GO Term : GO:0042800 histone methyltransferase activity (H3-K4 specific) GO

Namespace  molecular_function Obsolete  false
description  Catalysis of the reaction: S-adenosyl-L-methionine + histone H3 L-lysine (position 4) = S-adenosyl-L-homocysteine + histone H3 N6-methyl-L-lysine (position 4). This reaction is the addition of a methyl group onto lysine at position 4 of the histone H3 protein.

0 Cross References

1 Ontology

Name
GO

13 Parents

Identifier Name Description
GO:0003824 catalytic activity Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic.
GO:0008168 methyltransferase activity Catalysis of the transfer of a methyl group to an acceptor molecule.
GO:0016740 transferase activity Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2.
GO:0008757 S-adenosylmethionine-dependent methyltransferase activity Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to a substrate.
GO:0018024 histone-lysine N-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + histone L-lysine = S-adenosyl-L-homocysteine + histone N6-methyl-L-lysine. The methylation of peptidyl-lysine in histones forms N6-methyl-L-lysine, N6,N6-dimethyl-L-lysine and N6,N6,N6-trimethyl-L-lysine derivatives.
GO:0008276 protein methyltransferase activity Catalysis of the transfer of a methyl group (CH3-) to a protein.
GO:0003674 molecular_function Elemental activities, such as catalysis or binding, describing the actions of a gene product at the molecular level. A given gene product may exhibit one or more molecular functions.
GO:0008170 N-methyltransferase activity Catalysis of the transfer of a methyl group to the nitrogen atom of an acceptor molecule.
GO:0016741 transferase activity, transferring one-carbon groups Catalysis of the transfer of a one-carbon group from one compound (donor) to another (acceptor).
GO:0016279 protein-lysine N-methyltransferase activity Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to the epsilon-amino group of a lysine residue in a protein substrate.
GO:0016278 lysine N-methyltransferase activity Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to the epsilon-amino group of a lysine residue.
GO:0042054 histone methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + histone = S-adenosyl-L-homocysteine + methyl-histone. Histone methylation generally occurs on either an arginine or lysine residue.
GO:0042800 histone methyltransferase activity (H3-K4 specific) Catalysis of the reaction: S-adenosyl-L-methionine + histone H3 L-lysine (position 4) = S-adenosyl-L-homocysteine + histone H3 N6-methyl-L-lysine (position 4). This reaction is the addition of a methyl group onto lysine at position 4 of the histone H3 protein.

0 Protein

12 Relations

Relationship
Parent Term . Identifier

Child Term . Identifier
is_a GO:0018024 GO:0042800
is_a GO:0003824 GO:0042800
is_a GO:0016740 GO:0042800
is_a GO:0016741 GO:0042800
is_a GO:0008276 GO:0042800
is_a GO:0003674 GO:0042800
is_a GO:0016279 GO:0042800
is_a GO:0016278 GO:0042800
is_a GO:0008170 GO:0042800
is_a GO:0008168 GO:0042800
is_a GO:0008757 GO:0042800
is_a GO:0042054 GO:0042800

3 Synonyms

Name Type
histone H3 lysine 4-specific methyltransferase activity synonym
histone lysine N-methyltransferase activity (H3-K4 specific) synonym
histone methylase activity (H3-K4 specific) synonym