Protein : Qrob_P0083060.2 Q. robur
Protein Identifier  ? Qrob_P0083060.2 Organism . Name  Quercus robur
Score  35.1 Score Type  egn
Protein Description  (M=7) K01530 - phospholipid-translocating ATPase [EC:3.6.3.1] Code Enzyme  EC:3.6.3.1
Gene Prediction Quality  validated Protein length 

Sequence

Length: 571  
Kegg Orthology  K01530
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0 Synonyms

6 GO Terms

Identifier Name Description
GO:0005524 ATP binding Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
GO:0016021 integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
GO:0000166 nucleotide binding Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose.
GO:0000287 magnesium ion binding Interacting selectively and non-covalently with magnesium (Mg) ions.
GO:0004012 phospholipid-translocating ATPase activity Catalysis of the movement of phospholipids from one membrane bilayer leaflet to the other, driven by the hydrolysis of ATP.
GO:0015914 phospholipid transport The directed movement of phospholipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Phospholipids are any lipids containing phosphoric acid as a mono- or diester.

38 Blast

Analysis Hit Start End Strand Length Note Hit Coverage Hit Length Hit Pident E Val Hit Description
blastp_kegg lcl|pmum:103328398 5 570 + 566 Gaps:16 52.44 1106 88.10 0.0 phospholipid-transporting ATPase 2
blastp_kegg lcl|pper:PRUPE_ppa016577mg 5 570 + 566 Gaps:16 52.44 1106 88.28 0.0 hypothetical protein
blastp_kegg lcl|rcu:RCOM_1173290 12 570 + 559 Gaps:14 79.86 715 89.84 0.0 phospholipid-transporting atpase putative (EC:3.6.3.1)
blastp_kegg lcl|mdm:103405644 5 570 + 566 Gaps:16 52.44 1106 87.76 0.0 phospholipid-transporting ATPase 2
blastp_kegg lcl|cit:102610232 14 570 + 557 Gaps:13 51.45 1104 88.56 0.0 phospholipid-transporting ATPase 2-like
blastp_kegg lcl|fve:101292415 5 570 + 566 Gaps:16 52.44 1106 86.90 0.0 phospholipid-transporting ATPase 2-like
blastp_kegg lcl|tcc:TCM_008159 14 570 + 557 Gaps:14 50.22 1133 90.51 0.0 Aminophospholipid ATPase isoform 1
blastp_kegg lcl|cam:101488672 14 570 + 557 Gaps:13 51.40 1105 87.15 0.0 phospholipid-transporting ATPase 2-like
blastp_kegg lcl|cic:CICLE_v100140951m 14 570 + 557 Gaps:16 60.49 944 87.92 0.0 hypothetical protein
blastp_kegg lcl|pop:POPTR_0017s04520g 12 570 + 559 Gaps:12 51.58 1107 87.74 0.0 hypothetical protein
blastp_pdb 3a3y_A 78 259 + 182 Gaps:20 16.15 1028 34.34 3e-07 mol:protein length:1028 Na K-ATPase alpha subunit
blastp_pdb 2zxe_A 78 259 + 182 Gaps:20 16.15 1028 34.34 3e-07 mol:protein length:1028 Na K-ATPase alpha subunit
blastp_pdb 3ixz_A 79 259 + 181 Gaps:28 15.96 1034 33.33 2e-06 mol:protein length:1034 Potassium-transporting ATPase alpha
blastp_pdb 2xzb_A 79 259 + 181 Gaps:28 15.96 1034 33.33 2e-06 mol:protein length:1034 POTASSIUM-TRANSPORTING ATPASE ALPHA CHAIN 1
blastp_uniprot_sprot sp|P98205|ALA2_ARATH 14 570 + 557 Gaps:16 51.58 1107 84.06 0.0 Phospholipid-transporting ATPase 2 OS Arabidopsis thaliana GN ALA2 PE 1 SV 1
blastp_uniprot_sprot sp|O94296|YOOC_SCHPO 24 493 + 470 Gaps:31 39.51 1258 36.62 1e-86 Probable phospholipid-transporting ATPase C887.12 OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN SPBC887.12 PE 3 SV 1
blastp_uniprot_sprot sp|P39524|ATC3_YEAST 8 493 + 486 Gaps:44 37.93 1355 35.41 1e-86 Probable phospholipid-transporting ATPase DRS2 OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN DRS2 PE 1 SV 2
blastp_uniprot_sprot sp|P98204|ALA1_ARATH 24 495 + 472 Gaps:33 41.71 1158 36.02 1e-82 Phospholipid-transporting ATPase 1 OS Arabidopsis thaliana GN ALA1 PE 1 SV 1
blastp_uniprot_sprot sp|Q9LNQ4|ALA4_ARATH 24 490 + 467 Gaps:43 41.28 1216 33.47 6e-82 Putative phospholipid-transporting ATPase 4 OS Arabidopsis thaliana GN ALA4 PE 1 SV 2
blastp_uniprot_sprot sp|Q9SGG3|ALA5_ARATH 26 498 + 473 Gaps:44 41.45 1228 34.58 3e-81 Putative phospholipid-transporting ATPase 5 OS Arabidopsis thaliana GN ALA5 PE 3 SV 1
blastp_uniprot_sprot sp|Q9Y2G3|AT11B_HUMAN 8 496 + 489 Gaps:35 43.33 1177 35.69 5e-81 Probable phospholipid-transporting ATPase IF OS Homo sapiens GN ATP11B PE 1 SV 2
blastp_uniprot_sprot sp|Q9LK90|ALA8_ARATH 8 493 + 486 Gaps:50 44.91 1189 32.58 1e-80 Putative phospholipid-transporting ATPase 8 OS Arabidopsis thaliana GN ALA8 PE 3 SV 1
blastp_uniprot_sprot sp|Q9LVK9|ALA7_ARATH 6 494 + 489 Gaps:46 42.56 1243 32.70 1e-80 Putative phospholipid-transporting ATPase 7 OS Arabidopsis thaliana GN ALA7 PE 3 SV 3
blastp_uniprot_sprot sp|Q9SAF5|ALA11_ARATH 15 489 + 475 Gaps:48 42.98 1203 34.43 3e-80 Putative phospholipid-transporting ATPase 11 OS Arabidopsis thaliana GN ALA11 PE 2 SV 1
rpsblast_cdd gnl|CDD|200120 22 490 + 469 Gaps:34 46.83 1057 38.38 1e-121 TIGR01652 ATPase-Plipid phospholipid-translocating P-type ATPase flippase. This model describes the P-type ATPase responsible for transporting phospholipids from one leaflet of bilayer membranes to the other. These ATPases are found only in eukaryotes.
rpsblast_cdd gnl|CDD|178732 1 513 + 513 Gaps:50 45.08 1178 35.22 2e-86 PLN03190 PLN03190 aminophospholipid translocase Provisional.
rpsblast_cdd gnl|CDD|30822 20 489 + 470 Gaps:84 44.49 917 25.98 2e-54 COG0474 MgtA Cation transport ATPase [Inorganic ion transport and metabolism].
rpsblast_cdd gnl|CDD|162469 20 255 + 236 Gaps:35 22.11 1054 27.90 6e-20 TIGR01657 P-ATPase-V P-type ATPase of unknown pump specificity (type V). These P-type ATPases form a distinct clade but the substrate of their pumping activity has yet to be determined. This clade has been designated type V in.
rpsblast_cdd gnl|CDD|211660 20 311 + 292 Gaps:48 35.42 528 35.29 7e-16 TIGR01494 ATPase_P-type ATPase P-type (transporting) HAD superfamily subfamily IC. The P-type ATPases are a large family of trans-membrane transporters acting on charged substances. The distinguishing feature of the family is the formation of a phosphorylated intermediate (aspartyl-phosphate) during the course of the reaction. Another common name for these enzymes is the E1-E2 ATPases based on the two isolable conformations: E1 (unphosphorylated) and E2 (phosphorylated). Generally P-type ATPases consist of only a single subunit encompassing the ATPase and ion translocation pathway however in the case of the potassium (TIGR01497) and sodium/potassium (TIGR01106) varieties these functions are split between two subunits. Additional small regulatory or stabilizing subunits may also exist in some forms. P-type ATPases are nearly ubiquitous in life and are found in numerous copies in higher organisms (at least 45 in Arabidopsis thaliana for instance). Phylogenetic analyses have revealed that the P-type ATPase subfamily is divided up into groups based on substrate specificities and this is represented in the various subfamily and equivalog models that have been made: IA (K+) TIGR01497 IB (heavy metals) TIGR01525 IIA1 (SERCA-type Ca++) TIGR01116 IIA2 (PMR1-type Ca++) TIGR01522 IIB (PMCA-type Ca++) TIGR01517 IIC (Na+/K+ H+/K+ antiporters) TIGR01106 IID (fungal-type Na+ and K+) TIGR01523 IIIA (H+) TIGR01647 IIIB (Mg++) TIGR01524 IV (phospholipid flippase) TIGR01652 and V (unknown specificity) TIGR01657. The crystal structure of one calcium-pumping ATPase and an analysis of the fold of the catalytic domain of the P-type ATPases have been published. These reveal that the catalytic core of these enzymes is a haloacid dehalogenase(HAD)-type aspartate-nucleophile hydrolase. The location of the ATP-binding loop in between the first and second HAD conserved catalytic motifs defines these enzymes as members of subfamily I of the HAD superfamily (see also TIGR01493 TIGR01509 TIGR01549 TIGR01544 and TIGR01545). Based on these classifications the P-type ATPase _superfamily_ corresponds to the IC subfamily of the HAD superfamily.
rpsblast_cdd gnl|CDD|188151 22 374 + 353 Gaps:102 31.04 944 30.72 8e-13 TIGR01517 ATPase-IIB_Ca plasma-membrane calcium-translocating P-type ATPase. This model describes the P-type ATPase responsible for translocating calcium ions across the plasma membrane of eukaryotes out of the cell. In some organisms this type of pump may also be found in vacuolar membranes. In humans and mice at least there are multiple isoforms of the PMCA pump with overlapping but not redundant functions. Accordingly there are no human diseases linked to PMCA defects although alterations of PMCA function do elicit physiological effects. The calcium P-type ATPases have been characterized as Type IIB based on a phylogenetic analysis which distinguishes this group from the Type IIA SERCA calcium pump. A separate analysis divides Type IIA into sub-types (SERCA and PMR1) which are modelled by two corresponding families (TIGR01116 and TIGR01522). This model is well separated from those.

25 Domain Motifs

Analysis Begin End Length Domain Identifier Cross Ref Description Inter Pro
Phobius 435 454 20 CYTOPLASMIC_DOMAIN none Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm. none
Phobius 317 359 43 NON_CYTOPLASMIC_DOMAIN none Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region. none
Pfam 63 241 179 PF00702 none haloacid dehalogenase-like hydrolase IPR023214
Phobius 477 570 94 NON_CYTOPLASMIC_DOMAIN none Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region. none
Phobius 388 407 20 TRANSMEMBRANE none Region of a membrane-bound protein predicted to be embedded in the membrane. none
Phobius 382 387 6 CYTOPLASMIC_DOMAIN none Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm. none
Phobius 360 381 22 TRANSMEMBRANE none Region of a membrane-bound protein predicted to be embedded in the membrane. none
Phobius 1 294 294 CYTOPLASMIC_DOMAIN none Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm. none
Gene3D 84 149 66 G3DSA:3.40.50.1000 none none IPR023214
Gene3D 188 267 80 G3DSA:3.40.50.1000 none none IPR023214
Phobius 295 316 22 TRANSMEMBRANE none Region of a membrane-bound protein predicted to be embedded in the membrane. none
TIGRFAM 17 489 473 TIGR01652 none ATPase-Plipid: phospholipid-translocating P-type ATPase, flippase IPR006539
Phobius 408 412 5 NON_CYTOPLASMIC_DOMAIN none Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region. none
Phobius 455 476 22 TRANSMEMBRANE none Region of a membrane-bound protein predicted to be embedded in the membrane. none
SUPERFAMILY 276 482 207 SSF81665 none none none
Phobius 413 434 22 TRANSMEMBRANE none Region of a membrane-bound protein predicted to be embedded in the membrane. none
TIGRFAM 77 136 60 TIGR01494 none ATPase_P-type: HAD ATPase, P-type, family IC IPR001757
TIGRFAM 193 323 131 TIGR01494 none ATPase_P-type: HAD ATPase, P-type, family IC IPR001757
SUPERFAMILY 75 138 64 SSF56784 none none IPR023214
SUPERFAMILY 172 275 104 SSF56784 none none IPR023214
PRINTS 227 246 20 PR00119 none P-type cation-transporting ATPase superfamily signature IPR001757
PRINTS 105 115 11 PR00119 none P-type cation-transporting ATPase superfamily signature IPR001757
PANTHER 8 493 486 PTHR24092:SF19 none none none
PANTHER 8 493 486 PTHR24092 none none IPR006539
Gene3D 15 83 69 G3DSA:3.40.1110.10 none none IPR023299

4 Localization

Analysis Start End Length
TMHMM 454 476 22
TMHMM 359 381 22
TMHMM 412 434 22
TMHMM 295 317 22

16 Qtllist

Qtl Name Chromosome Name Linkage Group Prox Marker Dist Marker Position QTL Pos One Pos Two Test Type Test Value R 2
Bourran2_2014_nLBD*_A4 Qrob_Chr08 8 v_12498_318 v_12364_308 34,91 16,12 53,62 lod 2,4961 5,2
Bourran2_2014_nSecLBD_3P Qrob_Chr08 8 s_1BN2OD_551 s_1B5AYF_599 17,17 0 43,51 lod 1,9229 4,4
Bourran2_2014_rEpiBC*_A4 Qrob_Chr08 8 v_12498_318 v_12364_308 35,77 14,11 55,31 lod 2,9413 6,2
Bourran2_2015_nEpiBC_3P Qrob_Chr12 12 s_1B73S5_217 v_7050_211 28,31 26,37 28,45 lod 4.5 11.6
Bourran_2000_2002_QTL3_Delta.F Qrob_Chr08 8 s_1A3EF7_1406 s_1AIWYC_607 30.17 21,01 40,21 lod 6.8553 0.055
Bourran2_2014_aSeqBC_A4 Qrob_Chr08 8 v_15999_278 v_AP13YL15_395 32,52 4,22 57,22 lod 2,7561 6,7
Bourran2_2014_nFork*_A4 Qrob_Chr08 8 PIE175 s_1CD7GJ_1398 31,22 5,24 57,24 lod 2,6724 6,8
Bourran2_2014_nLBD*_3P Qrob_Chr08 8 v_5216_549 v_11837_70 12,25 0 35,55 lod 2,5951 6
Bourran2_2014_nP*_3P Qrob_Chr08 8 v_5216_549 v_11837_70 12,19 0 31,97 lod 2,8472 6
Bourran2_2014_nPriLBD_3P Qrob_Chr08 8 v_5216_549 v_11837_70 12,36 0 30,43 lod 2,5806 5,1
Bourran2_2014_nPriLBD_A4 Qrob_Chr08 8 PIE175 v_9164_159 31,85 15,39 48,29 lod 2,8308 6,8
Bourran2_2015_rEpiBC_3P Qrob_Chr08 8 s_A9TNV_543 v_11837_70 9,93 9,83 11,15 lod 3.3 7.3
Champenoux_2015_nSeqBC_A4 Qrob_Chr08 8 v_AD7YD13_501 s_1A7IED_780 43,44 43,42 43,99 lod 3.7 8.9
NancyGreenhouseCO2_2001_ambient_elevated_leaf_cellulose_QTL3_d13Cf Qrob_Chr08 8 v_5216_549 v_11625_20 37.08 12,26 54,9 lod 6.5888 0.04
Bourran2_2014_nEpis*_3P Qrob_Chr08 8 s_1DA4QW_688 s_1DNI7D_820 17,96 0 37,75 lod 2,9745 7,5
Bourran2_2014_nPriBD_3P Qrob_Chr11 11 v_11486_194 s_1AT3E_2335 5,54 0,4 20,6 lod 2,6345 5,9

0 Targeting