GO Term : GO:0004498 calcidiol 1-monooxygenase activity GO

Namespace  molecular_function Obsolete  false
description  Catalysis of the reaction: calcidiol + H(+) + NADPH + O(2) = calcitriol + H(2)O + NADP(+).

0 Cross References

1 Ontology

Name
GO

7 Parents

Identifier Name Description
GO:0016491 oxidoreductase activity Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced.
GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor.
GO:0003824 catalytic activity Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic.
GO:0004497 monooxygenase activity Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water.
GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from NADH or NADPH and one other donor, and one atom of oxygen is incorporated into one donor.
GO:0003674 molecular_function Elemental activities, such as catalysis or binding, describing the actions of a gene product at the molecular level. A given gene product may exhibit one or more molecular functions.
GO:0004498 calcidiol 1-monooxygenase activity Catalysis of the reaction: calcidiol + H(+) + NADPH + O(2) = calcitriol + H(2)O + NADP(+).

0 Protein

6 Relations

Relationship
Parent Term . Identifier

Child Term . Identifier
is_a GO:0016709 GO:0004498
is_a GO:0016705 GO:0004498
is_a GO:0004497 GO:0004498
is_a GO:0003674 GO:0004498
is_a GO:0016491 GO:0004498
is_a GO:0003824 GO:0004498

12 Synonyms

Name Type
calcidiol,NADPH:oxygen oxidoreductase (1-hydroxylating) synonym
cytochrome P450 CYP27B synonym
25-hydroxyvitamin D3 1alpha-hydroxylase activity synonym
25-OHD-1 alpha-hydroxylase activity synonym
25-hydroxycholecalciferol-1-hydroxylase activity synonym
25-hydroxyvitamin D-1 alpha hydroxylase activity synonym
25-hydroxycholecalciferol 1-monooxygenase activity synonym
25-hydroxycholecalciferol 1alpha-hydroxylase activity synonym
25-hydroxycholecalciferol 1-hydroxylase activity synonym
25-hydroxy vitamin D3 1-alpha-hydroxylase activity synonym
25-hydroxy D3-1alpha-hydroxylase activity synonym
1-hydroxylase-25-hydroxyvitamin D3 activity synonym