GO Term : GO:0005786 signal recognition particle, endoplasmic reticulum targeting GO

Namespace  cellular_component Obsolete  false
description  A ribonucleoprotein particle of 325 kDa composed of a 7S (300 nucleotide) RNA molecule and a complex of six different polypeptides. This binds both to the N-terminal signal peptide for proteins destined for the endoplasmic reticulum as they emerge from the large ribosomal subunit and also to the ribosome. This binding arrests further translation thereby preventing the proteins from being released into the cytosol. The SRP-ribosome complex then diffuses to the endoplasmic reticulum where it is bound to the signal recognition particle receptor, which allows resumption of protein synthesis and facilitates the passage of the growing polypeptide chain through the translocon. Through a process involving GTP hydrolysis, the SRP-SRP receptor complex dissociates and SRP returns to the cytosol. Of the six polypeptides of SRP the 54 kDa subunit (SRP54) is the central player. It contains an N-terminal GTPase domain and a C-terminal domain that binds directly to the signal peptide and the SRP RNA. Examples of this component are found in Mus musculus, Saccharomyces cerevisiae and Arabidopsis thaliana.

0 Cross References

1 Ontology

Name
GO

11 Parents

Identifier Name Description
GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm.
GO:0030529 ribonucleoprotein complex A macromolecular complex containing both protein and RNA molecules.
GO:0048500 signal recognition particle A complex of protein and RNA which facilitates translocation of proteins across membranes.
GO:0005786 signal recognition particle, endoplasmic reticulum targeting A ribonucleoprotein particle of 325 kDa composed of a 7S (300 nucleotide) RNA molecule and a complex of six different polypeptides. This binds both to the N-terminal signal peptide for proteins destined for the endoplasmic reticulum as they emerge from the large ribosomal subunit and also to the ribosome. This binding arrests further translation thereby preventing the proteins from being released into the cytosol. The SRP-ribosome complex then diffuses to the endoplasmic reticulum where it is bound to the signal recognition particle receptor, which allows resumption of protein synthesis and facilitates the passage of the growing polypeptide chain through the translocon. Through a process involving GTP hydrolysis, the SRP-SRP receptor complex dissociates and SRP returns to the cytosol. Of the six polypeptides of SRP the 54 kDa subunit (SRP54) is the central player. It contains an N-terminal GTPase domain and a C-terminal domain that binds directly to the signal peptide and the SRP RNA. Examples of this component are found in Mus musculus, Saccharomyces cerevisiae and Arabidopsis thaliana.
GO:0044424 intracellular part Any constituent part of the living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm.
GO:0005623 cell The basic structural and functional unit of all organisms. Includes the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope.
GO:0032991 macromolecular complex A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which the constituent parts function together.
GO:0044464 cell part Any constituent part of a cell, the basic structural and functional unit of all organisms.
GO:0005575 cellular_component The part of a cell or its extracellular environment in which a gene product is located. A gene product may be located in one or more parts of a cell and its location may be as specific as a particular macromolecular complex, that is, a stable, persistent association of macromolecules that function together.
GO:0044444 cytoplasmic part Any constituent part of the cytoplasm, all of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

2 Protein

Protein Identifier
Organism . Name
Score Score Type Protein Description Alias (in v1) Code Enzyme Gene Prediction Quality
Qrob_P0040700.2 Quercus robur 0.0 egn (M=1) K03104 - signal recognition particle subunit SRP14     validated
Qrob_P0488980.2 Quercus robur 36.0 egn (M=2) PTHR12013 - SIGNAL RECOGNITION PARTICLE 14 KD PROTEIN     validated

13 Relations

Relationship
Parent Term . Identifier

Child Term . Identifier
is_a GO:0048500 GO:0005786
part of GO:0044424 GO:0005786
part of GO:0005623 GO:0005786
is_a GO:0032991 GO:0005786
part of GO:0005622 GO:0005786
is_a GO:0044424 GO:0005786
part of GO:0005575 GO:0005786
is_a GO:0005575 GO:0005786
is_a GO:0044464 GO:0005786
is_a GO:0030529 GO:0005786
part of GO:0005737 GO:0005786
is_a GO:0044444 GO:0005786
part of GO:0044464 GO:0005786

3 Synonyms

Name Type
signal sequence receptor complex synonym
SRP synonym
GO:0005855 alt_id