Protein : Qrob_P0649410.2 Q. robur
Protein Identifier  ? Qrob_P0649410.2 Organism . Name  Quercus robur
Score  100.0 Score Type  egn
Protein Description  (M=1) K03126 - transcription initiation factor TFIID subunit 12 Gene Prediction Quality  validated
Protein length 

Sequence

Length: 292  
Kegg Orthology  K03126
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0 Synonyms

3 GO Terms

Identifier Name Description
GO:0006352 DNA-templated transcription, initiation Any process involved in the assembly of the RNA polymerase preinitiation complex (PIC) at the core promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter. The initiation phase includes PIC assembly and the formation of the first few bonds in the RNA chain, including abortive initiation, which occurs when the first few nucleotides are repeatedly synthesized and then released. The initiation phase ends just before and does not include promoter clearance, or release, which is the transition between the initiation and elongation phases of transcription.
GO:0046982 protein heterodimerization activity Interacting selectively and non-covalently with a nonidentical protein to form a heterodimer.
GO:0005669 transcription factor TFIID complex A complex composed of TATA binding protein (TBP) and TBP associated factors (TAFs); the total mass is typically about 800 kDa. Most of the TAFs are conserved across species. In TATA-containing promoters for RNA polymerase II (Pol II), TFIID is believed to recognize at least two distinct elements, the TATA element and a downstream promoter element. TFIID is also involved in recognition of TATA-less Pol II promoters. Binding of TFIID to DNA is necessary but not sufficient for transcription initiation from most RNA polymerase II promoters.

26 Blast

Analysis Hit Start End Strand Length Note Hit Coverage Hit Length Hit Pident E Val Hit Description
blastp_kegg lcl|vvi:100242486 1 288 + 288 Gaps:3 58.27 496 75.09 8e-135 uncharacterized LOC100242486
blastp_kegg lcl|tcc:TCM_022533 1 288 + 288 Gaps:5 51.25 560 71.78 2e-126 Transcription initiation factor TFIID subunit 12 putative isoform 1
blastp_kegg lcl|cic:CICLE_v10011440mg 1 285 + 285 Gaps:6 53.07 537 70.18 2e-125 hypothetical protein
blastp_kegg lcl|cit:102608341 1 285 + 285 Gaps:6 52.97 538 70.18 1e-124 transcription initiation factor TFIID subunit 12-like
blastp_kegg lcl|pmum:103339703 1 290 + 290 Gaps:47 57.27 578 62.54 3e-122 transcription initiation factor TFIID subunit 12
blastp_kegg lcl|rcu:RCOM_0515670 6 285 + 280 Gaps:20 62.97 451 70.77 1e-121 protein with unknown function
blastp_kegg lcl|pxb:103963633 14 285 + 272 Gaps:31 51.18 592 65.68 2e-121 transcription initiation factor TFIID subunit 12-like
blastp_kegg lcl|pop:POPTR_0006s08360g 1 288 + 288 Gaps:5 57.75 497 68.64 2e-121 POPTRDRAFT_560743 transcription initiation factor IID subunit A family protein
blastp_kegg lcl|cam:101513367 1 285 + 285 Gaps:4 54.49 523 64.91 2e-115 transcription initiation factor TFIID subunit 12-like
blastp_kegg lcl|pper:PRUPE_ppa017159mg 1 290 + 290 Gaps:36 50.29 509 72.27 1e-112 hypothetical protein
blastp_pdb 1h3o_D 155 224 + 70 none 92.11 76 51.43 4e-20 mol:protein length:76 TRANSCRIPTION INITIATION FACTOR TFIID 20/15 K
blastp_pdb 1h3o_B 155 224 + 70 none 92.11 76 51.43 4e-20 mol:protein length:76 TRANSCRIPTION INITIATION FACTOR TFIID 20/15 K
blastp_uniprot_sprot sp|Q9SR71|TAF12_ARATH 1 288 + 288 Gaps:15 52.13 539 59.43 3e-80 Transcription initiation factor TFIID subunit 12 OS Arabidopsis thaliana GN TAF12 PE 1 SV 1
blastp_uniprot_sprot sp|B2C6R6|TAFCL_ARATH 115 289 + 175 Gaps:8 24.82 681 44.38 6e-39 Transcription initiation factor TFIID subunit 12b OS Arabidopsis thaliana GN TAF12B PE 1 SV 1
blastp_uniprot_sprot sp|Q940A7|TA12B_ARATH 115 289 + 175 Gaps:8 24.74 683 44.38 7e-39 Transcription initiation factor TFIID subunit 12b OS Arabidopsis thaliana GN TAF12B PE 1 SV 1
blastp_uniprot_sprot sp|Q91858|TAF12_XENLA 153 256 + 104 none 63.41 164 50.00 2e-35 Transcription initiation factor TFIID subunit 12 OS Xenopus laevis GN taf12 PE 2 SV 1
blastp_uniprot_sprot sp|Q8VE65|TAF12_MOUSE 153 256 + 104 none 64.60 161 49.04 2e-34 Transcription initiation factor TFIID subunit 12 OS Mus musculus GN Taf12 PE 1 SV 1
blastp_uniprot_sprot sp|Q16514|TAF12_HUMAN 153 256 + 104 none 64.60 161 49.04 2e-34 Transcription initiation factor TFIID subunit 12 OS Homo sapiens GN TAF12 PE 1 SV 1
blastp_uniprot_sprot sp|Q3T174|TAF12_BOVIN 153 256 + 104 none 64.60 161 49.04 2e-34 Transcription initiation factor TFIID subunit 12 OS Bos taurus GN TAF12 PE 2 SV 1
blastp_uniprot_sprot sp|Q555L9|TAF12_DICDI 155 265 + 111 Gaps:1 17.86 627 50.00 3e-31 Transcription initiation factor TFIID subunit 12 OS Dictyostelium discoideum GN TAF12 PE 3 SV 2
blastp_uniprot_sprot sp|Q03761|TAF12_YEAST 154 279 + 126 Gaps:13 22.82 539 44.72 1e-27 Transcription initiation factor TFIID subunit 12 OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN TAF12 PE 1 SV 1
blastp_uniprot_sprot sp|O13722|TAF12_SCHPO 150 257 + 108 Gaps:3 24.67 450 53.15 9e-26 Transcription initiation factor TFIID subunit 12 OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN taf12 PE 1 SV 1
rpsblast_cdd gnl|CDD|112650 157 223 + 67 none 100.00 67 65.67 6e-29 pfam03847 TFIID_20kDa Transcription initiation factor TFIID subunit A.
rpsblast_cdd gnl|CDD|173964 155 226 + 72 none 100.00 72 59.72 3e-28 cd07981 TAF12 TATA Binding Protein (TBP) Associated Factor 12 (TAF12) is one of several TAFs that bind TBP and is involved in forming Transcription Factor IID (TFIID) complex. The TATA Binding Protein (TBP) Associated Factor 12 (TAF12) is one of several TAFs that bind TBP and are involved in forming the TFIID complex. TFIID is one of the seven General Transcription Factors (GTFs) (TFIIA TFIIB TFIID TFIIE TFIIF and TFIID) that are involved in accurate initiation of transcription by RNA polymerase II in eukaryotes. TFIID plays an important role in the recognition of promoter DNA and assembly of the pre-initiation complex. TFIID complex is composed of the TBP and at least 13 TAFs. TAFs are named after their electrophoretic mobility in polyacrylamide gels in different species. A new unified nomenclature has been suggested for the pol II TAFs to show the relationship between TAF orthologs and paralogs. Several hypotheses are proposed for TAFs function such as serving as activator-binding sites core-promoter recognition or a role in essential catalytic activity. These TAFs with the help of specific activators are required only for expression of a subset of genes and are not universally involved for transcription as are GTFs. In yeast and human cells TAFs have been found as components of other complexes besides TFIID. Several TAFs interact via histone-fold (HFD) motifs the HFD is the interaction motif involved in heterodimerization of the core histones and their assembly into nucleosome octamers. The minimal HFD contains three alpha-helices linked by two loops and is found in core histones TAFs and many other transcription factors. TFIID has a histone octamer-like substructure. TAF12 domain interacts with TAF4 and makes a novel histone-like heterodimer that binds DNA and has a core promoter function of a subset of genes.
rpsblast_cdd gnl|CDD|35183 4 259 + 256 Gaps:18 50.69 505 28.12 9e-19 COG5624 TAF61 Transcription initiation factor TFIID subunit TAF12 (also component of histone acetyltransferase SAGA) [Transcription].
rpsblast_kog gnl|CDD|36357 15 259 + 245 Gaps:7 93.02 258 35.83 5e-32 KOG1142 KOG1142 KOG1142 Transcription initiation factor TFIID subunit TAF12 (also component of histone acetyltransferase SAGA) [Transcription].

6 Domain Motifs

Analysis Begin End Length Domain Identifier Cross Ref Description Inter Pro
ProDom 142 227 86 PD012998 none FACTOR INITIATION TRANSCRIPTION TFIID SUBUNIT DNA POLYMERASE TBP-ASSOCIATED TAF12 TATA IPR003228
Gene3D 153 225 73 G3DSA:1.10.20.10 none none IPR009072
PANTHER 12 286 275 PTHR12264:SF21 none none none
SUPERFAMILY 154 225 72 SSF47113 none none IPR009072
PANTHER 12 286 275 PTHR12264 none none none
Pfam 157 224 68 PF03847 none Transcription initiation factor TFIID subunit A IPR003228

0 Localization

1 Qtllist

Qtl Name Chromosome Name Linkage Group Prox Marker Dist Marker Position QTL Pos One Pos Two Test Type Test Value R 2
Bourran2_2015_nEpiBC_A4 Qrob_Chr07 7 s_1DP9TW_798 v_8128_173 22,61 22,14 22,73 lod 3.1 8.5

0 Targeting