Blast Analysis : gnl|CDD|119418

Analysis  rpsblast_cdd Start  401
End  676 Strand  +
Length  276 Note  Gaps:41
Hit Coverage  99.16 Hit Length  237
Hit Pident  48.51 E Val  4e-76
Hit Description  cd00892 PIKKc_ATR ATR (Ataxia telangiectasia and Rad3-related) catalytic domain The ATR catalytic domain subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as the typical serine/threonine/tyrosine protein kinases (PKs) aminoglycoside phosphotransferase choline kinase and RIO kinases. ATR is also referred to as Mei-41 (Drosophila) Esr1/Mec1p (Saccharomyces cerevisiae) Rad3 (Schizosaccharomyces pombe) and FRAP-related protein (human). ATR is a member of the phosphoinositide 3-kinase-related protein kinase (PIKK) subfamily. PIKKs have intrinsic serine/threonine kinase activity and are distinguished from other PKs by their unique catalytic domain similar to that of lipid PI3K and their large molecular weight (240-470 kDa). ATR contains a UME domain of unknown function a FAT (FRAP ATM and TRRAP) domain a catalytic domain and a FATC domain at the C-terminus. Together with its downstream effector kinase Chk1 ATR plays a central role in regulating the replication checkpoint. ATR stabilizes replication forks by promoting the association of DNA polymerases with the fork. Preventing fork collapse is essential in preserving genomic integrity. ATR plays a role in normal cell growth and in response to DNA damage.. Hit Pcons  17.45
Name  Qrob_P0005700.2
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1 Protein

Protein Identifier
Organism . Name 		Score Score Type Protein Description Alias (in v1) Code Enzyme Gene Prediction Quality
Qrob_P0005700.2 Quercus robur 18.0 egn (M=1) KOG0889//KOG0890//KOG0891//KOG0892//KOG0903//KOG0904//KOG0905//KOG0906 - Histone acetyltransferase SAGA TRRAP/TRA1 component PI-3 kinase superfamily [Signal transduction mechanisms Chromatin structure and dynamics Replication recombination and repair Cell cycle control cell division chromosome partitioning]. // Protein kinase of the PI-3 kinase family involved in mitotic growth DNA repair and meiotic recombination [Signal transduction mechanisms Chromatin structure and dynamics Replication recombination and repair Cell cycle control cell division chromosome partitioning]. // DNA-dependent protein kinase [Replication recombination and repair]. // Protein kinase ATM/Tel1 involved in telomere length regulation and DNA repair [Signal transduction mechanisms Chromatin structure and dynamics Replication recombination and repair Cell cycle control cell division chromosome partitioning]. // Phosphatidylinositol 4-kinase involved in intracellular trafficking and secretion [Signal transduction mechanisms Intracellular trafficking secretion and vesicular transport]. // Phosphatidylinositol 3-kinase catalytic subunit (p110) [Signal transduction mechanisms]. // Phosphoinositide 3-kinase [Signal transduction mechanisms]. // Phosphatidylinositol 3-kinase VPS34 involved in signal transduction [Signal transduction mechanisms Intracellular trafficking secretion and vesicular transport].   EC:2.7.11.1 validated