Protein : Qrob_P0005700.2 Q. robur
Protein Identifier  ? Qrob_P0005700.2 Organism . Name  Quercus robur
Score  18.0 Score Type  egn
Protein Description  (M=1) KOG0889//KOG0890//KOG0891//KOG0892//KOG0903//KOG0904//KOG0905//KOG0906 - Histone acetyltransferase SAGA TRRAP/TRA1 component PI-3 kinase superfamily [Signal transduction mechanisms Chromatin structure and dynamics Replication recombination and repair Cell cycle control cell division chromosome partitioning]. // Protein kinase of the PI-3 kinase family involved in mitotic growth DNA repair and meiotic recombination [Signal transduction mechanisms Chromatin structure and dynamics Replication recombination and repair Cell cycle control cell division chromosome partitioning]. // DNA-dependent protein kinase [Replication recombination and repair]. // Protein kinase ATM/Tel1 involved in telomere length regulation and DNA repair [Signal transduction mechanisms Chromatin structure and dynamics Replication recombination and repair Cell cycle control cell division chromosome partitioning]. // Phosphatidylinositol 4-kinase involved in intracellular trafficking and secretion [Signal transduction mechanisms Intracellular trafficking secretion and vesicular transport]. // Phosphatidylinositol 3-kinase catalytic subunit (p110) [Signal transduction mechanisms]. // Phosphoinositide 3-kinase [Signal transduction mechanisms]. // Phosphatidylinositol 3-kinase VPS34 involved in signal transduction [Signal transduction mechanisms Intracellular trafficking secretion and vesicular transport]. Code Enzyme  EC:2.7.11.1
Gene Prediction Quality  validated Protein length 

Sequence

Length: 762  
Kegg Orthology  K04728
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0 Synonyms

2 GO Terms

Identifier Name Description
GO:0005515 protein binding Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
GO:0016773 phosphotransferase activity, alcohol group as acceptor Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to an alcohol group (acceptor).

44 Blast

Analysis Hit Start End Strand Length Note Hit Coverage Hit Length Hit Pident E Val Hit Description
blastp_kegg lcl|vvi:100250198 5 761 + 757 Gaps:30 24.59 2956 88.86 0.0 serine/threonine-protein kinase ATM-like
blastp_kegg lcl|mdm:103438130 5 761 + 757 Gaps:30 80.96 898 87.21 0.0 serine/threonine-protein kinase ATM-like
blastp_kegg lcl|cic:CICLE_v10018427mg 5 761 + 757 Gaps:30 24.83 2928 86.93 0.0 hypothetical protein
blastp_kegg lcl|cit:102620162 5 761 + 757 Gaps:30 24.00 3029 86.93 0.0 serine/threonine-protein kinase ATM-like
blastp_kegg lcl|pper:PRUPE_ppa000124mg 5 761 + 757 Gaps:30 42.22 1722 86.80 0.0 hypothetical protein
blastp_kegg lcl|rcu:RCOM_1510550 4 761 + 758 Gaps:30 24.64 2954 86.54 0.0 ataxia telangiectasia mutated putative (EC:2.7.11.1)
blastp_kegg lcl|gmx:100788458 5 761 + 757 Gaps:30 23.97 3033 85.14 0.0 serine/threonine-protein kinase ATM-like
blastp_kegg lcl|cam:101498080 5 761 + 757 Gaps:30 24.61 2954 85.14 0.0 serine/threonine-protein kinase ATM-like
blastp_kegg lcl|csv:101208785 8 761 + 754 Gaps:30 24.25 2985 85.91 0.0 serine/threonine-protein kinase ATM-like
blastp_kegg lcl|fve:101295891 5 761 + 757 Gaps:41 23.34 3068 86.45 0.0 serine/threonine-protein kinase ATM-like
blastp_pdb 2y3a_A 568 723 + 156 Gaps:26 13.37 1092 36.99 1e-10 mol:protein length:1092 PHOSPHATIDYLINOSITOL-4 5-BISPHOSPHATE 3-KINAS
blastp_pdb 1e90_A 439 669 + 231 Gaps:45 20.81 961 27.00 6e-07 mol:protein length:961 PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUN
blastp_pdb 1e8x_A 439 669 + 231 Gaps:45 20.81 961 27.00 6e-07 mol:protein length:961 PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUN
blastp_pdb 1e8w_A 439 669 + 231 Gaps:45 20.81 961 27.00 6e-07 mol:protein length:961 PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUN
blastp_pdb 1e7v_A 439 669 + 231 Gaps:45 20.81 961 27.00 6e-07 mol:protein length:961 PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUN
blastp_pdb 1e7u_A 439 669 + 231 Gaps:45 20.81 961 27.00 6e-07 mol:protein length:961 PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUN
blastp_uniprot_sprot sp|Q9M3G7|ATM_ARATH 7 761 + 755 Gaps:31 18.83 3856 80.17 0.0 Serine/threonine-protein kinase ATM OS Arabidopsis thaliana GN ATM PE 2 SV 1
blastp_uniprot_sprot sp|Q13315|ATM_HUMAN 5 761 + 757 Gaps:112 24.64 3056 42.76 9e-170 Serine-protein kinase ATM OS Homo sapiens GN ATM PE 1 SV 4
blastp_uniprot_sprot sp|Q62388|ATM_MOUSE 27 761 + 735 Gaps:80 23.52 3066 43.13 5e-169 Serine-protein kinase ATM OS Mus musculus GN Atm PE 1 SV 2
blastp_uniprot_sprot sp|Q6PQD5|ATM_PIG 5 761 + 757 Gaps:112 24.63 3057 42.10 1e-165 Serine-protein kinase ATM OS Sus scrofa GN ATM PE 3 SV 2
blastp_uniprot_sprot sp|Q4WVM7|ATM_ASPFU 33 760 + 728 Gaps:84 24.32 2796 38.53 6e-121 Serine/threonine-protein kinase tel1 OS Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) GN tel1 PE 3 SV 2
blastp_uniprot_sprot sp|Q7RZT9|ATM_NEUCR 144 760 + 617 Gaps:55 20.89 2939 38.60 5e-119 Serine/threonine-protein kinase tel1 OS Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) GN mus-21 PE 3 SV 2
blastp_uniprot_sprot sp|Q5EAK6|ATM_DROME 156 761 + 606 Gaps:48 21.25 2767 39.29 2e-117 Serine/threonine-protein kinase ATM OS Drosophila melanogaster GN tefu PE 2 SV 1
blastp_uniprot_sprot sp|O74630|ATM_SCHPO 176 760 + 585 Gaps:56 20.66 2812 38.55 1e-116 Serine/threonine-protein kinase tel1 OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN tel1 PE 1 SV 1
blastp_uniprot_sprot sp|Q4IB89|ATM_GIBZE 144 760 + 617 Gaps:64 21.79 2813 38.83 2e-116 Serine/threonine-protein kinase TEL1 OS Gibberella zeae (strain PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084) GN TEL1 PE 3 SV 1
blastp_uniprot_sprot sp|Q2U639|ATM_ASPOR 176 760 + 585 Gaps:49 19.62 2925 40.07 5e-116 Serine/threonine-protein kinase tel1 OS Aspergillus oryzae (strain ATCC 42149 / RIB 40) GN tel1 PE 3 SV 1
rpsblast_cdd gnl|CDD|119431 401 678 + 278 Gaps:9 100.00 279 63.80 1e-143 cd05171 PIKKc_ATM Ataxia telangiectasia mutated (ATM) catalytic domain The ATM catalytic domain subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as the typical serine/threonine/tyrosine protein kinases (PKs) aminoglycoside phosphotransferase choline kinase and RIO kinases. ATM is a member of the phosphoinositide 3-kinase-related protein kinase (PIKK) subfamily. PIKKs have intrinsic serine/threonine kinase activity and are distinguished from other PKs by their unique catalytic domain similar to that of lipid PI3K and their large molecular weight (240-470 kDa). ATM contains a FAT (FRAP ATM and TRRAP) domain a catalytic domain and a FATC domain at the C-terminus. ATM is critical in the response to DNA double strand breaks (DSBs) caused by radiation. It is activated at the site of a DSB and phosphorylates key substrates that trigger pathways that regulate DNA repair and cell cycle checkpoints at the G1/S S phase and G2/M transition. Patients with the human genetic disorder Ataxia telangiectasia (A-T) caused by truncating mutations in ATM show genome instability increased cancer risk immunodeficiency compromised mobility and neurodegeneration. A-T displays clinical heterogeneity which is correlated to the degree of retained ATM activity..
rpsblast_cdd gnl|CDD|119418 401 676 + 276 Gaps:41 99.16 237 48.51 4e-76 cd00892 PIKKc_ATR ATR (Ataxia telangiectasia and Rad3-related) catalytic domain The ATR catalytic domain subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as the typical serine/threonine/tyrosine protein kinases (PKs) aminoglycoside phosphotransferase choline kinase and RIO kinases. ATR is also referred to as Mei-41 (Drosophila) Esr1/Mec1p (Saccharomyces cerevisiae) Rad3 (Schizosaccharomyces pombe) and FRAP-related protein (human). ATR is a member of the phosphoinositide 3-kinase-related protein kinase (PIKK) subfamily. PIKKs have intrinsic serine/threonine kinase activity and are distinguished from other PKs by their unique catalytic domain similar to that of lipid PI3K and their large molecular weight (240-470 kDa). ATR contains a UME domain of unknown function a FAT (FRAP ATM and TRRAP) domain a catalytic domain and a FATC domain at the C-terminus. Together with its downstream effector kinase Chk1 ATR plays a central role in regulating the replication checkpoint. ATR stabilizes replication forks by promoting the association of DNA polymerases with the fork. Preventing fork collapse is essential in preserving genomic integrity. ATR plays a role in normal cell growth and in response to DNA damage..
rpsblast_cdd gnl|CDD|119424 403 671 + 269 Gaps:49 99.10 222 49.55 1e-71 cd05164 PIKKc Phosphoinositide 3-kinase-related protein kinase (PIKK) subfamily catalytic domain The PIKK catalytic domain subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as the typical serine/threonine/tyrosine protein kinases (PKs) aminoglycoside phosphotransferase choline kinase and RIO kinases. Members include ATM (Ataxia telangiectasia mutated) ATR (Ataxia telangiectasia and Rad3-related) TOR (Target of rapamycin) SMG-1 (Suppressor of morphogenetic effect on genitalia-1) and DNA-PK (DNA-dependent protein kinase). PIKKs have intrinsic serine/threonine kinase activity and are distinguished from other PKs by their unique catalytic domain similar to that of lipid PI3K and their large molecular weight (240-470 kDa). They show strong preference for phosphorylating serine/threonine residues followed by a glutamine and are also referred to as (S/T)-Q-directed kinases. They all contain a FATC (FRAP ATM and TRRAP C-terminal) domain. PIKKs have diverse functions including cell-cycle checkpoints genome surveillance mRNA surveillance and translation control..
rpsblast_cdd gnl|CDD|34637 241 761 + 521 Gaps:59 22.42 2105 31.36 6e-68 COG5032 TEL1 Phosphatidylinositol kinase and protein kinases of the PI-3 kinase family [Signal transduction mechanisms / Cell division and chromosome partitioning / Chromatin structure and dynamics / DNA replication recombination and repair / Intracellular trafficking and secretion].

22 Domain Motifs

Analysis Begin End Length Domain Identifier Cross Ref Description Inter Pro
ProSiteProfiles 729 761 33 PS51190 none FATC domain profile. IPR003152
Phobius 115 140 26 TRANSMEMBRANE none Region of a membrane-bound protein predicted to be embedded in the membrane. none
ProSiteProfiles 1 298 298 PS51189 none FAT domain profile. IPR014009
Coils 342 363 22 Coil none none none
ProSiteProfiles 430 761 332 PS50290 none Phosphatidylinositol 3- and 4-kinases family profile. IPR000403
Gene3D 338 480 143 G3DSA:3.30.1010.10 none none none
Coils 167 188 22 Coil none none none
SUPERFAMILY 339 508 170 SSF56112 none none IPR011009
SUPERFAMILY 542 688 147 SSF56112 none none IPR011009
Gene3D 730 753 24 G3DSA:1.10.1070.11 none none IPR000403
Gene3D 481 495 15 G3DSA:1.10.1070.11 none none IPR000403
Gene3D 549 693 145 G3DSA:1.10.1070.11 none none IPR000403
Pfam 731 761 31 PF02260 none FATC domain IPR003152
Pfam 436 676 241 PF00454 none Phosphatidylinositol 3- and 4-kinase IPR000403
ProSitePatterns 434 449 16 PS00915 none Phosphatidylinositol 3- and 4-kinases signature 1. IPR018936
ProSitePatterns 571 591 21 PS00916 none Phosphatidylinositol 3- and 4-kinases signature 2. IPR018936
PANTHER 171 761 591 PTHR11139 none none none
PANTHER 5 93 89 PTHR11139 none none none
Coils 708 729 22 Coil none none none
Phobius 1 114 114 CYTOPLASMIC_DOMAIN none Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm. none
Phobius 141 761 621 NON_CYTOPLASMIC_DOMAIN none Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region. none
SMART 431 725 295 SM00146 none Phosphoinositide 3-kinase, catalytic domain IPR000403

1 Localization

Analysis Start End Length
TMHMM 114 136 22

17 Qtllist

Qtl Name Chromosome Name Linkage Group Prox Marker Dist Marker Position QTL Pos One Pos Two Test Type Test Value R 2
Champenoux_2015_nPriLBD_3P Qrob_Chr10 10 v_15000_157 v_15000_310 15,68 15,9 15,91 lod 2.4 5.5
Bourran2_2014_nSecLBD_3P Qrob_Chr08 8 s_1BN2OD_551 s_1B5AYF_599 17,17 0 43,51 lod 1,9229 4,4
Bourran2_2014_nLBD*_3P Qrob_Chr08 8 v_5216_549 v_11837_70 12,25 0 35,55 lod 2,5951 6
Bourran2_2014_nP*_3P Qrob_Chr08 8 v_5216_549 v_11837_70 12,19 0 31,97 lod 2,8472 6
Bourran2_2002_QTL11_peak_Bud_burst_A4 Qrob_Chr06 6 s_1C41PA_791 s_1AM1AV_1141 19,17 0 34,57 lod 2,3 2,9
Bourran2_2014_aSeqBC_3P Qrob_Chr06 6 v_506_189 v_686_77 30,72 13,58 43,48 lod 2,2746 6,3
Bourran2_2014_aSeqBC*_A4 Qrob_Chr06 6 s_2F5MK3_712 v_444_355 27,13 14,86 39,46 lod 3,7847 9,8
Bourran2_2014_nEpis*_3P Qrob_Chr08 8 s_1DA4QW_688 s_1DNI7D_820 17,96 0 37,75 lod 2,9745 7,5
Bourran2_2014_nEpis*_A4 Qrob_Chr07 7 v_12400_446 s_1BPEBU_1211 6,93 0 15,13 lod 4,7411 11
Bourran2_2014_nFork*_3P Qrob_Chr06 6 v_12930_125 s_1AMZEI_909 34,28 7,43 41,48 lod 2,4044 5,5
Bourran2_2014_nLBD_A4 Qrob_Chr06 6 v_12930_125 s_1AMZEI_909 37,41 9,8 50,1 lod 1,9524 4,1
Bourran2_2014_nPriBD_A4 Qrob_Chr06 6 v_12930_125 s_1AMZEI_909 34,51 3,36 51,86 lod 1,6747 3,9
Bourran2_2014_nPriLBD*_3P Qrob_Chr11 11 v_12066_307 s_1B15GJ_447 3,37 0,57 16,17 lod 3,4299 6,9
Bourran2_2014_nSecLBD_A4 Qrob_Chr07 7 v_8327_222 s_1A4WGY_363 16,04 0 44,69 lod 2,6373 6,5
Bourran2_2014_vEpiBC_A4 Qrob_Chr06 6 v_12930_125 s_1AMZEI_909 37,55 14,41 50,01 lod 1,7882 4,8
Champenoux_2015_nEpis_3P Qrob_Chr11 11 s_1DG9PM_867 s_1BZ083_1312 26,53 25,47 27,72 lod 4.4 8.9
Champenoux_2015_nP_3P Qrob_Chr06 6 s_1A386O_228 s_1AYZFS_603 27,03 26,47 27,34 lod 2.8 7.2

0 Targeting