GO Term : GO:0008534 oxidized purine nucleobase lesion DNA N-glycosylase activity GO
Namespace  molecular_function Obsolete  false
description  Catalysis of the removal of oxidized purine bases by cleaving the N-C1' glycosidic bond between the oxidized purine and the deoxyribose sugar. The reaction involves the formation of a covalent enzyme-substrate intermediate. Release of the enzyme and free base by a beta-elimination or a beta, gamma-elimination mechanism results in the cleavage of the DNA backbone 3' of the apurinic (AP) site.
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0 Cross References

1 Ontology

Name
GO

16 Parents

Identifier Name Description
GO:0003824 catalytic activity Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic.
GO:0016798 hydrolase activity, acting on glycosyl bonds Catalysis of the hydrolysis of any glycosyl bond.
GO:0016787 hydrolase activity Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3.
GO:0004518 nuclease activity Catalysis of the hydrolysis of ester linkages within nucleic acids.
GO:0016788 hydrolase activity, acting on ester bonds Catalysis of the hydrolysis of any ester bond.
GO:0004519 endonuclease activity Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks.
GO:0016829 lyase activity Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring.
GO:0016799 hydrolase activity, hydrolyzing N-glycosyl compounds Catalysis of the hydrolysis of any N-glycosyl bond.
GO:0008534 oxidized purine nucleobase lesion DNA N-glycosylase activity Catalysis of the removal of oxidized purine bases by cleaving the N-C1' glycosidic bond between the oxidized purine and the deoxyribose sugar. The reaction involves the formation of a covalent enzyme-substrate intermediate. Release of the enzyme and free base by a beta-elimination or a beta, gamma-elimination mechanism results in the cleavage of the DNA backbone 3' of the apurinic (AP) site.
GO:0003906 DNA-(apurinic or apyrimidinic site) lyase activity Catalysis of the cleavage of the C-O-P bond 3' to the apurinic or apyrimidinic site in DNA by a beta-elimination reaction, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.
GO:0003674 molecular_function Elemental activities, such as catalysis or binding, describing the actions of a gene product at the molecular level. A given gene product may exhibit one or more molecular functions.
GO:0004520 endodeoxyribonuclease activity Catalysis of the hydrolysis of ester linkages within deoxyribonucleic acid by creating internal breaks.
GO:0004536 deoxyribonuclease activity Catalysis of the hydrolysis of ester linkages within deoxyribonucleic acid.
GO:0019104 DNA N-glycosylase activity Catalysis of the removal of damaged bases by cleaving the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar. The reaction releases a free base and leaves an apurinic/apyrimidinic (AP) site.
GO:0000702 oxidized base lesion DNA N-glycosylase activity Catalysis of the removal of oxidized bases by cleaving the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar. The reaction releases a free base and leaves an apurinic/apyrimidinic (AP) site.
GO:0016835 carbon-oxygen lyase activity Catalysis of the breakage of a carbon-oxygen bond.

2 Protein

Protein Identifier
Organism . Name 		Score Score Type Protein Description Alias (in v1) Code Enzyme Gene Prediction Quality
Qrob_P0186130.2 Quercus robur 100.0 egn (M=1) K03660 - N-glycosylase/DNA lyase [EC:3.2.2.- 4.2.99.18]   EC:4.2.99.18 validated
Qrob_P0221470.2 Quercus robur 100.0 egn (M=1) 3.2.2.23 - DNA-formamidopyrimidine glycosylase.   EC:4.2.99.18, EC:3.2.2.23 validated

16 Relations

Relationship
Parent Term . Identifier
Child Term . Identifier
is_a GO:0000702 GO:0008534
is_a GO:0003906 GO:0008534
is_a GO:0003674 GO:0008534
is_a GO:0004519 GO:0008534
is_a GO:0004518 GO:0008534
is_a GO:0016835 GO:0008534
is_a GO:0019104 GO:0008534
is_a GO:0003824 GO:0008534
is_a GO:0016788 GO:0008534
is_a GO:0004536 GO:0008534
is_a GO:0016799 GO:0008534
is_a GO:0016798 GO:0008534
is_a GO:0016829 GO:0008534
is_a GO:0016787 GO:0008534
is_a GO:0004520 GO:0008534
is_a GO:0008534 GO:0034039

15 Synonyms

Name Type
deoxyribonucleate glycosidase activity synonym
DNA glycohydrolase [2,6-diamino-4-hydroxy-5-(N-methyl)formamidopyrimide releasing] synonym
DNA glycosylase/AP-lyase activity synonym
DNA glycosylase/beta-lyase activity synonym
2,6-diamino-4-hydroxy-5(N-methyl)formamidopyrimidine-DNA glycosylase activity synonym
2,6-diamino-4-hydroxy-5N-formamidopyrimidine-DNA glycosylase activity synonym
8-oxoguanine DNA glycosylase activity synonym
bifunctional DNA glycosylase activity synonym
formamidopyrimidine-DNA glycosylase activity synonym
Fpg protein synonym
DNA-formamidopyrimidine glycosylase activity synonym
Fapy-DNA glycosylase activity synonym
GO:0003907 alt_id
oxidized purine base lesion DNA N-glycosylase activity synonym
purine-specific oxidized base lesion DNA N-glycosylase activity synonym