| Analysis | rpsblast_cdd | Start | 20 |
| End | 311 | Strand | + |
| Length | 292 | Note | Gaps:48 |
| Hit Coverage | 35.42 | Hit Length | 528 |
| Hit Pident | 35.29 | E Val | 7e-16 |
| Hit Description | TIGR01494 ATPase_P-type ATPase P-type (transporting) HAD superfamily subfamily IC. The P-type ATPases are a large family of trans-membrane transporters acting on charged substances. The distinguishing feature of the family is the formation of a phosphorylated intermediate (aspartyl-phosphate) during the course of the reaction. Another common name for these enzymes is the E1-E2 ATPases based on the two isolable conformations: E1 (unphosphorylated) and E2 (phosphorylated). Generally P-type ATPases consist of only a single subunit encompassing the ATPase and ion translocation pathway however in the case of the potassium (TIGR01497) and sodium/potassium (TIGR01106) varieties these functions are split between two subunits. Additional small regulatory or stabilizing subunits may also exist in some forms. P-type ATPases are nearly ubiquitous in life and are found in numerous copies in higher organisms (at least 45 in Arabidopsis thaliana for instance). Phylogenetic analyses have revealed that the P-type ATPase subfamily is divided up into groups based on substrate specificities and this is represented in the various subfamily and equivalog models that have been made: IA (K+) TIGR01497 IB (heavy metals) TIGR01525 IIA1 (SERCA-type Ca++) TIGR01116 IIA2 (PMR1-type Ca++) TIGR01522 IIB (PMCA-type Ca++) TIGR01517 IIC (Na+/K+ H+/K+ antiporters) TIGR01106 IID (fungal-type Na+ and K+) TIGR01523 IIIA (H+) TIGR01647 IIIB (Mg++) TIGR01524 IV (phospholipid flippase) TIGR01652 and V (unknown specificity) TIGR01657. The crystal structure of one calcium-pumping ATPase and an analysis of the fold of the catalytic domain of the P-type ATPases have been published. These reveal that the catalytic core of these enzymes is a haloacid dehalogenase(HAD)-type aspartate-nucleophile hydrolase. The location of the ATP-binding loop in between the first and second HAD conserved catalytic motifs defines these enzymes as members of subfamily I of the HAD superfamily (see also TIGR01493 TIGR01509 TIGR01549 TIGR01544 and TIGR01545). Based on these classifications the P-type ATPase _superfamily_ corresponds to the IC subfamily of the HAD superfamily. | Hit Pcons | 12.83 |
| Name | Qrob_P0083060.2 |
| Protein Identifier |
Organism . Name |
Score | Score Type | Protein Description | Alias (in v1) | Code Enzyme | Gene Prediction Quality |
|---|---|---|---|---|---|---|---|
| Qrob_P0083060.2 | Quercus robur | 35.1 | egn | (M=7) K01530 - phospholipid-translocating ATPase [EC:3.6.3.1] | EC:3.6.3.1 | validated |
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