GO Term : GO:0018024 histone-lysine N-methyltransferase activity GO

Namespace  molecular_function Obsolete  false
description  Catalysis of the reaction: S-adenosyl-L-methionine + histone L-lysine = S-adenosyl-L-homocysteine + histone N6-methyl-L-lysine. The methylation of peptidyl-lysine in histones forms N6-methyl-L-lysine, N6,N6-dimethyl-L-lysine and N6,N6,N6-trimethyl-L-lysine derivatives.

0 Cross References

1 Ontology

Name
GO

12 Parents

Identifier Name Description
GO:0003824 catalytic activity Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic.
GO:0008168 methyltransferase activity Catalysis of the transfer of a methyl group to an acceptor molecule.
GO:0016740 transferase activity Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2.
GO:0008757 S-adenosylmethionine-dependent methyltransferase activity Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to a substrate.
GO:0018024 histone-lysine N-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + histone L-lysine = S-adenosyl-L-homocysteine + histone N6-methyl-L-lysine. The methylation of peptidyl-lysine in histones forms N6-methyl-L-lysine, N6,N6-dimethyl-L-lysine and N6,N6,N6-trimethyl-L-lysine derivatives.
GO:0008276 protein methyltransferase activity Catalysis of the transfer of a methyl group (CH3-) to a protein.
GO:0003674 molecular_function Elemental activities, such as catalysis or binding, describing the actions of a gene product at the molecular level. A given gene product may exhibit one or more molecular functions.
GO:0008170 N-methyltransferase activity Catalysis of the transfer of a methyl group to the nitrogen atom of an acceptor molecule.
GO:0016741 transferase activity, transferring one-carbon groups Catalysis of the transfer of a one-carbon group from one compound (donor) to another (acceptor).
GO:0016279 protein-lysine N-methyltransferase activity Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to the epsilon-amino group of a lysine residue in a protein substrate.
GO:0016278 lysine N-methyltransferase activity Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to the epsilon-amino group of a lysine residue.
GO:0042054 histone methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + histone = S-adenosyl-L-homocysteine + methyl-histone. Histone methylation generally occurs on either an arginine or lysine residue.

13 Protein

Protein Identifier
Organism . Name
Score Score Type Protein Description Alias (in v1) Code Enzyme Gene Prediction Quality
Qrob_P0032560.2 Quercus robur 99.1 egn (M=2) K11423 - histone-lysine N-methyltransferase SETD2 [EC:2.1.1.43]   EC:2.1.1.43 validated
Qrob_P0071080.2 Quercus robur 0.0 egn (M=1) K11433 - histone-lysine N-methyltransferase SETMAR [EC:2.1.1.43]   EC:2.1.1.43 validated
Qrob_P0107040.2 Quercus robur 0.0 egn (M=1) KOG1082//KOG1141 - Histone H3 (Lys9) methyltransferase SUV39H1/Clr4 required for transcriptional silencing [Chromatin structure and dynamics Transcription]. // Predicted histone methyl transferase [Chromatin structure and dynamics].   EC:2.1.1.43 validated
Qrob_P0114130.2 Quercus robur 0.0 egn (M=1) KOG1082//KOG1083//KOG1141//KOG4442 - Histone H3 (Lys9) methyltransferase SUV39H1/Clr4 required for transcriptional silencing [Chromatin structure and dynamics Transcription]. // Putative transcription factor ASH1/LIN-59 [Transcription]. // Predicted histone methyl transferase [Chromatin structure and dynamics]. // Clathrin coat binding protein/Huntingtin interacting protein HIP1 involved in regulation of endocytosis [Intracellular trafficking secretion and vesicular transport].   EC:2.1.1.43 validated
Qrob_P0114140.2 Quercus robur 0.0 egn (M=2) KOG1079//KOG1080//KOG1082//KOG1083//KOG1085//KOG1141//KOG4442 - Transcriptional repressor EZH1 [Transcription]. // Histone H3 (Lys4) methyltransferase complex subunit SET1 and related methyltransferases [Chromatin structure and dynamics Transcription]. // Histone H3 (Lys9) methyltransferase SUV39H1/Clr4 required for transcriptional silencing [Chromatin structure and dynamics Transcription]. // Putative transcription factor ASH1/LIN-59 [Transcription]. // Predicted methyltransferase (contains a SET domain) [General function prediction only]. // Predicted histone methyl transferase [Chromatin structure and dynamics]. // Clathrin coat binding protein/Huntingtin interacting protein HIP1 involved in regulation of endocytosis [Intracellular trafficking secretion and vesicular transport].   EC:2.1.1.43 validated
Qrob_P0135830.2 Quercus robur 100.0 egn (M=3) PTHR22884:SF23 - SET DOMAIN PROTEIN   EC:2.1.1.43 validated
Qrob_P0354480.2 Quercus robur 61.0 egn (M=1) KOG1080//KOG1082//KOG1083//KOG1141//KOG4442 - Histone H3 (Lys4) methyltransferase complex subunit SET1 and related methyltransferases [Chromatin structure and dynamics Transcription]. // Histone H3 (Lys9) methyltransferase SUV39H1/Clr4 required for transcriptional silencing [Chromatin structure and dynamics Transcription]. // Putative transcription factor ASH1/LIN-59 [Transcription]. // Predicted histone methyl transferase [Chromatin structure and dynamics]. // Clathrin coat binding protein/Huntingtin interacting protein HIP1 involved in regulation of endocytosis [Intracellular trafficking secretion and vesicular transport].   EC:2.1.1.43 validated
Qrob_P0361590.2 Quercus robur 73.5 egn (M=3) PTHR22884:SF23 - SET DOMAIN PROTEIN   EC:2.1.1.43 validated
Qrob_P0551120.2 Quercus robur 96.0 egn (M=1) KOG1080//KOG1082//KOG1141//KOG4442 - Histone H3 (Lys4) methyltransferase complex subunit SET1 and related methyltransferases [Chromatin structure and dynamics Transcription]. // Histone H3 (Lys9) methyltransferase SUV39H1/Clr4 required for transcriptional silencing [Chromatin structure and dynamics Transcription]. // Predicted histone methyl transferase [Chromatin structure and dynamics]. // Clathrin coat binding protein/Huntingtin interacting protein HIP1 involved in regulation of endocytosis [Intracellular trafficking secretion and vesicular transport].   EC:2.1.1.43 validated
Qrob_P0665480.2 Quercus robur 0.0 egn (M=8) K11420 - euchromatic histone-lysine N-methyltransferase [EC:2.1.1.43]   EC:2.1.1.43 validated
Qrob_P0666140.2 Quercus robur 100.0 egn (M=1) PTHR22884:SF95 - SET DOMAIN CONTAINING PROTEIN   EC:2.1.1.43 validated
Qrob_P0678250.2 Quercus robur 0.0 egn (M=1) KOG1082//KOG1141//KOG4442 - Histone H3 (Lys9) methyltransferase SUV39H1/Clr4 required for transcriptional silencing [Chromatin structure and dynamics Transcription]. // Predicted histone methyl transferase [Chromatin structure and dynamics]. // Clathrin coat binding protein/Huntingtin interacting protein HIP1 involved in regulation of endocytosis [Intracellular trafficking secretion and vesicular transport].   EC:2.1.1.43 validated
Qrob_P0732900.2 Quercus robur 100.0 egn (M=1) PTHR22884:SF300 - HISTONE-LYSINE N-METHYLTRANSFERASE, H3 LYSINE-9 SPECIFIC SUVH10-RELATED (PTHR22884:SF300)   EC:2.1.1.43 validated

17 Relations

Relationship
Parent Term . Identifier

Child Term . Identifier
is_a GO:0042054 GO:0018024
is_a GO:0016279 GO:0018024
is_a GO:0003674 GO:0018024
is_a GO:0008757 GO:0018024
is_a GO:0008170 GO:0018024
is_a GO:0016740 GO:0018024
is_a GO:0003824 GO:0018024
is_a GO:0016741 GO:0018024
is_a GO:0008168 GO:0018024
is_a GO:0008276 GO:0018024
is_a GO:0016278 GO:0018024
is_a GO:0018024 GO:0031151
is_a GO:0018024 GO:0042799
is_a GO:0018024 GO:0042800
is_a GO:0018024 GO:0046974
is_a GO:0018024 GO:0046975
is_a GO:0018024 GO:0046976

8 Synonyms

Name Type
histone H1-specific S-adenosylmethionine:protein-lysine N-methyltransferase activity synonym
histone-lysine N-methylase activity synonym
protein methyltransferase II activity synonym
protein methylase III activity synonym
protein methylase 3 activity synonym
protein (lysine) methyltransferase activity synonym
S-adenosyl-L-methionine:histone-L-lysine N6-methyltransferase activity synonym
S-adenosyl-L-methionine:histone-L-lysine 6-N-methyltransferase activity synonym