| Analysis | rpsblast_cdd | Start | 593 |
| End | 735 | Strand | + |
| Length | 143 | Note | Gaps:43 |
| Hit Coverage | 100.00 | Hit Length | 100 |
| Hit Pident | 52.00 | E Val | 1e-25 |
| Hit Description | cd04493 BRCA2DBD_OB1 BRCA2DBD_OB1: A subfamily of OB folds corresponding to the first OB fold (OB1) of the 800-amino acid C-terminal ssDNA binding domain (DBD) of BRCA2 (breast cancer susceptibility gene 2) protein called BRCA2DBD. BRCA2 participates in homologous recombination-mediated repair of double-strand DNA breaks. It stimulates the displacement of Replication protein A (RPA) the most abundant eukaryotic ssDNA binding protein. It also facilitates filament formation. Mutations that map throughout the BRCA2 protein are associated with breast cancer susceptibility. BRCA2 is a large nuclear protein and its most conserved region is the C-terminal BRCA2DBD. BRCA2DBD binds ssDNA in vitro and is composed of five structural domains three of which are OB folds (OB1 OB2 and OB3). BRCA2DBD OB2 and OB3 are arranged in tandem and their mode of binding can be considered qualitatively similar to two OB folds of RPA1 DBD-A and DBD-B (the major DBDs of RPA). BRCA2DBD OB1 binds DNA weakly.. | Hit Pcons | 9.00 |
| Name | Qrob_P0383020.2 |
| Protein Identifier |
Organism . Name |
Score | Score Type | Protein Description | Alias (in v1) | Code Enzyme | Gene Prediction Quality |
|---|---|---|---|---|---|---|---|
| Qrob_P0383020.2 | Quercus robur | 96.1 | egn | (M=1) K08775 - breast cancer 2 susceptibility protein | validated |
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