Protein : Qrob_P0383020.2 Q. robur
Protein Identifier  ? Qrob_P0383020.2 Organism . Name  Quercus robur
Score  96.1 Score Type  egn
Protein Description  (M=1) K08775 - breast cancer 2 susceptibility protein Gene Prediction Quality  validated
Protein length 

Sequence

Length: 1077  
Kegg Orthology  K08775
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0 Synonyms

2 GO Terms

Identifier Name Description
GO:0006281 DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway.
GO:0000724 double-strand break repair via homologous recombination The error-free repair of a double-strand break in DNA in which the broken DNA molecule is repaired using homologous sequences. A strand in the broken DNA searches for a homologous region in an intact chromosome to serve as the template for DNA synthesis. The restoration of two intact DNA molecules results in the exchange, reciprocal or nonreciprocal, of genetic material between the intact DNA molecule and the broken DNA molecule.

23 Blast

Analysis Hit Start End Strand Length Note Hit Coverage Hit Length Hit Pident E Val Hit Description
blastp_kegg lcl|vvi:100241398 1 1064 + 1064 Gaps:73 92.45 1126 64.36 0.0 uncharacterized LOC100241398
blastp_kegg lcl|rcu:RCOM_0847980 1 1069 + 1069 Gaps:51 91.18 1156 62.43 0.0 breast cancer type 2 susceptibility protein brca2 putative
blastp_kegg lcl|tcc:TCM_021601 1 1064 + 1064 Gaps:84 93.68 1155 62.01 0.0 BRCA2-like B putative isoform 2
blastp_kegg lcl|cit:102628548 1 1064 + 1064 Gaps:63 93.44 1112 62.75 0.0 uncharacterized LOC102628548
blastp_kegg lcl|cic:CICLE_v10013403mg 1 1064 + 1064 Gaps:63 93.44 1112 62.56 0.0 hypothetical protein
blastp_kegg lcl|pop:POPTR_0014s19050g 1 1064 + 1064 Gaps:136 93.93 1186 57.63 0.0 POPTRDRAFT_573323 hypothetical protein
blastp_kegg lcl|pper:PRUPE_ppa023298mg 1 1064 + 1064 Gaps:113 93.08 1099 63.15 0.0 hypothetical protein
blastp_kegg lcl|pmum:103327228 1 1064 + 1064 Gaps:118 93.37 1101 62.55 0.0 uncharacterized LOC103327228
blastp_kegg lcl|csv:101215906 1 1064 + 1064 Gaps:66 93.43 1111 58.00 0.0 uncharacterized LOC101215906
blastp_kegg lcl|csv:101230245 1 1064 + 1064 Gaps:66 93.43 1111 57.80 0.0 uncharacterized LOC101230245
blastp_pdb 1miu_A 520 940 + 421 Gaps:63 54.47 738 34.58 3e-51 mol:protein length:738 Breast Cancer type 2 susceptibility protein
blastp_pdb 1iyj_D 520 940 + 421 Gaps:63 49.20 817 33.58 5e-48 mol:protein length:817 breast cancer susceptibility
blastp_pdb 1iyj_B 520 940 + 421 Gaps:63 49.20 817 33.58 5e-48 mol:protein length:817 breast cancer susceptibility
blastp_pdb 1mje_A 520 808 + 289 Gaps:31 40.06 649 38.08 3e-38 mol:protein length:649 breast cancer 2
blastp_uniprot_sprot sp|P97929|BRCA2_MOUSE 520 940 + 421 Gaps:63 12.08 3329 34.58 3e-50 Breast cancer type 2 susceptibility protein homolog OS Mus musculus GN Brca2 PE 1 SV 2
blastp_uniprot_sprot sp|O35923|BRCA2_RAT 520 940 + 421 Gaps:63 12.03 3343 33.58 2e-47 Breast cancer type 2 susceptibility protein homolog OS Rattus norvegicus GN Brca2 PE 1 SV 1
blastp_uniprot_sprot sp|P51587|BRCA2_HUMAN 520 1042 + 523 Gaps:88 14.54 3418 32.80 5e-47 Breast cancer type 2 susceptibility protein OS Homo sapiens GN BRCA2 PE 1 SV 2
blastp_uniprot_sprot sp|Q864S8|BRCA2_FELCA 520 1022 + 503 Gaps:78 14.44 3372 31.83 2e-45 Breast cancer type 2 susceptibility protein homolog OS Felis catus GN BRCA2 PE 2 SV 2
rpsblast_cdd gnl|CDD|72966 744 980 + 237 Gaps:30 100.00 251 33.07 4e-54 cd04494 BRCA2DBD_OB2 BRCA2DBD_OB2: A subfamily of OB folds corresponding to the second OB fold (OB2) of the 800-amino acid C-terminal ssDNA binding domain (DBD) of BRCA2 (breast cancer susceptibility gene 2) protein called BRCA2DBD. BRCA2 participates in homologous recombination-mediated repair of double-strand DNA breaks. It stimulates the displacement of Replication protein A (RPA) the most abundant eukaryotic ssDNA binding protein. It also facilitates filament formation. Mutations that map throughout the BRCA2 protein are associated with breast cancer susceptibility. BRCA2 is a large nuclear protein and its most conserved region is the C-terminal BRCA2DBD. BRCA2DBD binds ssDNA in vitro and is composed of five structural domains three of which are OB folds (OB1 OB2 and OB3). BRCA2DBD OB2 and OB3 are arranged in tandem and their mode of binding can be considered qualitatively similar to two OB folds of RPA1 DBD-A and DBD-B (the major DBDs of RPA)..
rpsblast_cdd gnl|CDD|117663 581 738 + 158 Gaps:43 97.46 118 48.70 1e-31 pfam09103 BRCA-2_OB1 BRCA2 oligonucleotide/oligosaccharide-binding domain 1. Members of this family assume an OB fold which consists of a highly curved five-stranded beta-sheet that closes on itself to form a beta-barrel. OB1 has a shallow groove formed by one face of the curved sheet and is demarcated by two loops one between beta 1 and beta 2 and another between beta 4 and beta 5 which allows for weak single strand DNA binding. The domain also binds the 70-amino acid DSS1 (deleted in split-hand/split foot syndrome) protein which was originally identified as one of three genes that map to a 1.5-Mb locus deleted in an inherited developmental malformation syndrome.
rpsblast_cdd gnl|CDD|72965 593 735 + 143 Gaps:43 100.00 100 52.00 1e-25 cd04493 BRCA2DBD_OB1 BRCA2DBD_OB1: A subfamily of OB folds corresponding to the first OB fold (OB1) of the 800-amino acid C-terminal ssDNA binding domain (DBD) of BRCA2 (breast cancer susceptibility gene 2) protein called BRCA2DBD. BRCA2 participates in homologous recombination-mediated repair of double-strand DNA breaks. It stimulates the displacement of Replication protein A (RPA) the most abundant eukaryotic ssDNA binding protein. It also facilitates filament formation. Mutations that map throughout the BRCA2 protein are associated with breast cancer susceptibility. BRCA2 is a large nuclear protein and its most conserved region is the C-terminal BRCA2DBD. BRCA2DBD binds ssDNA in vitro and is composed of five structural domains three of which are OB folds (OB1 OB2 and OB3). BRCA2DBD OB2 and OB3 are arranged in tandem and their mode of binding can be considered qualitatively similar to two OB folds of RPA1 DBD-A and DBD-B (the major DBDs of RPA). BRCA2DBD OB1 binds DNA weakly..
rpsblast_cdd gnl|CDD|117723 509 576 + 68 none 34.87 195 42.65 4e-13 pfam09169 BRCA-2_helical BRCA2 helical. Members of this family adopt a helical structure consisting of a four-helix cluster core (alpha 1 alpha 8 alpha 9 alpha 10) and two successive beta-hairpins (beta 1 to beta 4). An approx. 50-amino acid segment that contains four short helices (alpha 2 to alpha 4) meanders around the surface of the core structure. In BRCA2 the alpha 9 and alpha 10 helices pack with BRCA-2_OB1 (pfam09103) through van der Waals contacts involving hydrophobic and aromatic residues and also through side-chain and backbone hydrogen bonds. The domain binds the 70-amino acid DSS1 (deleted in split-hand/split foot syndrome) protein which was originally identified as one of three genes that map to a 1.5-Mb locus deleted in an inherited developmental malformation syndrome.
rpsblast_kog gnl|CDD|39948 54 1068 + 1015 Gaps:117 97.75 756 40.87 1e-103 KOG4751 KOG4751 KOG4751 DNA recombinational repair protein BRCA2 [Replication recombination and repair].

19 Domain Motifs

Analysis Begin End Length Domain Identifier Cross Ref Description Inter Pro
ProSiteProfiles 96 130 35 PS50138 none BRCA2 repeat profile. IPR002093
PANTHER 55 680 626 PTHR11289:SF0 none none none
Pfam 502 576 75 PF09169 none BRCA2, helical IPR015252
Gene3D 888 966 79 G3DSA:2.40.50.140 none none IPR012340
Gene3D 743 770 28 G3DSA:2.40.50.140 none none IPR012340
Pfam 581 685 105 PF09103 none BRCA2, oligonucleotide/oligosaccharide-binding, domain 1 IPR015187
SUPERFAMILY 742 771 30 SSF50249 none none IPR012340
SUPERFAMILY 890 974 85 SSF50249 none none IPR012340
ProSiteProfiles 211 245 35 PS50138 none BRCA2 repeat profile. IPR002093
SUPERFAMILY 772 890 119 SSF81878 none none none
PANTHER 711 1042 332 PTHR11289 none none IPR015525
PANTHER 711 1042 332 PTHR11289:SF0 none none none
SUPERFAMILY 581 689 109 SSF50249 none none IPR012340
PANTHER 55 680 626 PTHR11289 none none IPR015525
SUPERFAMILY 450 579 130 SSF81872 none none IPR015252
Pfam 54 80 27 PF00634 none BRCA2 repeat IPR002093
Pfam 98 130 33 PF00634 none BRCA2 repeat IPR002093
Pfam 213 244 32 PF00634 none BRCA2 repeat IPR002093
Gene3D 580 737 158 G3DSA:2.40.50.140 none none IPR012340

0 Localization

5 Qtllist

Qtl Name Chromosome Name Linkage Group Prox Marker Dist Marker Position QTL Pos One Pos Two Test Type Test Value R 2
Bourran2_2014_nSecLBD_A4 Qrob_Chr07 7 v_8327_222 s_1A4WGY_363 16,04 0 44,69 lod 2,6373 6,5
Bourran2_2014_nP_A4 Qrob_Chr11 11 s_1B58GB_1413 s_1A5BYY_1671 11,15 0 42,38 lod 1,8913 4,5
Bourran2_2015_nSeqBC_3P Qrob_Chr11 11 s_1DG9PM_867 s_1BZ083_1312 26,06 25,47 27,72 lod 3.6 7.1
Bourran2_2015_nEpis_A4 Qrob_Chr09 9 v_15847_485 v_8329_369 34,94 34,88 37,45 lod 3.1 7
Bourran2_2015_nEpiBC_A4 Qrob_Chr07 7 s_1DP9TW_798 v_8128_173 22,61 22,14 22,73 lod 3.1 8.5

0 Targeting