Protein : Qrob_P0447720.2 Q. robur
Protein Identifier  ? Qrob_P0447720.2 Organism . Name  Quercus robur
Score  0.0 Score Type  egn
Protein Description  (M=9) K10878 - meiotic recombination protein SPO11 Code Enzyme  EC:5.99.1.3
Gene Prediction Quality  validated Protein length 

Sequence

Length: 349  
Kegg Orthology  K10878
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0 Synonyms

6 GO Terms

Identifier Name Description
GO:0003677 DNA binding Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
GO:0005524 ATP binding Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
GO:0003824 catalytic activity Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic.
GO:0005694 chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information.
GO:0006259 DNA metabolic process Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides.
GO:0000737 DNA catabolic process, endonucleolytic The chemical reactions and pathways resulting in the breakdown of DNA, involving the hydrolysis of internal 3',5'-phosphodiester bonds in one or two strands of deoxyribonucleotides.

33 Blast

Analysis Hit Start End Strand Length Note Hit Coverage Hit Length Hit Pident E Val Hit Description
blastp_kegg lcl|pop:POPTR_0001s37540g 43 342 + 300 Gaps:23 80.27 365 77.47 3e-157 POPTRDRAFT_550198 DNA topoisomerase VIA family protein
blastp_kegg lcl|gmx:100813920 46 346 + 301 Gaps:23 80.11 367 74.83 1e-152 meiotic recombination protein SPO11-1-like
blastp_kegg lcl|pmum:103342724 46 348 + 303 Gaps:23 81.10 365 76.01 2e-152 meiotic recombination protein SPO11-1
blastp_kegg lcl|fve:101293370 43 348 + 306 Gaps:23 81.92 365 74.25 6e-152 meiotic recombination protein SPO11-1-like
blastp_kegg lcl|mdm:103448311 41 348 + 308 Gaps:23 82.47 365 74.09 6e-150 meiotic recombination protein SPO11-1
blastp_kegg lcl|pxb:103941907 46 348 + 303 Gaps:24 81.15 366 74.75 4e-149 meiotic recombination protein SPO11-1-like
blastp_kegg lcl|pxb:103965437 46 348 + 303 Gaps:24 81.15 366 74.75 4e-149 meiotic recombination protein SPO11-1-like
blastp_kegg lcl|pvu:PHAVU_008G278300g 43 343 + 301 Gaps:29 80.43 373 72.00 2e-146 hypothetical protein
blastp_kegg lcl|vvi:100256655 66 343 + 278 Gaps:22 74.79 361 79.63 2e-146 meiotic recombination protein SPO11-1-like
blastp_kegg lcl|pper:PRUPE_ppa006320mg 46 348 + 303 Gaps:45 83.45 417 65.80 7e-146 hypothetical protein
blastp_pdb 2zbk_G 164 348 + 185 Gaps:12 49.61 389 37.31 6e-32 mol:protein length:389 Type II DNA topoisomerase VI subunit A
blastp_pdb 2zbk_E 164 348 + 185 Gaps:12 49.61 389 37.31 6e-32 mol:protein length:389 Type II DNA topoisomerase VI subunit A
blastp_pdb 2zbk_C 164 348 + 185 Gaps:12 49.61 389 37.31 6e-32 mol:protein length:389 Type II DNA topoisomerase VI subunit A
blastp_pdb 2zbk_A 164 348 + 185 Gaps:12 49.61 389 37.31 6e-32 mol:protein length:389 Type II DNA topoisomerase VI subunit A
blastp_pdb 1d3y_B 60 343 + 284 Gaps:30 93.69 301 29.79 3e-29 mol:protein length:301 DNA TOPOISOMERASE VI A SUBUNIT
blastp_pdb 1d3y_A 60 343 + 284 Gaps:30 93.69 301 29.79 3e-29 mol:protein length:301 DNA TOPOISOMERASE VI A SUBUNIT
blastp_pdb 2q2e_A 44 343 + 300 Gaps:36 80.22 369 25.34 3e-17 mol:protein length:369 Type II DNA topoisomerase VI subunit A
blastp_uniprot_sprot sp|Q9M4A2|SPO11_ARATH 46 346 + 301 Gaps:23 81.22 362 70.07 1e-141 Meiotic recombination protein SPO11-1 OS Arabidopsis thaliana GN SPO11-1 PE 1 SV 1
blastp_uniprot_sprot sp|Q9Y5K1|SPO11_HUMAN 43 345 + 303 Gaps:24 74.49 396 35.93 2e-61 Meiotic recombination protein SPO11 OS Homo sapiens GN SPO11 PE 2 SV 1
blastp_uniprot_sprot sp|Q9LZ03|TOP6A_ARATH 57 343 + 287 Gaps:25 65.11 427 39.21 3e-58 DNA topoisomerase 6 subunit A OS Arabidopsis thaliana GN TOP6A PE 1 SV 1
blastp_uniprot_sprot sp|Q9WTK8|SPO11_MOUSE 57 345 + 289 Gaps:24 70.96 396 35.59 1e-57 Meiotic recombination protein SPO11 OS Mus musculus GN Spo11 PE 2 SV 2
blastp_uniprot_sprot sp|A2XFC1|TOP6A_ORYSI 57 343 + 287 Gaps:25 62.90 442 38.85 4e-54 DNA topoisomerase 6 subunit A OS Oryza sativa subsp. indica GN TOP6A PE 2 SV 2
blastp_uniprot_sprot sp|Q22236|SPO11_CAEEL 50 342 + 293 Gaps:21 66.35 425 34.04 3e-40 Meiotic recombination protein spo-11 OS Caenorhabditis elegans GN spo-11 PE 3 SV 1
blastp_uniprot_sprot sp|Q9YE67|TOP6A_AERPE 64 345 + 282 Gaps:47 76.35 389 32.66 8e-37 Type 2 DNA topoisomerase 6 subunit A OS Aeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1) GN top6A PE 3 SV 2
blastp_uniprot_sprot sp|Q9M4A1|SPO12_ARATH 34 348 + 315 Gaps:41 80.42 383 34.09 3e-36 Meiotic recombination protein SPO11-2 OS Arabidopsis thaliana GN SPO11-2 PE 1 SV 1
blastp_uniprot_sprot sp|A2BLE8|TOP6A_HYPBU 64 345 + 282 Gaps:48 76.49 387 31.76 3e-35 Type 2 DNA topoisomerase 6 subunit A OS Hyperthermus butylicus (strain DSM 5456 / JCM 9403) GN top6A PE 3 SV 1
blastp_uniprot_sprot sp|O05208|TOP6A_SULSH 164 348 + 185 Gaps:12 49.61 389 37.31 2e-31 Type 2 DNA topoisomerase 6 subunit A OS Sulfolobus shibatae GN top6A PE 1 SV 1
rpsblast_cdd gnl|CDD|173774 170 332 + 163 Gaps:3 100.00 160 50.62 2e-54 cd00223 TOPRIM_TopoIIB_SPO TOPRIM_TopoIIB_SPO: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in the type IIB family of DNA topoisomerases and Spo11. This subgroup contains proteins similar to Sulfolobus shibatae topoisomerase VI (TopoVI) and Saccharomyces cerevisiae meiotic recombination factor: Spo11. Type II DNA topoisomerases catalyze the ATP-dependent transport of one DNA duplex through another in the process generating transient double strand breaks via covalent attachments to both DNA strands at the 5' positions. TopoVI enzymes are heterotetramers found in archaea and plants. Spo11 plays a role in generating the double strand breaks that initiate homologous recombination during meiosis. S. shibatae TopoVI relaxes both positive and negative supercoils and in addition has a strong decatenase activity. The TOPRIM domain has two conserved motifs one of which centers at a conserved glutamate and the other one at two conserved aspartates (DxD. For topoisomerases the conserved glutamate is believed to act as a general base in strand joining and as a general acid in strand cleavage. The DXD motif may co-ordinate Mg2+ a cofactor required for full catalytic function.
rpsblast_cdd gnl|CDD|179833 58 345 + 288 Gaps:42 78.47 367 31.25 1e-49 PRK04342 PRK04342 DNA topoisomerase VI subunit A Provisional.
rpsblast_cdd gnl|CDD|31883 47 342 + 296 Gaps:31 81.18 356 35.29 1e-49 COG1697 COG1697 DNA topoisomerase VI subunit A [DNA replication recombination and repair].

16 Domain Motifs

Analysis Begin End Length Domain Identifier Cross Ref Description Inter Pro
Gene3D 136 344 209 G3DSA:3.40.1360.10 none none none
Pfam 57 115 59 PF04406 none Type IIB DNA topoisomerase IPR013049
Gene3D 59 115 57 G3DSA:1.10.10.10 none none IPR011991
SUPERFAMILY 57 344 288 SSF56726 none none IPR002815
PANTHER 54 348 295 PTHR10848:SF3 none none none
PRINTS 91 108 18 PR01550 none DNA topoisomerase VI subunit A family signature IPR002815
PRINTS 196 217 22 PR01550 none DNA topoisomerase VI subunit A family signature IPR002815
PRINTS 172 189 18 PR01550 none DNA topoisomerase VI subunit A family signature IPR002815
PRINTS 228 244 17 PR01550 none DNA topoisomerase VI subunit A family signature IPR002815
PRINTS 77 88 12 PR01550 none DNA topoisomerase VI subunit A family signature IPR002815
PANTHER 54 348 295 PTHR10848 none none IPR002815
PRINTS 186 201 16 PR01551 none SPO11 homologue signature IPR013048
PRINTS 233 252 20 PR01551 none SPO11 homologue signature IPR013048
PRINTS 268 292 25 PR01551 none SPO11 homologue signature IPR013048
PRINTS 83 103 21 PR01551 none SPO11 homologue signature IPR013048
PRINTS 329 348 20 PR01551 none SPO11 homologue signature IPR013048

0 Localization

8 Qtllist

Qtl Name Chromosome Name Linkage Group Prox Marker Dist Marker Position QTL Pos One Pos Two Test Type Test Value R 2
Bourran2_2014_nSecLBD_3P Qrob_Chr08 8 s_1BN2OD_551 s_1B5AYF_599 17,17 0 43,51 lod 1,9229 4,4
Bourran2_2015_nEpiBC_3P Qrob_Chr12 12 s_1B73S5_217 v_7050_211 28,31 26,37 28,45 lod 4.5 11.6
Bourran2_2014_nLBD*_3P Qrob_Chr08 8 v_5216_549 v_11837_70 12,25 0 35,55 lod 2,5951 6
Bourran2_2014_nP*_3P Qrob_Chr08 8 v_5216_549 v_11837_70 12,19 0 31,97 lod 2,8472 6
Bourran2_2014_nPriLBD_3P Qrob_Chr08 8 v_5216_549 v_11837_70 12,36 0 30,43 lod 2,5806 5,1
Champenoux_2015_nSeqBC_A4 Qrob_Chr08 8 v_AD7YD13_501 s_1A7IED_780 43,44 43,42 43,99 lod 3.7 8.9
Bourran2_2014_nEpis*_3P Qrob_Chr08 8 s_1DA4QW_688 s_1DNI7D_820 17,96 0 37,75 lod 2,9745 7,5
Bourran2_2014_nPriBD_3P Qrob_Chr11 11 v_11486_194 s_1AT3E_2335 5,54 0,4 20,6 lod 2,6345 5,9

0 Targeting