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane.
GO:0043228 non-membrane-bounded organelle Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane. Includes ribosomes, the cytoskeleton and chromosomes.
GO:0043232 intracellular non-membrane-bounded organelle Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane and occurring within the cell. Includes ribosomes, the cytoskeleton and chromosomes.
GO:0044427 chromosomal part Any constituent part of a chromosome, a structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information.
GO:0000793 condensed chromosome A highly compacted molecule of DNA and associated proteins resulting in a cytologically distinct structure.

4 Protein

Protein Identifier
Organism . Name
Score Score Type Protein Description Alias (in v1) Code Enzyme Gene Prediction Quality
Qrob_P0369300.2 Quercus robur 0.0 egn (M=1) KOG0018//KOG0933//KOG0964//KOG0979//KOG0996 - Structural maintenance of chromosome protein 1 (sister chromatid cohesion complex Cohesin subunit SMC1) [Cell cycle control cell division chromosome partitioning]. // Structural maintenance of chromosome protein 2 (chromosome condensation complex Condensin subunit E) [Chromatin structure and dynamics Cell cycle control cell division chromosome partitioning]. // Structural maintenance of chromosome protein 3 (sister chromatid cohesion complex Cohesin subunit SMC3) [Cell cycle control cell division chromosome partitioning]. // Structural maintenance of chromosome protein SMC5/Spr18 SMC superfamily [Chromatin structure and dynamics Cell cycle control cell division chromosome partitioning Replication recombination and repair]. // Structural maintenance of chromosome protein 4 (chromosome condensation complex Condensin subunit C) [Chromatin structure and dynamics Cell cycle control cell division chromosome partitioning].     validated
Qrob_P0369410.2 Quercus robur 46.4 egn (M=1) KOG0018//KOG0161//KOG0239//KOG0250//KOG0933//KOG0964//KOG0979//KOG0996 - Structural maintenance of chromosome protein 1 (sister chromatid cohesion complex Cohesin subunit SMC1) [Cell cycle control cell division chromosome partitioning]. // Myosin class II heavy chain [Cytoskeleton]. // Kinesin (KAR3 subfamily) [Cytoskeleton]. // DNA repair protein RAD18 (SMC family protein) [Replication recombination and repair]. // Structural maintenance of chromosome protein 2 (chromosome condensation complex Condensin subunit E) [Chromatin structure and dynamics Cell cycle control cell division chromosome partitioning]. // Structural maintenance of chromosome protein 3 (sister chromatid cohesion complex Cohesin subunit SMC3) [Cell cycle control cell division chromosome partitioning]. // Structural maintenance of chromosome protein SMC5/Spr18 SMC superfamily [Chromatin structure and dynamics Cell cycle control cell division chromosome partitioning Replication recombination and repair]. // Structural maintenance of chromosome protein 4 (chromosome condensation complex Condensin subunit C) [Chromatin structure and dynamics Cell cycle control cell division chromosome partitioning].     validated
Qrob_P0369420.2 Quercus robur 0.0 egn (M=1) KOG0018//KOG0933//KOG0964//KOG0996 - Structural maintenance of chromosome protein 1 (sister chromatid cohesion complex Cohesin subunit SMC1) [Cell cycle control cell division chromosome partitioning]. // Structural maintenance of chromosome protein 2 (chromosome condensation complex Condensin subunit E) [Chromatin structure and dynamics Cell cycle control cell division chromosome partitioning]. // Structural maintenance of chromosome protein 3 (sister chromatid cohesion complex Cohesin subunit SMC3) [Cell cycle control cell division chromosome partitioning]. // Structural maintenance of chromosome protein 4 (chromosome condensation complex Condensin subunit C) [Chromatin structure and dynamics Cell cycle control cell division chromosome partitioning].     validated
Qrob_P0369440.2 Quercus robur 15.7 egn (M=5) K06636 - structural maintenance of chromosome 1     validated

25 Relations

Relationship
Parent Term . Identifier

Child Term . Identifier
is_a GO:0008278 GO:0000798
is_a GO:0044427 GO:0008278
part of GO:0000793 GO:0008278
is_a GO:0043234 GO:0008278
is_a GO:0044464 GO:0008278
is_a GO:0044446 GO:0008278
part of GO:0005694 GO:0008278
is_a GO:0032991 GO:0008278
is_a GO:0044422 GO:0008278
part of GO:0043232 GO:0008278
is_a GO:0044424 GO:0008278
part of GO:0044464 GO:0008278
part of GO:0043229 GO:0008278
part of GO:0005575 GO:0008278
part of GO:0044424 GO:0008278
part of GO:0043228 GO:0008278
part of GO:0043226 GO:0008278
part of GO:0005623 GO:0008278
is_a GO:0005575 GO:0008278
part of GO:0005622 GO:0008278
part of GO:0008278 GO:0008280
is_a GO:0008278 GO:0030892
is_a GO:0008278 GO:0030893
is_a GO:0008278 GO:0034990
is_a GO:0008278 GO:0034991

5 Synonyms

Name Type
SMC complex synonym
GO:0008279 alt_id
GO:0043222 alt_id
14S cohesin synonym
SMC/kleisin ring complex synonym