Protein : Qrob_P0492510.2 Q. robur
Protein Identifier  ? Qrob_P0492510.2 Organism . Name  Quercus robur
Score  100.0 Score Type  egn
Protein Description  (M=2) PTHR12604 - KU AUTOANTIGEN DNA HELICASE Code Enzyme  EC:3.6.4.12
Gene Prediction Quality  validated Protein length 

Sequence

Length: 143  
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0 Synonyms

8 GO Terms

Identifier Name Description
GO:0003677 DNA binding Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
GO:0003684 damaged DNA binding Interacting selectively and non-covalently with damaged DNA.
GO:0000723 telomere maintenance Any process that contributes to the maintenance of proper telomeric length and structure by affecting and monitoring the activity of telomeric proteins and the length of telomeric DNA. These processes includes those that shorten and lengthen the telomeric DNA sequences.
GO:0004003 ATP-dependent DNA helicase activity Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction drives the unwinding of the DNA helix.
GO:0042162 telomeric DNA binding Interacting selectively and non-covalently with a telomere, a specific structure at the end of a linear chromosome required for the integrity and maintenance of the end.
GO:0006303 double-strand break repair via nonhomologous end joining The repair of a double-strand break in DNA in which the two broken ends are rejoined with little or no sequence complementarity. Information at the DNA ends may be lost due to the modification of broken DNA ends. This term covers instances of separate pathways, called classical (or canonical) and alternative nonhomologous end joining (C-NHEJ and A-NHEJ). These in turn may further branch into sub-pathways, but evidence is still unclear.
GO:0043564 Ku70:Ku80 complex Heterodimeric protein complex composed of a 70 kDa and a 80 kDa subunit, binds DNA through a channel formed by the heterodimer. Functions in DNA double stranded break repair, chromosome maintenance, transcription regulation, V(D)J recombination, and activation of DNA-PK.

21 Blast

Analysis Hit Start End Strand Length Note Hit Coverage Hit Length Hit Pident E Val Hit Description
blastp_kegg lcl|pper:PRUPE_ppa002852mg 9 142 + 134 none 21.34 628 80.60 1e-67 hypothetical protein
blastp_kegg lcl|pmum:103322539 9 142 + 134 none 21.34 628 80.60 1e-67 ATP-dependent DNA helicase 2 subunit KU70
blastp_kegg lcl|tcc:TCM_031961 9 142 + 134 none 21.34 628 79.85 2e-67 KU70 isoform 1
blastp_kegg lcl|pop:POPTR_0011s10870g 9 142 + 134 Gaps:1 21.18 628 79.70 2e-65 POPTRDRAFT_235497 Ku70-like family protein
blastp_kegg lcl|vvi:100265198 9 142 + 134 Gaps:2 21.19 623 81.82 5e-65 ATP-dependent DNA helicase 2 subunit KU70-like
blastp_kegg lcl|rcu:RCOM_0534680 9 142 + 134 Gaps:1 21.25 626 80.45 5e-65 ku P70 DNA helicase putative
blastp_kegg lcl|gmx:100775475 9 142 + 134 Gaps:1 20.98 634 79.70 2e-62 ATP-dependent DNA helicase 2 subunit KU70-like
blastp_kegg lcl|pvu:PHAVU_007G001600g 9 142 + 134 Gaps:1 21.49 619 78.95 8e-61 hypothetical protein
blastp_kegg lcl|csv:101207694 9 142 + 134 Gaps:2 21.12 625 75.76 3e-60 ATP-dependent DNA helicase 2 subunit KU70-like
blastp_kegg lcl|pop:POPTR_0011s10840g 27 142 + 116 Gaps:1 100.00 115 80.87 6e-60 hypothetical protein
blastp_pdb 1jey_A 9 140 + 132 Gaps:6 20.69 609 30.95 4e-06 mol:protein length:609 Ku70
blastp_pdb 1jeq_A 9 140 + 132 Gaps:6 20.69 609 30.95 4e-06 mol:protein length:609 KU70
blastp_uniprot_sprot sp|Q7F1M0|KU70_ORYSJ 9 142 + 134 Gaps:1 21.31 624 64.66 5e-44 ATP-dependent DNA helicase 2 subunit KU70 OS Oryza sativa subsp. japonica GN KU70 PE 1 SV 1
blastp_uniprot_sprot sp|Q9FQ08|KU70_ARATH 9 142 + 134 Gaps:8 20.29 621 65.08 6e-43 ATP-dependent DNA helicase 2 subunit KU70 OS Arabidopsis thaliana GN KU70 PE 1 SV 1
blastp_uniprot_sprot sp|Q54MA9|KU70_DICDI 9 138 + 130 Gaps:12 14.08 909 30.47 1e-07 ATP-dependent DNA helicase ku70 OS Dictyostelium discoideum GN ku70 PE 3 SV 1
blastp_uniprot_sprot sp|P23475|XRCC6_MOUSE 9 142 + 134 Gaps:8 21.05 608 32.81 1e-06 X-ray repair cross-complementing protein 6 OS Mus musculus GN Xrcc6 PE 1 SV 5
blastp_uniprot_sprot sp|O93257|XRCC6_CHICK 9 133 + 125 Gaps:12 18.83 632 32.77 8e-06 X-ray repair cross-complementing protein 5 OS Gallus gallus GN XRCC6 PE 2 SV 1
blastp_uniprot_sprot sp|Q1DU75|KU70_COCIM 9 136 + 128 Gaps:20 20.71 647 32.84 8e-06 ATP-dependent DNA helicase II subunit 1 OS Coccidioides immitis (strain RS) GN KU70 PE 3 SV 2
rpsblast_cdd gnl|CDD|129668 10 140 + 131 Gaps:6 21.40 584 34.40 3e-11 TIGR00578 ku70 ATP-dependent DNA helicase II 70 kDa subunit (ku70). Proteins in this family are involved in non-homologous end joining a process used for the repair of double stranded DNA breaks. This family is based on the phylogenomic analysis of JA Eisen (1999 Ph.D. Thesis Stanford University). Cutoff does not detect the putative ku70 homologs in yeast.
rpsblast_cdd gnl|CDD|190729 9 66 + 58 Gaps:1 62.11 95 35.59 8e-07 pfam03730 Ku_C Ku70/Ku80 C-terminal arm. The Ku heterodimer (composed of Ku70 and Ku80) contributes to genomic integrity through its ability to bind DNA double-strand breaks and facilitate repair by the non-homologous end-joining pathway. This is the C terminal arm. This alpha helical region embraces the beta-barrel domain pfam02735 of the opposite subunit.
rpsblast_kog gnl|CDD|37538 10 142 + 133 Gaps:11 21.26 602 28.91 3e-09 KOG2327 KOG2327 KOG2327 DNA-binding subunit of a DNA-dependent protein kinase (Ku70 autoantigen) [Replication recombination and repair].

9 Domain Motifs

Analysis Begin End Length Domain Identifier Cross Ref Description Inter Pro
SMART 106 140 35 SM00513 none Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation IPR003034
PANTHER 9 142 134 PTHR12604 none none none
Pfam 106 139 34 PF02037 none SAP domain IPR003034
Gene3D 96 141 46 G3DSA:1.10.720.30 none none IPR003034
Pfam 9 80 72 PF03730 "Reactome:REACT_216","Reactome:REACT_6185" Ku70/Ku80 C-terminal arm IPR005160
PANTHER 9 142 134 PTHR12604:SF2 none none IPR006165
ProSiteProfiles 106 140 35 PS50800 none SAP motif profile. IPR003034
Gene3D 9 60 52 G3DSA:1.10.1600.10 "Reactome:REACT_216","Reactome:REACT_6185" none IPR005160
SUPERFAMILY 95 140 46 SSF68906 none none none

0 Localization

16 Qtllist

Qtl Name Chromosome Name Linkage Group Prox Marker Dist Marker Position QTL Pos One Pos Two Test Type Test Value R 2
Champenoux_2015_nPriLBD_3P Qrob_Chr10 10 v_15000_157 v_15000_310 15,68 15,9 15,91 lod 2.4 5.5
Bourran2_2014_nSecLBD_3P Qrob_Chr08 8 s_1BN2OD_551 s_1B5AYF_599 17,17 0 43,51 lod 1,9229 4,4
Bourran2_2014_nLBD*_3P Qrob_Chr08 8 v_5216_549 v_11837_70 12,25 0 35,55 lod 2,5951 6
Bourran2_2014_nP*_3P Qrob_Chr08 8 v_5216_549 v_11837_70 12,19 0 31,97 lod 2,8472 6
Bourran2_2002_QTL11_peak_Bud_burst_A4 Qrob_Chr06 6 s_1C41PA_791 s_1AM1AV_1141 19,17 0 34,57 lod 2,3 2,9
Bourran2_2014_aSeqBC_3P Qrob_Chr06 6 v_506_189 v_686_77 30,72 13,58 43,48 lod 2,2746 6,3
Bourran2_2014_aSeqBC*_A4 Qrob_Chr06 6 s_2F5MK3_712 v_444_355 27,13 14,86 39,46 lod 3,7847 9,8
Bourran2_2014_nEpis*_3P Qrob_Chr08 8 s_1DA4QW_688 s_1DNI7D_820 17,96 0 37,75 lod 2,9745 7,5
Bourran2_2014_nEpis*_A4 Qrob_Chr07 7 v_12400_446 s_1BPEBU_1211 6,93 0 15,13 lod 4,7411 11
Bourran2_2014_nFork*_3P Qrob_Chr06 6 v_12930_125 s_1AMZEI_909 34,28 7,43 41,48 lod 2,4044 5,5
Bourran2_2014_nLBD_A4 Qrob_Chr06 6 v_12930_125 s_1AMZEI_909 37,41 9,8 50,1 lod 1,9524 4,1
Bourran2_2014_nPriBD_A4 Qrob_Chr06 6 v_12930_125 s_1AMZEI_909 34,51 3,36 51,86 lod 1,6747 3,9
Bourran2_2014_nSecLBD_A4 Qrob_Chr07 7 v_8327_222 s_1A4WGY_363 16,04 0 44,69 lod 2,6373 6,5
Bourran2_2014_vEpiBC_A4 Qrob_Chr06 6 v_12930_125 s_1AMZEI_909 37,55 14,41 50,01 lod 1,7882 4,8
Champenoux_2015_nEpis_3P Qrob_Chr11 11 s_1DG9PM_867 s_1BZ083_1312 26,53 25,47 27,72 lod 4.4 8.9
Champenoux_2015_nP_3P Qrob_Chr06 6 s_1A386O_228 s_1AYZFS_603 27,03 26,47 27,34 lod 2.8 7.2

0 Targeting