Protein : Qrob_P0458540.2 Q. robur
Protein Identifier  ? Qrob_P0458540.2 Organism . Name  Quercus robur
Score  0.0 Score Type  egn
Protein Description  (M=7) PTHR10110:SF101 - SODIUM/HYDROGEN EXCHANGER 4 (PTHR10110:SF101) Gene Prediction Quality  validated
Protein length 

Sequence

Length: 489  
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0 Synonyms

9 GO Terms

Identifier Name Description
GO:0055085 transmembrane transport The process in which a solute is transported from one side of a membrane to the other.
GO:0016021 integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
GO:0006814 sodium ion transport The directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
GO:0015299 solute:proton antiporter activity Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + H+(in) = solute(in) + H+(out).
GO:0005774 vacuolar membrane The lipid bilayer surrounding the vacuole and separating its contents from the cytoplasm of the cell.
GO:0005886 plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
GO:0009651 response to salt stress Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of salt (particularly but not exclusively sodium and chloride ions) in the environment.
GO:0055075 potassium ion homeostasis Any process involved in the maintenance of an internal steady state of potassium ions within an organism or cell.

28 Blast

Analysis Hit Start End Strand Length Note Hit Coverage Hit Length Hit Pident E Val Hit Description
blastp_kegg lcl|pmum:103326597 3 486 + 484 Gaps:35 98.48 525 72.34 0.0 sodium/hydrogen exchanger 4
blastp_kegg lcl|mdm:103448345 4 488 + 485 Gaps:35 99.04 523 72.39 0.0 sodium/hydrogen exchanger 4
blastp_kegg lcl|pxb:103954518 5 488 + 484 Gaps:35 98.85 523 72.53 0.0 sodium/hydrogen exchanger 4-like
blastp_kegg lcl|tcc:TCM_030756 1 484 + 484 Gaps:36 99.04 523 71.24 0.0 Na+/H+ (sodium hydrogen) exchanger 3
blastp_kegg lcl|pxb:103931599 5 488 + 484 Gaps:35 98.85 523 71.95 0.0 sodium/hydrogen exchanger 4-like
blastp_kegg lcl|mtr:MTR_3g055600 1 488 + 488 Gaps:62 98.03 557 69.60 0.0 Sodium/hydrogen exchanger
blastp_kegg lcl|cam:101506751 8 488 + 481 Gaps:66 97.84 555 69.98 0.0 sodium/hydrogen exchanger 4-like
blastp_kegg lcl|gmx:100813332 5 488 + 484 Gaps:39 98.11 529 73.41 0.0 sodium/hydrogen exchanger 4-like
blastp_kegg lcl|fve:101305148 3 488 + 486 Gaps:35 99.43 522 71.10 0.0 sodium/hydrogen exchanger 4-like
blastp_kegg lcl|rcu:RCOM_0046150 5 488 + 484 Gaps:37 99.04 520 69.71 0.0 sodium/hydrogen exchanger putative
blastp_uniprot_sprot sp|Q8S397|NHX4_ARATH 5 488 + 484 Gaps:39 98.87 529 65.97 0.0 Sodium/hydrogen exchanger 4 OS Arabidopsis thaliana GN NHX4 PE 2 SV 2
blastp_uniprot_sprot sp|Q56XP4|NHX2_ARATH 9 480 + 472 Gaps:46 93.77 546 56.05 0.0 Sodium/hydrogen exchanger 2 OS Arabidopsis thaliana GN NHX2 PE 2 SV 2
blastp_uniprot_sprot sp|Q68KI4|NHX1_ARATH 7 480 + 474 Gaps:40 94.42 538 56.10 0.0 Sodium/hydrogen exchanger 1 OS Arabidopsis thaliana GN NHX1 PE 1 SV 2
blastp_uniprot_sprot sp|Q84WG1|NHX3_ARATH 13 410 + 398 Gaps:36 85.49 503 60.23 2e-168 Sodium/hydrogen exchanger 3 OS Arabidopsis thaliana GN NHX3 PE 2 SV 2
blastp_uniprot_sprot sp|Q5ZJ75|SL9A8_CHICK 13 478 + 466 Gaps:92 85.02 574 33.40 5e-49 Sodium/hydrogen exchanger 8 OS Gallus gallus PE 2 SV 1
blastp_uniprot_sprot sp|Q552S0|NHE1_DICDI 10 486 + 477 Gaps:90 68.99 674 31.83 2e-47 Sodium/hydrogen exchanger 1 OS Dictyostelium discoideum GN nhe1 PE 2 SV 1
blastp_uniprot_sprot sp|Q9Y2E8|SL9A8_HUMAN 13 486 + 474 Gaps:92 85.37 581 32.86 2e-47 Sodium/hydrogen exchanger 8 OS Homo sapiens GN SLC9A8 PE 1 SV 4
blastp_uniprot_sprot sp|Q4L208|SL9A8_RAT 13 486 + 474 Gaps:98 86.26 575 33.27 3e-47 Sodium/hydrogen exchanger 8 OS Rattus norvegicus GN Slc9a8 PE 2 SV 1
blastp_uniprot_sprot sp|Q8R4D1|SL9A8_MOUSE 13 486 + 474 Gaps:98 86.11 576 33.06 5e-47 Sodium/hydrogen exchanger 8 OS Mus musculus GN Slc9a8 PE 2 SV 1
blastp_uniprot_sprot sp|Q04121|NHX1_YEAST 42 364 + 323 Gaps:58 57.35 633 30.85 9e-41 Endosomal/prevacuolar sodium/hydrogen exchanger OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN NHX1 PE 1 SV 1
rpsblast_cdd gnl|CDD|162063 19 475 + 457 Gaps:99 82.29 559 29.78 2e-43 TIGR00840 b_cpa1 sodium/hydrogen exchanger 3. The Monovalent Cation:Proton Antiporter-1 (CPA1) Family (TC 2.A.36)The CPA1 family is a large family of proteins derived from Gram-positive and Gram-negative bacteria blue green bacteria yeast plants and animals.Transporters from eukaryotes have been functionally characterized and all of these catalyze Na+:H+ exchange. Their primary physiological functions may be in(1) cytoplasmic pH regulation extruding the H+ generated during metabolism and (2) salt tolerance (in plants) due to Na+ uptake into vacuoles.This Hmm is specific for the eukaryotic members members of this family.
rpsblast_cdd gnl|CDD|201544 21 402 + 382 Gaps:74 100.00 370 27.03 7e-24 pfam00999 Na_H_Exchanger Sodium/hydrogen exchanger family. Na/H antiporters are key transporters in maintaining the pH of actively metabolising cells. The molecular mechanisms of antiport are unclear. These antiporters contain 10-12 transmembrane regions (M) at the amino-terminus and a large cytoplasmic region at the carboxyl terminus. The transmembrane regions M3-M12 share identity with other members of the family. The M6 and M7 regions are highly conserved. Thus this is thought to be the region that is involved in the transport of sodium and hydrogen ions. The cytoplasmic region has little similarity throughout the family.
rpsblast_cdd gnl|CDD|30375 18 408 + 391 Gaps:54 93.47 429 23.69 2e-22 COG0025 NhaP NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism].
rpsblast_cdd gnl|CDD|129911 48 398 + 351 Gaps:59 70.86 525 24.46 4e-16 TIGR00831 a_cpa1 Na+/H+ antiporter bacterial form. The Monovalent Cation:Proton Antiporter-1 (CPA1) Family (TC 2.A.36) The CPA1 family is a large family of proteins derived from Gram-positive and Gram-negative bacteria blue green bacteria yeast plants and animals. Transporters from eukaryotes have been functionally characterized and all of these catalyze Na+:H+ exchange. Their primary physiological functions may be in (1) cytoplasmic pH regulation extruding the H+ generated during metabolism and (2) salt tolerance (in plants) due to Na+ uptake into vacuoles. This Hmm is specific for the bacterial members of this family.
rpsblast_cdd gnl|CDD|180017 92 398 + 307 Gaps:70 48.58 562 28.57 1e-08 PRK05326 PRK05326 potassium/proton antiporter Reviewed.
rpsblast_cdd gnl|CDD|33074 92 408 + 317 Gaps:55 48.78 574 25.36 2e-08 COG3263 COG3263 NhaP-type Na+/H+ and K+/H+ antiporters with a unique C-terminal domain [Inorganic ion transport and metabolism].
rpsblast_kog gnl|CDD|37176 8 480 + 473 Gaps:74 91.30 575 40.19 1e-113 KOG1965 KOG1965 KOG1965 Sodium/hydrogen exchanger protein [Inorganic ion transport and metabolism].
rpsblast_kog gnl|CDD|37177 18 477 + 460 Gaps:96 68.96 670 27.92 4e-35 KOG1966 KOG1966 KOG1966 Sodium/hydrogen exchanger protein [Inorganic ion transport and metabolism].

28 Domain Motifs

Analysis Begin End Length Domain Identifier Cross Ref Description Inter Pro
Phobius 285 303 19 NON_CYTOPLASMIC_DOMAIN none Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region. none
Phobius 130 135 6 CYTOPLASMIC_DOMAIN none Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm. none
Phobius 68 78 11 CYTOPLASMIC_DOMAIN none Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm. none
Phobius 39 49 11 NON_CYTOPLASMIC_DOMAIN none Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region. none
Phobius 377 400 24 TRANSMEMBRANE none Region of a membrane-bound protein predicted to be embedded in the membrane. none
Phobius 179 200 22 TRANSMEMBRANE none Region of a membrane-bound protein predicted to be embedded in the membrane. none
Phobius 347 365 19 TRANSMEMBRANE none Region of a membrane-bound protein predicted to be embedded in the membrane. none
Phobius 401 488 88 CYTOPLASMIC_DOMAIN none Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm. none
Phobius 79 98 20 TRANSMEMBRANE none Region of a membrane-bound protein predicted to be embedded in the membrane. none
Phobius 18 38 21 TRANSMEMBRANE none Region of a membrane-bound protein predicted to be embedded in the membrane. none
Phobius 212 229 18 TRANSMEMBRANE none Region of a membrane-bound protein predicted to be embedded in the membrane. none
Phobius 366 376 11 NON_CYTOPLASMIC_DOMAIN none Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region. none
Phobius 1 17 17 CYTOPLASMIC_DOMAIN none Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm. none
Phobius 230 234 5 NON_CYTOPLASMIC_DOMAIN none Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region. none
Phobius 50 67 18 TRANSMEMBRANE none Region of a membrane-bound protein predicted to be embedded in the membrane. none
Phobius 265 284 20 TRANSMEMBRANE none Region of a membrane-bound protein predicted to be embedded in the membrane. none
PANTHER 1 488 488 PTHR10110 "Reactome:REACT_15518";signature_desc=SODIUM/HYDROGEN EXCHANGER none IPR018422
Phobius 201 211 11 CYTOPLASMIC_DOMAIN none Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm. none
Phobius 235 253 19 TRANSMEMBRANE none Region of a membrane-bound protein predicted to be embedded in the membrane. none
Phobius 160 178 19 NON_CYTOPLASMIC_DOMAIN none Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region. none
Phobius 99 109 11 NON_CYTOPLASMIC_DOMAIN none Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region. none
Phobius 110 129 20 TRANSMEMBRANE none Region of a membrane-bound protein predicted to be embedded in the membrane. none
Pfam 101 405 305 PF00999 none Sodium/hydrogen exchanger family IPR006153
Phobius 304 327 24 TRANSMEMBRANE none Region of a membrane-bound protein predicted to be embedded in the membrane. none
Phobius 254 264 11 CYTOPLASMIC_DOMAIN none Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm. none
Phobius 328 346 19 CYTOPLASMIC_DOMAIN none Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm. none
Phobius 136 159 24 TRANSMEMBRANE none Region of a membrane-bound protein predicted to be embedded in the membrane. none
PANTHER 1 488 488 PTHR10110:SF101 none none IPR029872

9 Localization

Analysis Start End Length
TMHMM 231 253 22
TMHMM 179 201 22
TMHMM 347 365 18
TMHMM 265 287 22
TMHMM 15 37 22
TMHMM 42 64 22
TMHMM 378 400 22
TMHMM 79 98 19
TMHMM 302 324 22

8 Qtllist

Qtl Name Chromosome Name Linkage Group Prox Marker Dist Marker Position QTL Pos One Pos Two Test Type Test Value R 2
Bourran2_2014_nSecLBD_3P Qrob_Chr08 8 s_1BN2OD_551 s_1B5AYF_599 17,17 0 43,51 lod 1,9229 4,4
Bourran2_2015_nEpiBC_3P Qrob_Chr12 12 s_1B73S5_217 v_7050_211 28,31 26,37 28,45 lod 4.5 11.6
Bourran2_2014_nLBD*_3P Qrob_Chr08 8 v_5216_549 v_11837_70 12,25 0 35,55 lod 2,5951 6
Bourran2_2014_nP*_3P Qrob_Chr08 8 v_5216_549 v_11837_70 12,19 0 31,97 lod 2,8472 6
Bourran2_2014_nPriLBD_3P Qrob_Chr08 8 v_5216_549 v_11837_70 12,36 0 30,43 lod 2,5806 5,1
Champenoux_2015_nSeqBC_A4 Qrob_Chr08 8 v_AD7YD13_501 s_1A7IED_780 43,44 43,42 43,99 lod 3.7 8.9
Bourran2_2014_nEpis*_3P Qrob_Chr08 8 s_1DA4QW_688 s_1DNI7D_820 17,96 0 37,75 lod 2,9745 7,5
Bourran2_2014_nPriBD_3P Qrob_Chr11 11 v_11486_194 s_1AT3E_2335 5,54 0,4 20,6 lod 2,6345 5,9

0 Targeting