Protein : Qrob_P0275690.2 Q. robur
Protein Identifier  ? Qrob_P0275690.2 Organism . Name  Quercus robur
Score  100.0 Score Type  egn
Protein Description  (M=7) PTHR10110:SF101 - SODIUM/HYDROGEN EXCHANGER 4 (PTHR10110:SF101) Gene Prediction Quality  validated
Protein length 

Sequence

Length: 521  
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0 Synonyms

11 GO Terms

Identifier Name Description
GO:0055085 transmembrane transport The process in which a solute is transported from one side of a membrane to the other.
GO:0016021 integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
GO:0006814 sodium ion transport The directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
GO:0015299 solute:proton antiporter activity Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + H+(in) = solute(in) + H+(out).
GO:0006885 regulation of pH Any process involved in the maintenance of an internal equilibrium of hydrogen ions, thereby modulating the internal pH, within an organism or cell.
GO:0015385 sodium:proton antiporter activity Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + H+(in) = Na+(in) + H+(out).
GO:0005774 vacuolar membrane The lipid bilayer surrounding the vacuole and separating its contents from the cytoplasm of the cell.
GO:0005886 plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
GO:0009651 response to salt stress Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of salt (particularly but not exclusively sodium and chloride ions) in the environment.
GO:0055075 potassium ion homeostasis Any process involved in the maintenance of an internal steady state of potassium ions within an organism or cell.

28 Blast

Analysis Hit Start End Strand Length Note Hit Coverage Hit Length Hit Pident E Val Hit Description
blastp_kegg lcl|tcc:TCM_021126 7 520 + 514 Gaps:22 98.71 543 83.58 0.0 Sodium/hydrogen exchanger
blastp_kegg lcl|pper:PRUPE_ppa003745mg 1 520 + 520 Gaps:31 100.00 551 81.49 0.0 hypothetical protein
blastp_kegg lcl|fve:101293187 1 520 + 520 Gaps:22 100.00 542 81.92 0.0 sodium/hydrogen exchanger 2-like
blastp_kegg lcl|vvi:100232960 1 520 + 520 Gaps:21 100.00 541 82.44 0.0 nhx1 antiporter
blastp_kegg lcl|cit:102615759 1 520 + 520 Gaps:21 99.63 543 80.78 0.0 sodium/hydrogen exchanger 2-like
blastp_kegg lcl|pop:POPTR_0010s03270g 17 520 + 504 Gaps:22 99.05 529 83.02 0.0 POPTRDRAFT_804767 Na+/H+ antiporter family protein
blastp_kegg lcl|pmum:103318539 1 520 + 520 Gaps:23 100.00 539 79.59 0.0 sodium/hydrogen exchanger 1
blastp_kegg lcl|pper:PRUPE_ppa003943mg 1 520 + 520 Gaps:23 100.00 539 79.59 0.0 hypothetical protein
blastp_kegg lcl|mdm:103416793 1 520 + 520 Gaps:31 100.00 551 79.85 0.0 sodium/hydrogen exchanger 2-like
blastp_kegg lcl|pxb:103958551 1 520 + 520 Gaps:31 100.00 551 79.31 0.0 sodium/hydrogen exchanger 2-like
blastp_uniprot_sprot sp|Q56XP4|NHX2_ARATH 10 514 + 505 Gaps:24 96.89 546 75.05 0.0 Sodium/hydrogen exchanger 2 OS Arabidopsis thaliana GN NHX2 PE 2 SV 2
blastp_uniprot_sprot sp|Q68KI4|NHX1_ARATH 7 514 + 508 Gaps:22 97.77 538 73.38 0.0 Sodium/hydrogen exchanger 1 OS Arabidopsis thaliana GN NHX1 PE 1 SV 2
blastp_uniprot_sprot sp|Q84WG1|NHX3_ARATH 1 484 + 484 Gaps:29 100.00 503 73.96 0.0 Sodium/hydrogen exchanger 3 OS Arabidopsis thaliana GN NHX3 PE 2 SV 2
blastp_uniprot_sprot sp|Q8S397|NHX4_ARATH 18 501 + 484 Gaps:32 95.65 529 59.09 0.0 Sodium/hydrogen exchanger 4 OS Arabidopsis thaliana GN NHX4 PE 2 SV 2
blastp_uniprot_sprot sp|Q8R4D1|SL9A8_MOUSE 13 425 + 413 Gaps:49 73.96 576 33.80 4e-55 Sodium/hydrogen exchanger 8 OS Mus musculus GN Slc9a8 PE 2 SV 1
blastp_uniprot_sprot sp|Q4L208|SL9A8_RAT 13 425 + 413 Gaps:49 74.09 575 33.80 7e-55 Sodium/hydrogen exchanger 8 OS Rattus norvegicus GN Slc9a8 PE 2 SV 1
blastp_uniprot_sprot sp|Q5ZJ75|SL9A8_CHICK 15 425 + 411 Gaps:55 74.22 574 34.51 9e-55 Sodium/hydrogen exchanger 8 OS Gallus gallus PE 2 SV 1
blastp_uniprot_sprot sp|Q9Y2E8|SL9A8_HUMAN 13 425 + 413 Gaps:63 73.32 581 34.04 2e-53 Sodium/hydrogen exchanger 8 OS Homo sapiens GN SLC9A8 PE 1 SV 4
blastp_uniprot_sprot sp|Q552S0|NHE1_DICDI 51 502 + 452 Gaps:78 62.31 674 33.33 4e-50 Sodium/hydrogen exchanger 1 OS Dictyostelium discoideum GN nhe1 PE 2 SV 1
blastp_uniprot_sprot sp|Q04121|NHX1_YEAST 47 381 + 335 Gaps:46 57.35 633 32.51 2e-44 Endosomal/prevacuolar sodium/hydrogen exchanger OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN NHX1 PE 1 SV 1
rpsblast_cdd gnl|CDD|162063 47 442 + 396 Gaps:54 71.56 559 30.50 1e-51 TIGR00840 b_cpa1 sodium/hydrogen exchanger 3. The Monovalent Cation:Proton Antiporter-1 (CPA1) Family (TC 2.A.36)The CPA1 family is a large family of proteins derived from Gram-positive and Gram-negative bacteria blue green bacteria yeast plants and animals.Transporters from eukaryotes have been functionally characterized and all of these catalyze Na+:H+ exchange. Their primary physiological functions may be in(1) cytoplasmic pH regulation extruding the H+ generated during metabolism and (2) salt tolerance (in plants) due to Na+ uptake into vacuoles.This Hmm is specific for the eukaryotic members members of this family.
rpsblast_cdd gnl|CDD|201544 83 419 + 337 Gaps:48 87.30 370 28.17 4e-31 pfam00999 Na_H_Exchanger Sodium/hydrogen exchanger family. Na/H antiporters are key transporters in maintaining the pH of actively metabolising cells. The molecular mechanisms of antiport are unclear. These antiporters contain 10-12 transmembrane regions (M) at the amino-terminus and a large cytoplasmic region at the carboxyl terminus. The transmembrane regions M3-M12 share identity with other members of the family. The M6 and M7 regions are highly conserved. Thus this is thought to be the region that is involved in the transport of sodium and hydrogen ions. The cytoplasmic region has little similarity throughout the family.
rpsblast_cdd gnl|CDD|30375 52 448 + 397 Gaps:33 93.24 429 23.00 2e-30 COG0025 NhaP NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism].
rpsblast_cdd gnl|CDD|129911 80 423 + 344 Gaps:36 68.57 525 21.11 1e-17 TIGR00831 a_cpa1 Na+/H+ antiporter bacterial form. The Monovalent Cation:Proton Antiporter-1 (CPA1) Family (TC 2.A.36) The CPA1 family is a large family of proteins derived from Gram-positive and Gram-negative bacteria blue green bacteria yeast plants and animals. Transporters from eukaryotes have been functionally characterized and all of these catalyze Na+:H+ exchange. Their primary physiological functions may be in (1) cytoplasmic pH regulation extruding the H+ generated during metabolism and (2) salt tolerance (in plants) due to Na+ uptake into vacuoles. This Hmm is specific for the bacterial members of this family.
rpsblast_cdd gnl|CDD|33074 93 425 + 333 Gaps:51 55.40 574 23.90 9e-09 COG3263 COG3263 NhaP-type Na+/H+ and K+/H+ antiporters with a unique C-terminal domain [Inorganic ion transport and metabolism].
rpsblast_cdd gnl|CDD|180017 167 381 + 215 Gaps:39 33.81 562 28.42 2e-08 PRK05326 PRK05326 potassium/proton antiporter Reviewed.
rpsblast_kog gnl|CDD|37176 17 515 + 499 Gaps:58 93.04 575 44.86 1e-135 KOG1965 KOG1965 KOG1965 Sodium/hydrogen exchanger protein [Inorganic ion transport and metabolism].
rpsblast_kog gnl|CDD|37177 46 498 + 453 Gaps:75 65.37 670 28.31 1e-45 KOG1966 KOG1966 KOG1966 Sodium/hydrogen exchanger protein [Inorganic ion transport and metabolism].

29 Domain Motifs

Analysis Begin End Length Domain Identifier Cross Ref Description Inter Pro
Phobius 137 155 19 NON_CYTOPLASMIC_DOMAIN none Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region. none
Pfam 35 423 389 PF00999 none Sodium/hydrogen exchanger family IPR006153
Phobius 240 265 26 TRANSMEMBRANE none Region of a membrane-bound protein predicted to be embedded in the membrane. none
Phobius 156 178 23 TRANSMEMBRANE none Region of a membrane-bound protein predicted to be embedded in the membrane. none
Phobius 198 220 23 TRANSMEMBRANE none Region of a membrane-bound protein predicted to be embedded in the membrane. none
Phobius 323 346 24 TRANSMEMBRANE none Region of a membrane-bound protein predicted to be embedded in the membrane. none
Phobius 73 83 11 NON_CYTOPLASMIC_DOMAIN none Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region. none
Phobius 84 101 18 TRANSMEMBRANE none Region of a membrane-bound protein predicted to be embedded in the membrane. none
Phobius 418 520 103 CYTOPLASMIC_DOMAIN none Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm. none
Phobius 221 239 19 NON_CYTOPLASMIC_DOMAIN none Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region. none
PRINTS 113 121 9 PR01084 "Reactome:REACT_15518" Na+/H+ exchanger signature IPR004709
PRINTS 84 95 12 PR01084 "Reactome:REACT_15518" Na+/H+ exchanger signature IPR004709
PRINTS 98 112 15 PR01084 "Reactome:REACT_15518" Na+/H+ exchanger signature IPR004709
Phobius 20 43 24 TRANSMEMBRANE none Region of a membrane-bound protein predicted to be embedded in the membrane. none
Phobius 44 54 11 CYTOPLASMIC_DOMAIN none Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm. none
Phobius 285 303 19 TRANSMEMBRANE none Region of a membrane-bound protein predicted to be embedded in the membrane. none
Phobius 55 72 18 TRANSMEMBRANE none Region of a membrane-bound protein predicted to be embedded in the membrane. none
Phobius 266 284 19 CYTOPLASMIC_DOMAIN none Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm. none
Phobius 397 417 21 TRANSMEMBRANE none Region of a membrane-bound protein predicted to be embedded in the membrane. none
Phobius 179 197 19 CYTOPLASMIC_DOMAIN none Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm. none
Phobius 366 385 20 TRANSMEMBRANE none Region of a membrane-bound protein predicted to be embedded in the membrane. none
Phobius 1 19 19 NON_CYTOPLASMIC_DOMAIN none Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region. none
Phobius 113 136 24 TRANSMEMBRANE none Region of a membrane-bound protein predicted to be embedded in the membrane. none
Phobius 304 322 19 NON_CYTOPLASMIC_DOMAIN none Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region. none
Phobius 386 396 11 NON_CYTOPLASMIC_DOMAIN none Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region. none
Phobius 102 112 11 CYTOPLASMIC_DOMAIN none Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm. none
PANTHER 1 502 502 PTHR10110:SF101 none none IPR029872
Phobius 347 365 19 CYTOPLASMIC_DOMAIN none Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm. none
PANTHER 1 502 502 PTHR10110 "Reactome:REACT_15518";signature_desc=SODIUM/HYDROGEN EXCHANGER none IPR018422

11 Localization

Analysis Start End Length
TMHMM 247 269 22
TMHMM 198 220 22
TMHMM 114 136 22
TMHMM 156 178 22
TMHMM 284 301 17
TMHMM 322 344 22
TMHMM 393 415 22
TMHMM 77 99 22
TMHMM 53 72 19
TMHMM 364 386 22
TMHMM 21 43 22

14 Qtllist

Qtl Name Chromosome Name Linkage Group Prox Marker Dist Marker Position QTL Pos One Pos Two Test Type Test Value R 2
Bourran2_2014_nSecLBD_3P Qrob_Chr08 8 s_1BN2OD_551 s_1B5AYF_599 17,17 0 43,51 lod 1,9229 4,4
Bourran2_2014_nLBD*_3P Qrob_Chr08 8 v_5216_549 v_11837_70 12,25 0 35,55 lod 2,5951 6
Bourran2_2014_nP*_3P Qrob_Chr08 8 v_5216_549 v_11837_70 12,19 0 31,97 lod 2,8472 6
Bourran2_2002_QTL11_peak_Bud_burst_A4 Qrob_Chr06 6 s_1C41PA_791 s_1AM1AV_1141 19,17 0 34,57 lod 2,3 2,9
Bourran2_2014_nEpis*_3P Qrob_Chr08 8 s_1DA4QW_688 s_1DNI7D_820 17,96 0 37,75 lod 2,9745 7,5
Bourran2_2014_nEpis*_A4 Qrob_Chr07 7 v_12400_446 s_1BPEBU_1211 6,93 0 15,13 lod 4,7411 11
Bourran2_2014_nFork*_3P Qrob_Chr06 6 v_12930_125 s_1AMZEI_909 34,28 7,43 41,48 lod 2,4044 5,5
Bourran2_2014_nLBD_A4 Qrob_Chr06 6 v_12930_125 s_1AMZEI_909 37,41 9,8 50,1 lod 1,9524 4,1
Bourran2_2014_nPriBD_A4 Qrob_Chr06 6 v_12930_125 s_1AMZEI_909 34,51 3,36 51,86 lod 1,6747 3,9
Bourran2_2014_nPriLBD*_3P Qrob_Chr11 11 v_12066_307 s_1B15GJ_447 3,37 0,57 16,17 lod 3,4299 6,9
Bourran2_2014_nSecLBD_A4 Qrob_Chr07 7 v_8327_222 s_1A4WGY_363 16,04 0 44,69 lod 2,6373 6,5
Champenoux_2015_nEpis_3P Qrob_Chr11 11 s_1DG9PM_867 s_1BZ083_1312 26,53 25,47 27,72 lod 4.4 8.9
Champenoux_2015_nP_3P Qrob_Chr06 6 s_1A386O_228 s_1AYZFS_603 27,03 26,47 27,34 lod 2.8 7.2
Bourran2_2014_nPriBD*_3P Qrob_Chr06 6 s_1B6WLL_980 v_10064_133 11,49 0 31,52 lod 4,1208 9,1

1 Targeting

Analysis Start End Length Location Reliability Signal Peptide Cut Off Mitochondrion Cut Off Network Signal Peptide Length
TargetP 1 40   Secretory pathway 4 0.793 0.022 NON-PLANT 40