Blast Analysis : gnl|CDD|119431

Analysis  rpsblast_cdd Start  401
End  678 Strand  +
Length  278 Note  Gaps:9
Hit Coverage  100.00 Hit Length  279
Hit Pident  63.80 E Val  1e-143
Hit Description  cd05171 PIKKc_ATM Ataxia telangiectasia mutated (ATM) catalytic domain The ATM catalytic domain subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as the typical serine/threonine/tyrosine protein kinases (PKs) aminoglycoside phosphotransferase choline kinase and RIO kinases. ATM is a member of the phosphoinositide 3-kinase-related protein kinase (PIKK) subfamily. PIKKs have intrinsic serine/threonine kinase activity and are distinguished from other PKs by their unique catalytic domain similar to that of lipid PI3K and their large molecular weight (240-470 kDa). ATM contains a FAT (FRAP ATM and TRRAP) domain a catalytic domain and a FATC domain at the C-terminus. ATM is critical in the response to DNA double strand breaks (DSBs) caused by radiation. It is activated at the site of a DSB and phosphorylates key substrates that trigger pathways that regulate DNA repair and cell cycle checkpoints at the G1/S S phase and G2/M transition. Patients with the human genetic disorder Ataxia telangiectasia (A-T) caused by truncating mutations in ATM show genome instability increased cancer risk immunodeficiency compromised mobility and neurodegeneration. A-T displays clinical heterogeneity which is correlated to the degree of retained ATM activity.. Hit Pcons  15.77
Name  Qrob_P0005700.2
Paste the following link
Lists
This BlastAnalysis isn't in any lists. Upload a list.

1 Protein

Protein Identifier
Organism . Name 		Score Score Type Protein Description Alias (in v1) Code Enzyme Gene Prediction Quality
Qrob_P0005700.2 Quercus robur 18.0 egn (M=1) KOG0889//KOG0890//KOG0891//KOG0892//KOG0903//KOG0904//KOG0905//KOG0906 - Histone acetyltransferase SAGA TRRAP/TRA1 component PI-3 kinase superfamily [Signal transduction mechanisms Chromatin structure and dynamics Replication recombination and repair Cell cycle control cell division chromosome partitioning]. // Protein kinase of the PI-3 kinase family involved in mitotic growth DNA repair and meiotic recombination [Signal transduction mechanisms Chromatin structure and dynamics Replication recombination and repair Cell cycle control cell division chromosome partitioning]. // DNA-dependent protein kinase [Replication recombination and repair]. // Protein kinase ATM/Tel1 involved in telomere length regulation and DNA repair [Signal transduction mechanisms Chromatin structure and dynamics Replication recombination and repair Cell cycle control cell division chromosome partitioning]. // Phosphatidylinositol 4-kinase involved in intracellular trafficking and secretion [Signal transduction mechanisms Intracellular trafficking secretion and vesicular transport]. // Phosphatidylinositol 3-kinase catalytic subunit (p110) [Signal transduction mechanisms]. // Phosphoinositide 3-kinase [Signal transduction mechanisms]. // Phosphatidylinositol 3-kinase VPS34 involved in signal transduction [Signal transduction mechanisms Intracellular trafficking secretion and vesicular transport].   EC:2.7.11.1 validated