Protein : Qrob_P0447810.2 Q. robur
Protein Identifier  ? Qrob_P0447810.2 Organism . Name  Quercus robur
Score  0.0 Score Type  egn
Protein Description  (M=9) K10878 - meiotic recombination protein SPO11 Code Enzyme  EC:5.99.1.3
Gene Prediction Quality  validated Protein length 

Sequence

Length: 338  
Kegg Orthology  K10878
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0 Synonyms

6 GO Terms

Identifier Name Description
GO:0003677 DNA binding Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
GO:0005524 ATP binding Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
GO:0003824 catalytic activity Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic.
GO:0005694 chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information.
GO:0006259 DNA metabolic process Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides.
GO:0000737 DNA catabolic process, endonucleolytic The chemical reactions and pathways resulting in the breakdown of DNA, involving the hydrolysis of internal 3',5'-phosphodiester bonds in one or two strands of deoxyribonucleotides.

33 Blast

Analysis Hit Start End Strand Length Note Hit Coverage Hit Length Hit Pident E Val Hit Description
blastp_kegg lcl|vvi:100256655 1 332 + 332 Gaps:24 98.61 361 76.12 0.0 meiotic recombination protein SPO11-1-like
blastp_kegg lcl|fve:101293370 1 337 + 337 Gaps:28 100.00 365 70.96 0.0 meiotic recombination protein SPO11-1-like
blastp_kegg lcl|pop:POPTR_0001s37540g 1 331 + 331 Gaps:27 96.44 365 72.73 0.0 POPTRDRAFT_550198 DNA topoisomerase VIA family protein
blastp_kegg lcl|pmum:103342724 1 337 + 337 Gaps:28 100.00 365 71.78 0.0 meiotic recombination protein SPO11-1
blastp_kegg lcl|gmx:100813920 1 335 + 335 Gaps:30 99.46 367 69.04 0.0 meiotic recombination protein SPO11-1-like
blastp_kegg lcl|pxb:103941907 12 337 + 326 Gaps:25 95.90 366 72.36 7e-180 meiotic recombination protein SPO11-1-like
blastp_kegg lcl|pxb:103965437 12 337 + 326 Gaps:25 95.90 366 72.36 7e-180 meiotic recombination protein SPO11-1-like
blastp_kegg lcl|cam:101504128 1 337 + 337 Gaps:31 100.00 354 70.90 3e-177 meiotic recombination protein SPO11-1-like
blastp_kegg lcl|mdm:103448311 1 337 + 337 Gaps:28 100.00 365 69.86 2e-176 meiotic recombination protein SPO11-1
blastp_kegg lcl|sot:102586801 1 334 + 334 Gaps:24 98.90 362 67.88 2e-174 meiotic recombination protein SPO11-1-like
blastp_pdb 2zbk_G 92 337 + 246 Gaps:30 67.35 389 33.59 2e-32 mol:protein length:389 Type II DNA topoisomerase VI subunit A
blastp_pdb 2zbk_E 92 337 + 246 Gaps:30 67.35 389 33.59 2e-32 mol:protein length:389 Type II DNA topoisomerase VI subunit A
blastp_pdb 2zbk_C 92 337 + 246 Gaps:30 67.35 389 33.59 2e-32 mol:protein length:389 Type II DNA topoisomerase VI subunit A
blastp_pdb 2zbk_A 92 337 + 246 Gaps:30 67.35 389 33.59 2e-32 mol:protein length:389 Type II DNA topoisomerase VI subunit A
blastp_pdb 1d3y_B 84 332 + 249 Gaps:23 87.71 301 29.17 8e-27 mol:protein length:301 DNA TOPOISOMERASE VI A SUBUNIT
blastp_pdb 1d3y_A 84 332 + 249 Gaps:23 87.71 301 29.17 8e-27 mol:protein length:301 DNA TOPOISOMERASE VI A SUBUNIT
blastp_pdb 2q2e_A 74 332 + 259 Gaps:24 73.98 369 25.64 6e-19 mol:protein length:369 Type II DNA topoisomerase VI subunit A
blastp_uniprot_sprot sp|Q9M4A2|SPO11_ARATH 1 335 + 335 Gaps:24 99.17 362 64.35 3e-169 Meiotic recombination protein SPO11-1 OS Arabidopsis thaliana GN SPO11-1 PE 1 SV 1
blastp_uniprot_sprot sp|Q9Y5K1|SPO11_HUMAN 3 334 + 332 Gaps:33 90.15 396 32.77 7e-62 Meiotic recombination protein SPO11 OS Homo sapiens GN SPO11 PE 2 SV 1
blastp_uniprot_sprot sp|Q9LZ03|TOP6A_ARATH 76 332 + 257 Gaps:10 62.06 427 38.49 7e-61 DNA topoisomerase 6 subunit A OS Arabidopsis thaliana GN TOP6A PE 1 SV 1
blastp_uniprot_sprot sp|Q9WTK8|SPO11_MOUSE 62 334 + 273 Gaps:15 71.72 396 34.86 1e-59 Meiotic recombination protein SPO11 OS Mus musculus GN Spo11 PE 2 SV 2
blastp_uniprot_sprot sp|A2XFC1|TOP6A_ORYSI 35 332 + 298 Gaps:20 67.87 442 37.67 3e-58 DNA topoisomerase 6 subunit A OS Oryza sativa subsp. indica GN TOP6A PE 2 SV 2
blastp_uniprot_sprot sp|Q22236|SPO11_CAEEL 76 328 + 253 Gaps:24 60.00 425 35.29 4e-41 Meiotic recombination protein spo-11 OS Caenorhabditis elegans GN spo-11 PE 3 SV 1
blastp_uniprot_sprot sp|Q9M4A1|SPO12_ARATH 76 337 + 262 Gaps:18 71.02 383 33.46 3e-36 Meiotic recombination protein SPO11-2 OS Arabidopsis thaliana GN SPO11-2 PE 1 SV 1
blastp_uniprot_sprot sp|Q9YE67|TOP6A_AERPE 76 334 + 259 Gaps:42 74.81 389 30.24 1e-34 Type 2 DNA topoisomerase 6 subunit A OS Aeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1) GN top6A PE 3 SV 2
blastp_uniprot_sprot sp|A2BLE8|TOP6A_HYPBU 78 334 + 257 Gaps:37 74.42 387 30.56 4e-33 Type 2 DNA topoisomerase 6 subunit A OS Hyperthermus butylicus (strain DSM 5456 / JCM 9403) GN top6A PE 3 SV 1
blastp_uniprot_sprot sp|O05208|TOP6A_SULSH 92 337 + 246 Gaps:30 67.35 389 33.59 7e-32 Type 2 DNA topoisomerase 6 subunit A OS Sulfolobus shibatae GN top6A PE 1 SV 1
rpsblast_cdd gnl|CDD|31883 4 331 + 328 Gaps:32 98.88 356 30.68 3e-51 COG1697 COG1697 DNA topoisomerase VI subunit A [DNA replication recombination and repair].
rpsblast_cdd gnl|CDD|179833 77 334 + 258 Gaps:26 74.11 367 30.51 8e-50 PRK04342 PRK04342 DNA topoisomerase VI subunit A Provisional.
rpsblast_cdd gnl|CDD|173774 168 321 + 154 Gaps:12 100.00 160 48.75 2e-49 cd00223 TOPRIM_TopoIIB_SPO TOPRIM_TopoIIB_SPO: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in the type IIB family of DNA topoisomerases and Spo11. This subgroup contains proteins similar to Sulfolobus shibatae topoisomerase VI (TopoVI) and Saccharomyces cerevisiae meiotic recombination factor: Spo11. Type II DNA topoisomerases catalyze the ATP-dependent transport of one DNA duplex through another in the process generating transient double strand breaks via covalent attachments to both DNA strands at the 5' positions. TopoVI enzymes are heterotetramers found in archaea and plants. Spo11 plays a role in generating the double strand breaks that initiate homologous recombination during meiosis. S. shibatae TopoVI relaxes both positive and negative supercoils and in addition has a strong decatenase activity. The TOPRIM domain has two conserved motifs one of which centers at a conserved glutamate and the other one at two conserved aspartates (DxD. For topoisomerases the conserved glutamate is believed to act as a general base in strand joining and as a general acid in strand cleavage. The DXD motif may co-ordinate Mg2+ a cofactor required for full catalytic function.

16 Domain Motifs

Analysis Begin End Length Domain Identifier Cross Ref Description Inter Pro
Gene3D 125 333 209 G3DSA:3.40.1360.10 none none none
Gene3D 77 122 46 G3DSA:1.10.10.10 none none IPR011991
PANTHER 13 337 325 PTHR10848:SF3 none none none
Pfam 76 121 46 PF04406 none Type IIB DNA topoisomerase IPR013049
PRINTS 89 109 21 PR01551 none SPO11 homologue signature IPR013048
PRINTS 184 199 16 PR01551 none SPO11 homologue signature IPR013048
PRINTS 231 250 20 PR01551 none SPO11 homologue signature IPR013048
PRINTS 266 290 25 PR01551 none SPO11 homologue signature IPR013048
SUPERFAMILY 73 333 261 SSF56726 none none IPR002815
PANTHER 13 337 325 PTHR10848 none none IPR002815
PRINTS 170 187 18 PR01550 none DNA topoisomerase VI subunit A family signature IPR002815
PRINTS 97 114 18 PR01550 none DNA topoisomerase VI subunit A family signature IPR002815
PRINTS 226 242 17 PR01550 none DNA topoisomerase VI subunit A family signature IPR002815
PRINTS 83 94 12 PR01550 none DNA topoisomerase VI subunit A family signature IPR002815
PRINTS 115 130 16 PR01550 none DNA topoisomerase VI subunit A family signature IPR002815
PRINTS 194 215 22 PR01550 none DNA topoisomerase VI subunit A family signature IPR002815

0 Localization

8 Qtllist

Qtl Name Chromosome Name Linkage Group Prox Marker Dist Marker Position QTL Pos One Pos Two Test Type Test Value R 2
Bourran2_2014_nSecLBD_3P Qrob_Chr08 8 s_1BN2OD_551 s_1B5AYF_599 17,17 0 43,51 lod 1,9229 4,4
Bourran2_2015_nEpiBC_3P Qrob_Chr12 12 s_1B73S5_217 v_7050_211 28,31 26,37 28,45 lod 4.5 11.6
Bourran2_2014_nLBD*_3P Qrob_Chr08 8 v_5216_549 v_11837_70 12,25 0 35,55 lod 2,5951 6
Bourran2_2014_nP*_3P Qrob_Chr08 8 v_5216_549 v_11837_70 12,19 0 31,97 lod 2,8472 6
Bourran2_2014_nPriLBD_3P Qrob_Chr08 8 v_5216_549 v_11837_70 12,36 0 30,43 lod 2,5806 5,1
Champenoux_2015_nSeqBC_A4 Qrob_Chr08 8 v_AD7YD13_501 s_1A7IED_780 43,44 43,42 43,99 lod 3.7 8.9
Bourran2_2014_nEpis*_3P Qrob_Chr08 8 s_1DA4QW_688 s_1DNI7D_820 17,96 0 37,75 lod 2,9745 7,5
Bourran2_2014_nPriBD_3P Qrob_Chr11 11 v_11486_194 s_1AT3E_2335 5,54 0,4 20,6 lod 2,6345 5,9

0 Targeting