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GO:0008270
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zinc ion binding
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Interacting selectively and non-covalently with zinc (Zn) ions. |
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GO:0003676
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nucleic acid binding
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Interacting selectively and non-covalently with any nucleic acid. |
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GO:0006289
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nucleotide-excision repair
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A DNA repair process in which a small region of the strand surrounding the damage is removed from the DNA helix as an oligonucleotide. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. Nucleotide excision repair recognizes a wide range of substrates, including damage caused by UV irradiation (pyrimidine dimers and 6-4 photoproducts) and chemicals (intrastrand cross-links and bulky adducts). |
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GO:0003684
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damaged DNA binding
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Interacting selectively and non-covalently with damaged DNA. |
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GO:0006281
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DNA repair
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The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. |
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GO:0006284
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base-excision repair
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In base excision repair, an altered base is removed by a DNA glycosylase enzyme, followed by excision of the resulting sugar phosphate. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. |
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GO:0016799
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hydrolase activity, hydrolyzing N-glycosyl compounds
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Catalysis of the hydrolysis of any N-glycosyl bond. |
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GO:0008534
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oxidized purine nucleobase lesion DNA N-glycosylase activity
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Catalysis of the removal of oxidized purine bases by cleaving the N-C1' glycosidic bond between the oxidized purine and the deoxyribose sugar. The reaction involves the formation of a covalent enzyme-substrate intermediate. Release of the enzyme and free base by a beta-elimination or a beta, gamma-elimination mechanism results in the cleavage of the DNA backbone 3' of the apurinic (AP) site. |
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GO:0003906
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DNA-(apurinic or apyrimidinic site) lyase activity
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Catalysis of the cleavage of the C-O-P bond 3' to the apurinic or apyrimidinic site in DNA by a beta-elimination reaction, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate. |
