GO Term : GO:0004489 methylenetetrahydrofolate reductase (NAD(P)H) activity GO

Namespace  molecular_function Obsolete  false
description  Catalysis of the reaction: 5-methyltetrahydrofolate + NAD(P)+ = 5,10-methylenetetrahydrofolate + NAD(P)H + H+.

0 Cross References

1 Ontology

Name
GO

6 Parents

Identifier Name Description
GO:0016491 oxidoreductase activity Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced.
GO:0003824 catalytic activity Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic.
GO:0004489 methylenetetrahydrofolate reductase (NAD(P)H) activity Catalysis of the reaction: 5-methyltetrahydrofolate + NAD(P)+ = 5,10-methylenetetrahydrofolate + NAD(P)H + H+.
GO:0003674 molecular_function Elemental activities, such as catalysis or binding, describing the actions of a gene product at the molecular level. A given gene product may exhibit one or more molecular functions.
GO:0016646 oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH group acts as a hydrogen or electron donor and reduces NAD or NADP.
GO:0016645 oxidoreductase activity, acting on the CH-NH group of donors Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor.

1 Protein

Protein Identifier
Organism . Name
Score Score Type Protein Description Alias (in v1) Code Enzyme Gene Prediction Quality
Qrob_P0032570.2 Quercus robur 100.0 egn (M=1) 1.5.1.20 - Methylenetetrahydrofolate reductase (NAD(P)H).   EC:1.5.1.20 validated

5 Relations

Relationship
Parent Term . Identifier

Child Term . Identifier
is_a GO:0016646 GO:0004489
is_a GO:0003674 GO:0004489
is_a GO:0016645 GO:0004489
is_a GO:0003824 GO:0004489
is_a GO:0016491 GO:0004489

31 Synonyms

Name Type
5,10-methylenetetrahydrofolate reductase (FADH(2)) activity synonym
5,10-methylenetetrahydrofolate reductase (FADH) activity synonym
5,10-methylenetetrahydrofolate reductase (FADH2) activity synonym
5,10-methylenetetrahydrofolate reductase (NADPH) activity synonym
5,10-methylenetetrahydrofolic acid reductase activity synonym
5,10-methylenetetrahydropteroylglutamate reductase activity synonym
5-methyltetrahydrofolate:(acceptor) oxidoreductase activity synonym
5-methyltetrahydrofolate:NAD oxidoreductase activity synonym
5-methyltetrahydrofolate:NAD(+) oxidoreductase activity synonym
5-methyltetrahydrofolate:NAD(P)+ oxidoreductase activity synonym
5-methyltetrahydrofolate:NAD+ oxidoreductase activity synonym
5-methyltetrahydrofolate:NADP(+) oxidoreductase activity synonym
5-methyltetrahydrofolate:NADP+ oxidoreductase activity synonym
5,10-methylenetetrahydrofolate reductase activity synonym
MetF synonym
methylenetetrahydrofolate (reduced nicotinamide adenine dinucleotide phosphate) reductase activity synonym
methylenetetrahydrofolate (reduced riboflavin adenine dinucleotide) reductase activity synonym
methylenetetrahydrofolate reductase activity synonym
methylenetetrahydrofolate reductase [NAD(P)H] synonym
methylenetetrahydrofolate reductase (NADPH2) synonym
methylenetetrahydrofolate reductase (NADPH(2)) activity synonym
N(5,10)-methylenetetrahydrofolate reductase activity synonym
N(5),N(10)-methylenetetrahydrofolate reductase activity synonym
MTHFR activity synonym
methylenetetrahydrofolic acid reductase activity synonym
GO:0008702 alt_id
N5,N10-methylenetetrahydrofolate reductase activity synonym
N5,10-methylenetetrahydrofolate reductase activity synonym
1.7.99.5 synonym
5,10-CH2-H4folate reductase activity synonym