Protein : Qrob_P0477570.2 Q. robur
Protein Identifier  ? Qrob_P0477570.2 Organism . Name  Quercus robur
Score  100.0 Score Type  egn
Protein Description  (M=1) 2.3.3.10 - Hydroxymethylglutaryl-CoA synthase. Code Enzyme  EC:2.3.3.10
Gene Prediction Quality  validated Protein length 

Sequence

Length: 469  
Kegg Orthology  K01641
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0 Synonyms

4 GO Terms

Identifier Name Description
GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation.
GO:0003824 catalytic activity Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic.
GO:0008299 isoprenoid biosynthetic process The chemical reactions and pathways resulting in the formation of any isoprenoid compound, isoprene (2-methylbuta-1,3-diene) or compounds containing or derived from linked isoprene (3-methyl-2-butenylene) residues.
GO:0004421 hydroxymethylglutaryl-CoA synthase activity Catalysis of the reaction: acetoacetyl-CoA + acetyl-CoA + H(2)O = (S)-3-hydroxy-3-methylglutaryl-CoA + CoA + H(+).

41 Blast

Analysis Hit Start End Strand Length Note Hit Coverage Hit Length Hit Pident E Val Hit Description
blastp_kegg lcl|tcc:TCM_016163 1 468 + 468 Gaps:3 100.00 465 89.46 0.0 Hydroxymethylglutaryl-CoA synthase / HMG-CoA synthase / 3-hydroxy-3-methylglutaryl coenzyme A synthase
blastp_kegg lcl|cic:CICLE_v10020042mg 1 468 + 468 Gaps:3 100.00 465 87.31 0.0 hypothetical protein
blastp_kegg lcl|cit:102629096 1 468 + 468 Gaps:3 100.00 465 86.88 0.0 hydroxymethylglutaryl-CoA synthase-like
blastp_kegg lcl|pop:POPTR_0003s12030g 1 468 + 468 Gaps:4 100.00 464 87.93 0.0 POPTRDRAFT_646543 hypothetical protein
blastp_kegg lcl|rcu:RCOM_1683050 1 468 + 468 Gaps:4 100.00 464 86.85 0.0 hydroxymethylglutaryl-CoA synthase putative (EC:2.3.3.10)
blastp_kegg lcl|gmx:100782595 1 467 + 467 Gaps:1 98.11 475 86.05 0.0 hydroxymethylglutaryl-CoA synthase-like
blastp_kegg lcl|pmum:103337386 1 468 + 468 Gaps:1 100.00 469 85.93 0.0 hydroxymethylglutaryl-CoA synthase
blastp_kegg lcl|pper:PRUPE_ppa005266mg 1 468 + 468 Gaps:1 100.00 469 85.71 0.0 hypothetical protein
blastp_kegg lcl|vvi:100244379 1 468 + 468 Gaps:4 100.00 464 85.56 0.0 hydroxymethylglutaryl-CoA synthase-like
blastp_kegg lcl|pop:POPTR_0001s08600g 1 468 + 468 Gaps:4 100.00 464 87.28 0.0 POPTRDRAFT_548531 hypothetical protein
blastp_pdb 2fa3_A 2 449 + 448 Gaps:2 100.00 450 85.78 0.0 mol:protein length:450 HMG-CoA synthase
blastp_pdb 2fa0_A 2 449 + 448 Gaps:2 100.00 450 85.78 0.0 mol:protein length:450 HMG-CoA synthase
blastp_pdb 2f9a_A 2 449 + 448 Gaps:2 100.00 450 85.78 0.0 mol:protein length:450 3-Hydroxy-3-methylglutaryl coenzyme A synthas
blastp_pdb 2f82_A 2 449 + 448 Gaps:2 100.00 450 85.78 0.0 mol:protein length:450 HMG-CoA synthase
blastp_pdb 2p8u_B 4 449 + 446 Gaps:8 94.98 478 50.44 2e-154 mol:protein length:478 Hydroxymethylglutaryl-CoA synthase cytoplasm
blastp_pdb 2p8u_A 4 449 + 446 Gaps:8 94.98 478 50.44 2e-154 mol:protein length:478 Hydroxymethylglutaryl-CoA synthase cytoplasm
blastp_pdb 2wya_D 1 449 + 449 Gaps:8 99.35 460 48.14 7e-154 mol:protein length:460 HYDROXYMETHYLGLUTARYL-COA SYNTHASE MITOCHOND
blastp_pdb 2wya_C 1 449 + 449 Gaps:8 99.35 460 48.14 7e-154 mol:protein length:460 HYDROXYMETHYLGLUTARYL-COA SYNTHASE MITOCHOND
blastp_pdb 2wya_B 1 449 + 449 Gaps:8 99.35 460 48.14 7e-154 mol:protein length:460 HYDROXYMETHYLGLUTARYL-COA SYNTHASE MITOCHOND
blastp_pdb 2wya_A 1 449 + 449 Gaps:8 99.35 460 48.14 7e-154 mol:protein length:460 HYDROXYMETHYLGLUTARYL-COA SYNTHASE MITOCHOND
blastp_uniprot_sprot sp|P54873|HMCS_ARATH 1 468 + 468 Gaps:11 100.00 461 82.65 0.0 Hydroxymethylglutaryl-CoA synthase OS Arabidopsis thaliana GN HMGS PE 1 SV 2
blastp_uniprot_sprot sp|P54872|HMCSA_DICDI 3 448 + 446 Gaps:8 90.87 482 51.14 1e-157 Hydroxymethylglutaryl-CoA synthase A OS Dictyostelium discoideum GN hgsA PE 1 SV 2
blastp_uniprot_sprot sp|P54961|HMCS1_BLAGE 4 451 + 448 Gaps:11 99.12 453 50.56 6e-155 Hydroxymethylglutaryl-CoA synthase 1 OS Blattella germanica GN HMGCS-1 PE 2 SV 1
blastp_uniprot_sprot sp|Q5R7Z9|HMCS1_PONAB 3 449 + 447 Gaps:8 87.50 520 50.55 1e-153 Hydroxymethylglutaryl-CoA synthase cytoplasmic OS Pongo abelii GN HMGCS1 PE 2 SV 1
blastp_uniprot_sprot sp|Q01581|HMCS1_HUMAN 3 449 + 447 Gaps:8 87.50 520 50.55 3e-153 Hydroxymethylglutaryl-CoA synthase cytoplasmic OS Homo sapiens GN HMGCS1 PE 1 SV 2
blastp_uniprot_sprot sp|P54868|HMCS2_HUMAN 3 449 + 447 Gaps:8 89.57 508 48.13 5e-152 Hydroxymethylglutaryl-CoA synthase mitochondrial OS Homo sapiens GN HMGCS2 PE 1 SV 1
blastp_uniprot_sprot sp|Q8JZK9|HMCS1_MOUSE 3 449 + 447 Gaps:10 87.50 520 50.55 9e-152 Hydroxymethylglutaryl-CoA synthase cytoplasmic OS Mus musculus GN Hmgcs1 PE 1 SV 1
blastp_uniprot_sprot sp|P17425|HMCS1_RAT 3 449 + 447 Gaps:10 87.50 520 50.11 5e-151 Hydroxymethylglutaryl-CoA synthase cytoplasmic OS Rattus norvegicus GN Hmgcs1 PE 1 SV 1
blastp_uniprot_sprot sp|P54869|HMCS2_MOUSE 3 448 + 446 Gaps:8 89.37 508 48.68 7e-151 Hydroxymethylglutaryl-CoA synthase mitochondrial OS Mus musculus GN Hmgcs2 PE 1 SV 2
blastp_uniprot_sprot sp|P22791|HMCS2_RAT 3 449 + 447 Gaps:8 89.57 508 48.13 4e-150 Hydroxymethylglutaryl-CoA synthase mitochondrial OS Rattus norvegicus GN Hmgcs2 PE 2 SV 1

11 Domain Motifs

Analysis Begin End Length Domain Identifier Cross Ref Description Inter Pro
ProSitePatterns 105 120 16 PS01226 "KEGG:00072+2.3.3.10","KEGG:00280+2.3.3.10","KEGG:00650+2.3.3.10","KEGG:00900+2.3.3.10","MetaCyc:PWY-6174","MetaCyc:PWY-7391","MetaCyc:PWY-7524","MetaCyc:PWY-7571","MetaCyc:PWY-922","Reactome:REACT_22258","UniPathway:UPA00058" Hydroxymethylglutaryl-coenzyme A synthase active site. IPR000590
Pfam 175 449 275 PF08540 "KEGG:00072+2.3.3.10","KEGG:00280+2.3.3.10","KEGG:00650+2.3.3.10","KEGG:00900+2.3.3.10","MetaCyc:PWY-6174","MetaCyc:PWY-7391","MetaCyc:PWY-7524","MetaCyc:PWY-7571","MetaCyc:PWY-922","Reactome:REACT_22258","UniPathway:UPA00058" Hydroxymethylglutaryl-coenzyme A synthase C terminal IPR013746
PANTHER 3 454 452 PTHR11877 none none none
Pfam 2 174 173 PF01154 "Reactome:REACT_22258" Hydroxymethylglutaryl-coenzyme A synthase N terminal IPR013528
SUPERFAMILY 4 172 169 SSF53901 none none IPR016039
SUPERFAMILY 176 262 87 SSF53901 none none IPR016039
SUPERFAMILY 300 447 148 SSF53901 none none IPR016039
PANTHER 3 454 452 PTHR11877:SF10 none none none
Gene3D 299 370 72 G3DSA:3.40.47.10 none none IPR016038
TIGRFAM 2 449 448 TIGR01833 "KEGG:00072+2.3.3.10","KEGG:00280+2.3.3.10","KEGG:00650+2.3.3.10","KEGG:00900+2.3.3.10","MetaCyc:PWY-6174","MetaCyc:PWY-7391","MetaCyc:PWY-7524","MetaCyc:PWY-7571","MetaCyc:PWY-922","Reactome:REACT_22258","UniPathway:UPA00058" HMG-CoA-S_euk: hydroxymethylglutaryl-CoA synthase IPR010122
Gene3D 3 266 264 G3DSA:3.40.47.10 none none IPR016038

0 Localization

4 Qtllist

Qtl Name Chromosome Name Linkage Group Prox Marker Dist Marker Position QTL Pos One Pos Two Test Type Test Value R 2
Bourran2_2015_nEpiBC_3P Qrob_Chr12 12 s_1B73S5_217 v_7050_211 28,31 26,37 28,45 lod 4.5 11.6
Bourran2_2015_nP_3P Qrob_Chr12 12 v_10140_295 v_838_303 16 14,69 18,01 lod 5.1 13.7
Bourran2_2015_nSecLBD_3P Qrob_Chr12 12 s_A4YYC_633 s_2F1IZB_703 18,64 18,01 21,53 lod 6.5 17.2
Bourran2_2014_nSeqBC_3P Qrob_Chr12 12 s_1EO8V5_710 s_1A2VMU_355 11,04 0 32,58 lod 1,7196 4,7

0 Targeting