| Analysis | rpsblast_cdd | Start | 155 |
| End | 226 | Strand | + |
| Length | 72 | Note | none |
| Hit Coverage | 100.00 | Hit Length | 72 |
| Hit Pident | 59.72 | E Val | 3e-28 |
| Hit Description | cd07981 TAF12 TATA Binding Protein (TBP) Associated Factor 12 (TAF12) is one of several TAFs that bind TBP and is involved in forming Transcription Factor IID (TFIID) complex. The TATA Binding Protein (TBP) Associated Factor 12 (TAF12) is one of several TAFs that bind TBP and are involved in forming the TFIID complex. TFIID is one of the seven General Transcription Factors (GTFs) (TFIIA TFIIB TFIID TFIIE TFIIF and TFIID) that are involved in accurate initiation of transcription by RNA polymerase II in eukaryotes. TFIID plays an important role in the recognition of promoter DNA and assembly of the pre-initiation complex. TFIID complex is composed of the TBP and at least 13 TAFs. TAFs are named after their electrophoretic mobility in polyacrylamide gels in different species. A new unified nomenclature has been suggested for the pol II TAFs to show the relationship between TAF orthologs and paralogs. Several hypotheses are proposed for TAFs function such as serving as activator-binding sites core-promoter recognition or a role in essential catalytic activity. These TAFs with the help of specific activators are required only for expression of a subset of genes and are not universally involved for transcription as are GTFs. In yeast and human cells TAFs have been found as components of other complexes besides TFIID. Several TAFs interact via histone-fold (HFD) motifs the HFD is the interaction motif involved in heterodimerization of the core histones and their assembly into nucleosome octamers. The minimal HFD contains three alpha-helices linked by two loops and is found in core histones TAFs and many other transcription factors. TFIID has a histone octamer-like substructure. TAF12 domain interacts with TAF4 and makes a novel histone-like heterodimer that binds DNA and has a core promoter function of a subset of genes. | Hit Pcons | 19.44 |
| Name | Qrob_P0649410.2 |
| Protein Identifier |
Organism . Name |
Score | Score Type | Protein Description | Alias (in v1) | Code Enzyme | Gene Prediction Quality |
|---|---|---|---|---|---|---|---|
| Qrob_P0649410.2 | Quercus robur | 100.0 | egn | (M=1) K03126 - transcription initiation factor TFIID subunit 12 | validated |
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