GO Term : GO:0016987 sigma factor activity GO

Namespace  molecular_function Obsolete  false
description  A sigma factor is the promoter specificity subunit of eubacterial-type multisubunit RNA polymerases, those whose core subunit composition is often described as alpha(2)-beta-beta-prime. (This type of multisubunit RNA polymerase complex is known to be found in eubacteria and plant plastids). Although sigma does not bind DNA on its own, when combined with the core to form the holoenzyme, this binds specifically to promoter sequences, with the sigma factor making sequence specific contacts with the promoter elements. The sigma subunit is released from the elongating form of the polymerase and is thus free to act catalytically for multiple RNA polymerase core enzymes.

0 Cross References

1 Ontology

Name
GO

5 Parents

Identifier Name Description
GO:0016987 sigma factor activity A sigma factor is the promoter specificity subunit of eubacterial-type multisubunit RNA polymerases, those whose core subunit composition is often described as alpha(2)-beta-beta-prime. (This type of multisubunit RNA polymerase complex is known to be found in eubacteria and plant plastids). Although sigma does not bind DNA on its own, when combined with the core to form the holoenzyme, this binds specifically to promoter sequences, with the sigma factor making sequence specific contacts with the promoter elements. The sigma subunit is released from the elongating form of the polymerase and is thus free to act catalytically for multiple RNA polymerase core enzymes.
GO:0003674 molecular_function Elemental activities, such as catalysis or binding, describing the actions of a gene product at the molecular level. A given gene product may exhibit one or more molecular functions.
GO:0000988 protein binding transcription factor activity Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules), in order to modulate transcription. A protein binding transcription factor may or may not also interact with the template nucleic acid (either DNA or RNA) as well.
GO:0000990 core RNA polymerase binding transcription factor activity Interacting selectively and non-covalently with an RNA polymerase in order to modulate transcription. A protein binding transcription factor may or may not also interact with the template nucleic acid (either DNA or RNA) as well.
GO:0000996 core DNA-dependent RNA polymerase binding promoter specificity activity Interacting selectively and non-covalently with a DNA-dependent core RNA polymerase to form a holoenzyme complex and also, while present in the holoenzyme, interacting with promoter sequences in order to confer sequence specific recognition of promoter DNA sequence motifs.

5 Protein

Protein Identifier
Organism . Name
Score Score Type Protein Description Alias (in v1) Code Enzyme Gene Prediction Quality
Qrob_P0321750.2 Quercus robur 100.0 egn (M=1) PTHR30603:SF4 - RNA POLYMERASE SIGMA FACTOR SIGE, CHLOROPLASTIC/MITOCHONDRIAL (PTHR30603:SF4)     validated
Qrob_P0328830.2 Quercus robur 100.0 egn (M=1) PTHR30603:SF9 - RNA POLYMERASE SIGMA FACTOR SIGF, CHLOROPLASTIC (PTHR30603:SF9)     validated
Qrob_P0595300.2 Quercus robur 92.0 egn (M=1) PTHR30603:SF0 - RNA POLYMERASE SIGMA FACTOR RPO     validated
Qrob_P0708870.2 Quercus robur 100.0 egn (M=1) K03086 - RNA polymerase primary sigma factor     validated
Qrob_P0736490.2 Quercus robur 100.0 egn (M=1) K03093 - RNA polymerase sigma factor     validated

5 Relations

Relationship
Parent Term . Identifier

Child Term . Identifier
is_a GO:0016987 GO:0001053
is_a GO:0000996 GO:0016987
is_a GO:0000990 GO:0016987
is_a GO:0000988 GO:0016987
is_a GO:0003674 GO:0016987

1 Synonyms

Name Type
sigma transcription factor synonym