GO Term : GO:0031511 Mis6-Sim4 complex GO

Namespace  cellular_component Obsolete  false
description  A protein complex that forms part of the inner centromere, which is involved in the loading of the centromeric histone h3 variant CENP-A onto centromeres and in centromere specific heterochromatin formation. The complex contains about 12 proteins, of which two are known as Mis6 and Sim4 in S. pombe and CENP-I and CENP-H in human.

0 Cross References

1 Ontology

Name
GO

23 Parents

Identifier Name Description
GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm.
GO:0000775 chromosome, centromeric region The region of a chromosome that includes the centromeric DNA and associated proteins. In monocentric chromosomes, this region corresponds to a single area of the chromosome, whereas in holocentric chromosomes, it is evenly distributed along the chromosome.
GO:0005694 chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information.
GO:0043234 protein complex A stable macromolecular complex composed (only) of two or more polypeptide subunits along with any covalently attached molecules (such as lipid anchors or oligosaccharide) or non-protein prosthetic groups (such as nucleotides or metal ions). Prosthetic group in this context refers to a tightly bound cofactor. The component polypeptide subunits may be identical.
GO:0000776 kinetochore A multisubunit complex that is located at the centromeric region of DNA and provides an attachment point for the spindle microtubules.
GO:0044424 intracellular part Any constituent part of the living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm.
GO:0005623 cell The basic structural and functional unit of all organisms. Includes the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope.
GO:0032991 macromolecular complex A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which the constituent parts function together.
GO:0044464 cell part Any constituent part of a cell, the basic structural and functional unit of all organisms.
GO:0005575 cellular_component The part of a cell or its extracellular environment in which a gene product is located. A gene product may be located in one or more parts of a cell and its location may be as specific as a particular macromolecular complex, that is, a stable, persistent association of macromolecules that function together.
GO:0044422 organelle part Any constituent part of an organelle, an organized structure of distinctive morphology and function. Includes constituent parts of the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton, but excludes the plasma membrane.
GO:0044446 intracellular organelle part A constituent part of an intracellular organelle, an organized structure of distinctive morphology and function, occurring within the cell. Includes constituent parts of the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton but excludes the plasma membrane.
GO:0043226 organelle Organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton, and prokaryotic structures such as anammoxosomes and pirellulosomes. Excludes the plasma membrane.
GO:0043229 intracellular organelle Organized structure of distinctive morphology and function, occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane.
GO:0043228 non-membrane-bounded organelle Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane. Includes ribosomes, the cytoskeleton and chromosomes.
GO:0043232 intracellular non-membrane-bounded organelle Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane and occurring within the cell. Includes ribosomes, the cytoskeleton and chromosomes.
GO:0000777 condensed chromosome kinetochore A multisubunit complex that is located at the centromeric region of a condensed chromosome and provides an attachment point for the spindle microtubules.
GO:0044427 chromosomal part Any constituent part of a chromosome, a structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information.
GO:0000779 condensed chromosome, centromeric region The region of a condensed chromosome that includes the centromere and associated proteins, including the kinetochore. In monocentric chromosomes, this region corresponds to a single area of the chromosome, whereas in holocentric chromosomes, it is evenly distributed along the chromosome.
GO:0000793 condensed chromosome A highly compacted molecule of DNA and associated proteins resulting in a cytologically distinct structure.
GO:0098687 chromosomal region Any subdivision of a chromosome along its length.
GO:0000939 condensed chromosome inner kinetochore The region of a condensed chromosome kinetochore closest to centromeric DNA; in mammals the CREST antigens (CENP proteins) are found in this layer; this layer may help define underlying centromeric chromatin structure and position of the kinetochore on the chromosome.
GO:0031511 Mis6-Sim4 complex A protein complex that forms part of the inner centromere, which is involved in the loading of the centromeric histone h3 variant CENP-A onto centromeres and in centromere specific heterochromatin formation. The complex contains about 12 proteins, of which two are known as Mis6 and Sim4 in S. pombe and CENP-I and CENP-H in human.

0 Protein

30 Relations

Relationship
Parent Term . Identifier

Child Term . Identifier
is_a GO:0043234 GO:0031511
is_a GO:0044427 GO:0031511
part of GO:0000939 GO:0031511
part of GO:0005575 GO:0031511
part of GO:0098687 GO:0031511
is_a GO:0044464 GO:0031511
part of GO:0043226 GO:0031511
part of GO:0043228 GO:0031511
part of GO:0000793 GO:0031511
part of GO:0043234 GO:0031511
part of GO:0005694 GO:0031511
part of GO:0043232 GO:0031511
is_a GO:0005575 GO:0031511
part of GO:0044422 GO:0031511
part of GO:0005622 GO:0031511
is_a GO:0044424 GO:0031511
part of GO:0044427 GO:0031511
part of GO:0043229 GO:0031511
part of GO:0044424 GO:0031511
is_a GO:0044446 GO:0031511
part of GO:0044464 GO:0031511
part of GO:0044446 GO:0031511
part of GO:0032991 GO:0031511
part of GO:0000775 GO:0031511
part of GO:0000776 GO:0031511
is_a GO:0044422 GO:0031511
part of GO:0000777 GO:0031511
part of GO:0005623 GO:0031511
is_a GO:0032991 GO:0031511
part of GO:0000779 GO:0031511

3 Synonyms

Name Type
Sim4 complex synonym
Mis6 centromere subcomplex synonym
Mis6-Mal2-Sim4 centromere complex synonym