GO Term : GO:0004421 hydroxymethylglutaryl-CoA synthase activity GO

Namespace  molecular_function Obsolete  false
description  Catalysis of the reaction: acetoacetyl-CoA + acetyl-CoA + H(2)O = (S)-3-hydroxy-3-methylglutaryl-CoA + CoA + H(+).

0 Cross References

1 Ontology

Name
GO

6 Parents

Identifier Name Description
GO:0003824 catalytic activity Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic.
GO:0016746 transferase activity, transferring acyl groups Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor).
GO:0016740 transferase activity Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2.
GO:0046912 transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor), with the acyl group being converted into alkyl on transfer.
GO:0004421 hydroxymethylglutaryl-CoA synthase activity Catalysis of the reaction: acetoacetyl-CoA + acetyl-CoA + H(2)O = (S)-3-hydroxy-3-methylglutaryl-CoA + CoA + H(+).
GO:0003674 molecular_function Elemental activities, such as catalysis or binding, describing the actions of a gene product at the molecular level. A given gene product may exhibit one or more molecular functions.

1 Protein

Protein Identifier
Organism . Name
Score Score Type Protein Description Alias (in v1) Code Enzyme Gene Prediction Quality
Qrob_P0477570.2 Quercus robur 100.0 egn (M=1) 2.3.3.10 - Hydroxymethylglutaryl-CoA synthase.   EC:2.3.3.10 validated

5 Relations

Relationship
Parent Term . Identifier

Child Term . Identifier
is_a GO:0046912 GO:0004421
is_a GO:0016740 GO:0004421
is_a GO:0003674 GO:0004421
is_a GO:0016746 GO:0004421
is_a GO:0003824 GO:0004421

14 Synonyms

Name Type
3-hydroxy-3-methylglutaryl-coenzyme A synthase activity synonym
acetoacetyl coenzyme A transacetase activity synonym
3-hydroxy-3-methylglutaryl coenzyme A synthetase activity synonym
3-hydroxy-3-methylglutaryl-CoA synthase activity synonym
HMG-CoA synthase activity synonym
hydroxymethylglutaryl coenzyme A synthase activity synonym
acetyl-CoA:acetoacetyl-CoA C-acetyltransferase (thioester-hydrolysing, carboxymethyl-forming) synonym
beta-hydroxy-beta-methylglutaryl-CoA synthase activity synonym
hydroxymethylglutaryl coenzyme alpha-condensing enzyme activity synonym
hydroxymethylglutaryl coenzyme A-condensing enzyme synonym
3-hydroxy-3-methylglutaryl CoA synthetase activity synonym
3-hydroxy-3-methylglutaryl coenzyme A synthase activity synonym
(s)-3-hydroxy-3-methylglutaryl-CoA acetoacetyl-CoA-lyase (CoA- acetylating) activity synonym
(S)-3-hydroxy-3-methylglutaryl-CoA acetoacetyl-CoA-lyase (CoA-acetylating) synonym