GO Term : GO:0039583 suppression by virus of host PKR activity by positive regulation of PKR catabolic process GO
Namespace  biological_process Obsolete  false
description  Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of host PKR (protein kinase regulated by RNA) activity by promoting the degradation of PKR via the proteosome. For example, the Rift Valley fever virus (RVFV) NSs protein induces the down-regulation of PKR by degradation through proteasomes.
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0 Cross References

1 Ontology

Name
GO

193 Parents

Identifier Name Description
GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation.
GO:0006468 protein phosphorylation The process of introducing a phosphate group on to a protein.
GO:0051603 proteolysis involved in cellular protein catabolic process The hydrolysis of a peptide bond or bonds within a protein as part of the chemical reactions and pathways resulting in the breakdown of a protein by individual cells.
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome.
GO:0006511 ubiquitin-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein.
GO:0006508 proteolysis The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds.
GO:0001932 regulation of protein phosphorylation Any process that modulates the frequency, rate or extent of addition of phosphate groups into an amino acid in a protein.
GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances.
GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack.
GO:0009607 response to biotic stimulus Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a biotic stimulus, a stimulus caused or produced by a living organism.
GO:0006950 response to stress Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation).
GO:0006464 cellular protein modification process The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications) occurring at the level of an individual cell. Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification).
GO:0016310 phosphorylation The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide.
GO:0006796 phosphate-containing compound metabolic process The chemical reactions and pathways involving the phosphate group, the anion or salt of any phosphoric acid.
GO:0071704 organic substance metabolic process The chemical reactions and pathways involving an organic substance, any molecular entity containing carbon.
GO:0019538 protein metabolic process The chemical reactions and pathways involving a specific protein, rather than of proteins in general. Includes protein modification.
GO:0031347 regulation of defense response Any process that modulates the frequency, rate or extent of a defense response.
GO:0030163 protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds.
GO:0042176 regulation of protein catabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds.
GO:0043412 macromolecule modification The covalent alteration of one or more monomeric units in a polypeptide, polynucleotide, polysaccharide, or other biological macromolecule, resulting in a change in its properties.
GO:0050790 regulation of catalytic activity Any process that modulates the activity of an enzyme.
GO:0044238 primary metabolic process The chemical reactions and pathways involving those compounds which are formed as a part of the normal anabolic and catabolic processes. These processes take place in most, if not all, cells of the organism.
GO:0009987 cellular process Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.
GO:0008150 biological_process Any process specifically pertinent to the functioning of integrated living units: cells, tissues, organs, and organisms. A process is a collection of molecular events with a defined beginning and end.
GO:0050896 response to stimulus Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. The process begins with detection of the stimulus and ends with a change in state or activity or the cell or organism.
GO:0044260 cellular macromolecule metabolic process The chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass, as carried out by individual cells.
GO:0043170 macromolecule metabolic process The chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.
GO:0031323 regulation of cellular metabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform chemical substances.
GO:0080090 regulation of primary metabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism involving those compounds formed as a part of the normal anabolic and catabolic processes. These processes take place in most, if not all, cells of the organism.
GO:0065007 biological regulation Any process that modulates a measurable attribute of any biological process, quality or function.

0 Protein

260 Relations

Relationship
Parent Term . Identifier
Child Term . Identifier
is_a GO:0039580 GO:0039583
is_a GO:0032436 GO:0039583
is_a GO:0045824 GO:0039583
is_a GO:0050789 GO:0039583
is_a GO:1903050 GO:0039583
is_a GO:0052203 GO:0039583
is_a GO:0052204 GO:0039583
is_a GO:1903052 GO:0039583
is_a GO:0052200 GO:0039583
is_a GO:0050687 GO:0039583
is_a GO:0050688 GO:0039583
part of GO:0044403 GO:0039583
part of GO:0051704 GO:0039583
is_a GO:0030683 GO:0039583
negatively regulates GO:0009605 GO:0039583
regulates GO:0044248 GO:0039583
is_a GO:0030682 GO:0039583
is_a GO:0052205 GO:0039583
regulates GO:0006468 GO:0039583
is_a GO:0032270 GO:0039583
negatively regulates GO:0009607 GO:0039583
is_a GO:0052031 GO:0039583
regulates GO:0006464 GO:0039583
is_a GO:0065009 GO:0039583
part of GO:0044419 GO:0039583
is_a GO:0010604 GO:0039583
positively regulates GO:0019538 GO:0039583
is_a GO:0010605 GO:0039583
is_a GO:0052037 GO:0039583
positively regulates GO:0009056 GO:0039583

2 Synonyms

Name Type
promotion by virus of proteosome-dependent PKR degradation synonym
downregulation of PKR by degradation through proteosome synonym