GO Term : GO:0003957 NAD(P)+ transhydrogenase (B-specific) activity GO

Namespace  molecular_function Obsolete  false
description  Catalysis of the reaction: NADPH + H+ + NAD+ = NADP+ + NADH + H+, driving the transfer of a solute or solutes from one side of a membrane to the other. In the course of the reaction (left to right) one H atom is transferred from inside the cell to outside. The reaction is B-specific (i.e. the pro-S hydrogen is transferred from the 4-position of reduced nicotinamide cofactor) with respect to both NAD+ and NADP+.

0 Cross References

1 Ontology

Name
GO

16 Parents

Identifier Name Description
GO:0016491 oxidoreductase activity Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced.
GO:0003824 catalytic activity Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic.
GO:0022857 transmembrane transporter activity Enables the transfer of a substance from one side of a membrane to the other.
GO:0022891 substrate-specific transmembrane transporter activity Enables the transfer of a specific substance or group of related substances from one side of a membrane to the other.
GO:0005215 transporter activity Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells.
GO:0008324 cation transmembrane transporter activity Enables the transfer of cation from one side of the membrane to the other.
GO:0016651 oxidoreductase activity, acting on NAD(P)H Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor.
GO:0015078 hydrogen ion transmembrane transporter activity Enables the transfer of hydrogen ions from one side of a membrane to the other.
GO:0015075 ion transmembrane transporter activity Enables the transfer of an ion from one side of a membrane to the other.
GO:0003674 molecular_function Elemental activities, such as catalysis or binding, describing the actions of a gene product at the molecular level. A given gene product may exhibit one or more molecular functions.
GO:0022890 inorganic cation transmembrane transporter activity Enables the transfer of inorganic cations from one side of a membrane to the other. Inorganic cations are atoms or small molecules with a positive charge that do not contain carbon in covalent linkage.
GO:0022892 substrate-specific transporter activity Enables the directed movement of a specific substance or group of related substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells.
GO:0015077 monovalent inorganic cation transmembrane transporter activity Enables the transfer of a inorganic cations with a valency of one from one side of a membrane to the other. Inorganic cations are atoms or small molecules with a positive charge that do not contain carbon in covalent linkage.
GO:0003957 NAD(P)+ transhydrogenase (B-specific) activity Catalysis of the reaction: NADPH + H+ + NAD+ = NADP+ + NADH + H+, driving the transfer of a solute or solutes from one side of a membrane to the other. In the course of the reaction (left to right) one H atom is transferred from inside the cell to outside. The reaction is B-specific (i.e. the pro-S hydrogen is transferred from the 4-position of reduced nicotinamide cofactor) with respect to both NAD+ and NADP+.
GO:0008746 NAD(P)+ transhydrogenase activity Catalysis of the reaction: NADPH + H+ + NAD+ = NADP+ + NADH + H+.
GO:0016652 oxidoreductase activity, acting on NAD(P)H, NAD(P) as acceptor Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces NAD+ or NADP.

0 Protein

15 Relations

Relationship
Parent Term . Identifier

Child Term . Identifier
is_a GO:0008746 GO:0003957
is_a GO:0015078 GO:0003957
is_a GO:0005215 GO:0003957
is_a GO:0015077 GO:0003957
is_a GO:0022892 GO:0003957
is_a GO:0016652 GO:0003957
is_a GO:0022891 GO:0003957
is_a GO:0022857 GO:0003957
is_a GO:0016651 GO:0003957
is_a GO:0015075 GO:0003957
is_a GO:0003674 GO:0003957
is_a GO:0016491 GO:0003957
is_a GO:0003824 GO:0003957
is_a GO:0022890 GO:0003957
is_a GO:0008324 GO:0003957

14 Synonyms

Name Type
nicotinamide adenine dinucleotide (phosphate) transhydrogenase synonym
pyridine nucleotide transferase synonym
NADH-NADP-transhydrogenase synonym
NADPH-NAD oxidoreductase synonym
NADPH-NAD transhydrogenase synonym
NADPH:NAD+ transhydrogenase synonym
H+-thase synonym
NAD transhydrogenase synonym
NADH transhydrogenase synonym
pyridine nucleotide transhydrogenase activity synonym
NAD(P) transhydrogenase (B-specific) activity synonym
nicotinamide nucleotide transhydrogenase activity synonym
NADPH:NAD+ oxidoreductase (B-specific) synonym
non-energy-linked transhydrogenase activity synonym