Protein : Qrob_P0019160.2 Q. robur
Protein Identifier  ? Qrob_P0019160.2 Organism . Name  Quercus robur
Score  100.1 Score Type  egn
Protein Description  (M=7) PTHR10110:SF101 - SODIUM/HYDROGEN EXCHANGER 4 (PTHR10110:SF101) Gene Prediction Quality  validated
Protein length 

Sequence

Length: 541  
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0 Synonyms

11 GO Terms

Identifier Name Description
GO:0055085 transmembrane transport The process in which a solute is transported from one side of a membrane to the other.
GO:0016021 integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
GO:0006814 sodium ion transport The directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
GO:0015299 solute:proton antiporter activity Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + H+(in) = solute(in) + H+(out).
GO:0006885 regulation of pH Any process involved in the maintenance of an internal equilibrium of hydrogen ions, thereby modulating the internal pH, within an organism or cell.
GO:0015385 sodium:proton antiporter activity Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + H+(in) = Na+(in) + H+(out).
GO:0005774 vacuolar membrane The lipid bilayer surrounding the vacuole and separating its contents from the cytoplasm of the cell.
GO:0005886 plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
GO:0009651 response to salt stress Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of salt (particularly but not exclusively sodium and chloride ions) in the environment.
GO:0055075 potassium ion homeostasis Any process involved in the maintenance of an internal steady state of potassium ions within an organism or cell.

29 Blast

Analysis Hit Start End Strand Length Note Hit Coverage Hit Length Hit Pident E Val Hit Description
blastp_kegg lcl|mdm:103449111 10 534 + 525 Gaps:4 96.33 545 78.67 0.0 sodium/hydrogen exchanger 2-like
blastp_kegg lcl|tcc:TCM_021126 5 537 + 533 Gaps:5 98.34 543 79.03 0.0 Sodium/hydrogen exchanger
blastp_kegg lcl|fve:101293187 14 537 + 524 Gaps:3 96.49 542 76.86 0.0 sodium/hydrogen exchanger 2-like
blastp_kegg lcl|pxb:103967376 7 534 + 528 Gaps:5 96.70 545 77.61 0.0 sodium/hydrogen exchanger 2-like
blastp_kegg lcl|pmum:103333862 1 540 + 540 Gaps:8 98.00 551 77.04 0.0 sodium/hydrogen exchanger 2-like
blastp_kegg lcl|pper:PRUPE_ppa003745mg 18 534 + 517 Gaps:12 95.28 551 76.38 0.0 hypothetical protein
blastp_kegg lcl|vvi:100261462 15 534 + 520 Gaps:5 96.47 538 78.61 0.0 sodium/hydrogen exchanger 2-like
blastp_kegg lcl|pper:PRUPE_ppa027158mg 1 540 + 540 Gaps:8 98.00 551 76.48 0.0 hypothetical protein
blastp_kegg lcl|tcc:TCM_004534 16 534 + 519 Gaps:4 98.66 524 76.79 0.0 Sodium/hydrogen exchanger isoform 1
blastp_kegg lcl|mdm:103408100 7 534 + 528 Gaps:5 96.70 545 77.04 0.0 sodium/hydrogen exchanger 2-like
blastp_uniprot_sprot sp|Q56XP4|NHX2_ARATH 12 534 + 523 Gaps:7 96.34 546 73.00 0.0 Sodium/hydrogen exchanger 2 OS Arabidopsis thaliana GN NHX2 PE 2 SV 2
blastp_uniprot_sprot sp|Q68KI4|NHX1_ARATH 14 534 + 521 Gaps:5 96.28 538 72.39 0.0 Sodium/hydrogen exchanger 1 OS Arabidopsis thaliana GN NHX1 PE 1 SV 2
blastp_uniprot_sprot sp|Q84WG1|NHX3_ARATH 16 504 + 489 Gaps:16 96.82 503 72.07 0.0 Sodium/hydrogen exchanger 3 OS Arabidopsis thaliana GN NHX3 PE 2 SV 2
blastp_uniprot_sprot sp|Q8S397|NHX4_ARATH 1 521 + 521 Gaps:19 98.30 529 58.65 0.0 Sodium/hydrogen exchanger 4 OS Arabidopsis thaliana GN NHX4 PE 2 SV 2
blastp_uniprot_sprot sp|Q8R4D1|SL9A8_MOUSE 13 465 + 453 Gaps:38 77.60 576 34.45 4e-60 Sodium/hydrogen exchanger 8 OS Mus musculus GN Slc9a8 PE 2 SV 1
blastp_uniprot_sprot sp|Q4L208|SL9A8_RAT 13 465 + 453 Gaps:38 77.74 575 34.45 4e-60 Sodium/hydrogen exchanger 8 OS Rattus norvegicus GN Slc9a8 PE 2 SV 1
blastp_uniprot_sprot sp|Q5ZJ75|SL9A8_CHICK 13 465 + 453 Gaps:32 77.87 574 34.45 5e-60 Sodium/hydrogen exchanger 8 OS Gallus gallus PE 2 SV 1
blastp_uniprot_sprot sp|Q9Y2E8|SL9A8_HUMAN 13 465 + 453 Gaps:40 76.94 581 34.90 4e-59 Sodium/hydrogen exchanger 8 OS Homo sapiens GN SLC9A8 PE 1 SV 4
blastp_uniprot_sprot sp|Q552S0|NHE1_DICDI 18 534 + 517 Gaps:66 68.99 674 34.41 1e-53 Sodium/hydrogen exchanger 1 OS Dictyostelium discoideum GN nhe1 PE 2 SV 1
blastp_uniprot_sprot sp|Q8RWU6|NHX6_ARATH 25 435 + 411 Gaps:38 75.33 535 35.73 7e-50 Sodium/hydrogen exchanger 6 OS Arabidopsis thaliana GN NHX6 PE 1 SV 3
rpsblast_cdd gnl|CDD|162063 25 445 + 421 Gaps:38 72.45 559 34.32 5e-56 TIGR00840 b_cpa1 sodium/hydrogen exchanger 3. The Monovalent Cation:Proton Antiporter-1 (CPA1) Family (TC 2.A.36)The CPA1 family is a large family of proteins derived from Gram-positive and Gram-negative bacteria blue green bacteria yeast plants and animals.Transporters from eukaryotes have been functionally characterized and all of these catalyze Na+:H+ exchange. Their primary physiological functions may be in(1) cytoplasmic pH regulation extruding the H+ generated during metabolism and (2) salt tolerance (in plants) due to Na+ uptake into vacuoles.This Hmm is specific for the eukaryotic members members of this family.
rpsblast_cdd gnl|CDD|30375 25 445 + 421 Gaps:29 92.77 429 23.87 1e-33 COG0025 NhaP NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism].
rpsblast_cdd gnl|CDD|201544 28 439 + 412 Gaps:46 100.00 370 28.11 6e-31 pfam00999 Na_H_Exchanger Sodium/hydrogen exchanger family. Na/H antiporters are key transporters in maintaining the pH of actively metabolising cells. The molecular mechanisms of antiport are unclear. These antiporters contain 10-12 transmembrane regions (M) at the amino-terminus and a large cytoplasmic region at the carboxyl terminus. The transmembrane regions M3-M12 share identity with other members of the family. The M6 and M7 regions are highly conserved. Thus this is thought to be the region that is involved in the transport of sodium and hydrogen ions. The cytoplasmic region has little similarity throughout the family.
rpsblast_cdd gnl|CDD|129911 79 443 + 365 Gaps:39 68.57 525 23.89 1e-21 TIGR00831 a_cpa1 Na+/H+ antiporter bacterial form. The Monovalent Cation:Proton Antiporter-1 (CPA1) Family (TC 2.A.36) The CPA1 family is a large family of proteins derived from Gram-positive and Gram-negative bacteria blue green bacteria yeast plants and animals. Transporters from eukaryotes have been functionally characterized and all of these catalyze Na+:H+ exchange. Their primary physiological functions may be in (1) cytoplasmic pH regulation extruding the H+ generated during metabolism and (2) salt tolerance (in plants) due to Na+ uptake into vacuoles. This Hmm is specific for the bacterial members of this family.
rpsblast_cdd gnl|CDD|33074 22 445 + 424 Gaps:49 67.42 574 23.26 5e-11 COG3263 COG3263 NhaP-type Na+/H+ and K+/H+ antiporters with a unique C-terminal domain [Inorganic ion transport and metabolism].
rpsblast_cdd gnl|CDD|30823 18 452 + 435 Gaps:53 99.24 397 19.29 3e-07 COG0475 KefB Kef-type K+ transport systems membrane components [Inorganic ion transport and metabolism].
rpsblast_cdd gnl|CDD|180017 118 401 + 284 Gaps:61 45.37 562 27.45 6e-07 PRK05326 PRK05326 potassium/proton antiporter Reviewed.
rpsblast_kog gnl|CDD|37176 21 534 + 514 Gaps:37 92.00 575 45.56 1e-136 KOG1965 KOG1965 KOG1965 Sodium/hydrogen exchanger protein [Inorganic ion transport and metabolism].
rpsblast_kog gnl|CDD|37177 25 445 + 421 Gaps:41 60.30 670 32.92 6e-51 KOG1966 KOG1966 KOG1966 Sodium/hydrogen exchanger protein [Inorganic ion transport and metabolism].

31 Domain Motifs

Analysis Begin End Length Domain Identifier Cross Ref Description Inter Pro
TIGRFAM 24 450 427 TIGR00840 "Reactome:REACT_15518" b_cpa1: sodium/hydrogen exchanger 3 IPR004709
Phobius 240 258 19 NON_CYTOPLASMIC_DOMAIN none Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region. none
Phobius 1 19 19 NON_CYTOPLASMIC_DOMAIN none Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region. none
Phobius 417 437 21 TRANSMEMBRANE none Region of a membrane-bound protein predicted to be embedded in the membrane. none
Phobius 323 341 19 NON_CYTOPLASMIC_DOMAIN none Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region. none
Phobius 438 540 103 CYTOPLASMIC_DOMAIN none Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm. none
Phobius 342 365 24 TRANSMEMBRANE none Region of a membrane-bound protein predicted to be embedded in the membrane. none
PRINTS 152 162 11 PR01084 "Reactome:REACT_15518" Na+/H+ exchanger signature IPR004709
PRINTS 97 111 15 PR01084 "Reactome:REACT_15518" Na+/H+ exchanger signature IPR004709
PRINTS 112 120 9 PR01084 "Reactome:REACT_15518" Na+/H+ exchanger signature IPR004709
PRINTS 83 94 12 PR01084 "Reactome:REACT_15518" Na+/H+ exchanger signature IPR004709
Phobius 136 173 38 NON_CYTOPLASMIC_DOMAIN none Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region. none
Phobius 386 405 20 TRANSMEMBRANE none Region of a membrane-bound protein predicted to be embedded in the membrane. none
Phobius 72 82 11 NON_CYTOPLASMIC_DOMAIN none Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region. none
Pfam 28 443 416 PF00999 none Sodium/hydrogen exchanger family IPR006153
PANTHER 1 522 522 PTHR10110 "Reactome:REACT_15518";signature_desc=SODIUM/HYDROGEN EXCHANGER none IPR018422
Phobius 198 216 19 CYTOPLASMIC_DOMAIN none Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm. none
Phobius 101 111 11 CYTOPLASMIC_DOMAIN none Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm. none
Phobius 217 239 23 TRANSMEMBRANE none Region of a membrane-bound protein predicted to be embedded in the membrane. none
Phobius 259 284 26 TRANSMEMBRANE none Region of a membrane-bound protein predicted to be embedded in the membrane. none
Phobius 305 322 18 TRANSMEMBRANE none Region of a membrane-bound protein predicted to be embedded in the membrane. none
Phobius 20 42 23 TRANSMEMBRANE none Region of a membrane-bound protein predicted to be embedded in the membrane. none
Phobius 43 53 11 CYTOPLASMIC_DOMAIN none Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm. none
Phobius 366 385 20 CYTOPLASMIC_DOMAIN none Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm. none
Phobius 112 135 24 TRANSMEMBRANE none Region of a membrane-bound protein predicted to be embedded in the membrane. none
Phobius 54 71 18 TRANSMEMBRANE none Region of a membrane-bound protein predicted to be embedded in the membrane. none
Phobius 83 100 18 TRANSMEMBRANE none Region of a membrane-bound protein predicted to be embedded in the membrane. none
Phobius 285 304 20 CYTOPLASMIC_DOMAIN none Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm. none
Phobius 406 416 11 NON_CYTOPLASMIC_DOMAIN none Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region. none
PANTHER 1 522 522 PTHR10110:SF101 none none IPR029872

11 Localization

Analysis Start End Length
TMHMM 303 325 22
TMHMM 269 291 22
TMHMM 20 42 22
TMHMM 76 98 22
TMHMM 217 239 22
TMHMM 105 127 22
TMHMM 383 405 22
TMHMM 340 362 22
TMHMM 415 437 22
TMHMM 174 196 22
TMHMM 47 66 19

0 Qtllist

1 Targeting

Analysis Start End Length Location Reliability Signal Peptide Cut Off Mitochondrion Cut Off Network Signal Peptide Length
TargetP 1 39   Secretory pathway 3 0.750 0.109 NON-PLANT 39