Protein : Qrob_P0196000.2 Q. robur
Protein Identifier  ? Qrob_P0196000.2 Organism . Name  Quercus robur
Score  0.0 Score Type  egn
Protein Description  (M=2) KOG0202//KOG0204//KOG0206//KOG0208//KOG0209//KOG0210 - Ca2+ transporting ATPase [Inorganic ion transport and metabolism]. // Calcium transporting ATPase [Inorganic ion transport and metabolism]. // P-type ATPase [General function prediction only]. // Cation transport ATPase [Inorganic ion transport and metabolism]. // P-type ATPase [Inorganic ion transport and metabolism]. // P-type ATPase [Inorganic ion transport and metabolism]. Code Enzyme  EC:3.6.3.1
Gene Prediction Quality  validated Protein length 

Sequence

Length: 538  
Kegg Orthology  K01530
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0 Synonyms

6 GO Terms

Identifier Name Description
GO:0005524 ATP binding Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
GO:0016021 integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
GO:0000166 nucleotide binding Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose.
GO:0000287 magnesium ion binding Interacting selectively and non-covalently with magnesium (Mg) ions.
GO:0004012 phospholipid-translocating ATPase activity Catalysis of the movement of phospholipids from one membrane bilayer leaflet to the other, driven by the hydrolysis of ATP.
GO:0015914 phospholipid transport The directed movement of phospholipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Phospholipids are any lipids containing phosphoric acid as a mono- or diester.

34 Blast

Analysis Hit Start End Strand Length Note Hit Coverage Hit Length Hit Pident E Val Hit Description
blastp_kegg lcl|gmx:100779714 48 535 + 488 Gaps:121 51.22 1189 59.93 0.0 putative phospholipid-transporting ATPase 8-like
blastp_kegg lcl|gmx:100817020 48 535 + 488 Gaps:126 51.42 1194 59.61 0.0 putative phospholipid-transporting ATPase 8-like
blastp_kegg lcl|mdm:103421610 46 535 + 490 Gaps:119 95.31 639 57.64 0.0 putative phospholipid-transporting ATPase 8
blastp_kegg lcl|mtr:MTR_6g006910 48 535 + 488 Gaps:124 51.30 1193 57.03 0.0 ATPase
blastp_kegg lcl|rcu:RCOM_1095380 46 536 + 491 Gaps:120 51.40 1181 57.83 0.0 Phospholipid-transporting ATPase putative (EC:3.6.3.1)
blastp_kegg lcl|pxb:103965848 48 537 + 490 Gaps:121 51.26 1192 57.94 0.0 putative phospholipid-transporting ATPase 8
blastp_kegg lcl|pxb:103963957 48 537 + 490 Gaps:121 51.26 1192 57.94 0.0 putative phospholipid-transporting ATPase 8
blastp_kegg lcl|cam:101498223 48 535 + 488 Gaps:124 51.17 1196 57.52 0.0 putative phospholipid-transporting ATPase 8-like
blastp_kegg lcl|mdm:103404324 48 537 + 490 Gaps:121 51.26 1192 57.28 0.0 putative phospholipid-transporting ATPase 8
blastp_kegg lcl|tcc:TCM_016891 48 517 + 470 Gaps:118 49.12 1197 56.97 0.0 ATPase E1-E2 type family protein / haloacid dehalogenase-like hydrolase family protein
blastp_uniprot_sprot sp|Q9LK90|ALA8_ARATH 54 537 + 484 Gaps:125 51.22 1189 55.67 0.0 Putative phospholipid-transporting ATPase 8 OS Arabidopsis thaliana GN ALA8 PE 3 SV 1
blastp_uniprot_sprot sp|Q9SX33|ALA9_ARATH 48 512 + 465 Gaps:116 48.08 1200 48.35 2e-170 Putative phospholipid-transporting ATPase 9 OS Arabidopsis thaliana GN ALA9 PE 3 SV 1
blastp_uniprot_sprot sp|Q9LI83|ALA10_ARATH 48 525 + 478 Gaps:115 49.33 1202 47.89 5e-164 Phospholipid-transporting ATPase 10 OS Arabidopsis thaliana GN ALA10 PE 1 SV 1
blastp_uniprot_sprot sp|Q9SAF5|ALA11_ARATH 47 525 + 479 Gaps:117 49.54 1203 47.15 3e-161 Putative phospholipid-transporting ATPase 11 OS Arabidopsis thaliana GN ALA11 PE 2 SV 1
blastp_uniprot_sprot sp|P57792|ALA12_ARATH 54 511 + 458 Gaps:113 48.06 1184 46.57 1e-153 Putative phospholipid-transporting ATPase 12 OS Arabidopsis thaliana GN ALA12 PE 2 SV 1
blastp_uniprot_sprot sp|Q9SLK6|ALA6_ARATH 47 525 + 479 Gaps:65 42.26 1240 47.52 6e-73 Phospholipid-transporting ATPase 6 OS Arabidopsis thaliana GN ALA6 PE 1 SV 2
blastp_uniprot_sprot sp|Q9LVK9|ALA7_ARATH 48 506 + 459 Gaps:63 40.39 1243 47.61 8e-73 Putative phospholipid-transporting ATPase 7 OS Arabidopsis thaliana GN ALA7 PE 3 SV 3
blastp_uniprot_sprot sp|Q9LNQ4|ALA4_ARATH 48 506 + 459 Gaps:64 41.20 1216 48.10 8e-71 Putative phospholipid-transporting ATPase 4 OS Arabidopsis thaliana GN ALA4 PE 1 SV 2
blastp_uniprot_sprot sp|Q9SGG3|ALA5_ARATH 48 525 + 478 Gaps:65 42.59 1228 46.46 4e-70 Putative phospholipid-transporting ATPase 5 OS Arabidopsis thaliana GN ALA5 PE 3 SV 1
blastp_uniprot_sprot sp|P98198|AT8B2_HUMAN 49 535 + 487 Gaps:136 49.21 1209 29.92 4e-63 Probable phospholipid-transporting ATPase ID OS Homo sapiens GN ATP8B2 PE 2 SV 2
rpsblast_cdd gnl|CDD|200120 49 506 + 458 Gaps:71 46.45 1057 43.58 3e-78 TIGR01652 ATPase-Plipid phospholipid-translocating P-type ATPase flippase. This model describes the P-type ATPase responsible for transporting phospholipids from one leaflet of bilayer membranes to the other. These ATPases are found only in eukaryotes.
rpsblast_cdd gnl|CDD|178732 55 521 + 467 Gaps:173 49.07 1178 28.72 4e-49 PLN03190 PLN03190 aminophospholipid translocase Provisional.
rpsblast_cdd gnl|CDD|30822 48 484 + 437 Gaps:118 51.15 917 23.88 2e-40 COG0474 MgtA Cation transport ATPase [Inorganic ion transport and metabolism].
rpsblast_cdd gnl|CDD|211660 52 305 + 254 Gaps:91 32.01 528 34.91 7e-16 TIGR01494 ATPase_P-type ATPase P-type (transporting) HAD superfamily subfamily IC. The P-type ATPases are a large family of trans-membrane transporters acting on charged substances. The distinguishing feature of the family is the formation of a phosphorylated intermediate (aspartyl-phosphate) during the course of the reaction. Another common name for these enzymes is the E1-E2 ATPases based on the two isolable conformations: E1 (unphosphorylated) and E2 (phosphorylated). Generally P-type ATPases consist of only a single subunit encompassing the ATPase and ion translocation pathway however in the case of the potassium (TIGR01497) and sodium/potassium (TIGR01106) varieties these functions are split between two subunits. Additional small regulatory or stabilizing subunits may also exist in some forms. P-type ATPases are nearly ubiquitous in life and are found in numerous copies in higher organisms (at least 45 in Arabidopsis thaliana for instance). Phylogenetic analyses have revealed that the P-type ATPase subfamily is divided up into groups based on substrate specificities and this is represented in the various subfamily and equivalog models that have been made: IA (K+) TIGR01497 IB (heavy metals) TIGR01525 IIA1 (SERCA-type Ca++) TIGR01116 IIA2 (PMR1-type Ca++) TIGR01522 IIB (PMCA-type Ca++) TIGR01517 IIC (Na+/K+ H+/K+ antiporters) TIGR01106 IID (fungal-type Na+ and K+) TIGR01523 IIIA (H+) TIGR01647 IIIB (Mg++) TIGR01524 IV (phospholipid flippase) TIGR01652 and V (unknown specificity) TIGR01657. The crystal structure of one calcium-pumping ATPase and an analysis of the fold of the catalytic domain of the P-type ATPases have been published. These reveal that the catalytic core of these enzymes is a haloacid dehalogenase(HAD)-type aspartate-nucleophile hydrolase. The location of the ATP-binding loop in between the first and second HAD conserved catalytic motifs defines these enzymes as members of subfamily I of the HAD superfamily (see also TIGR01493 TIGR01509 TIGR01549 TIGR01544 and TIGR01545). Based on these classifications the P-type ATPase _superfamily_ corresponds to the IC subfamily of the HAD superfamily.
rpsblast_cdd gnl|CDD|162469 47 304 + 258 Gaps:50 26.57 1054 23.57 1e-13 TIGR01657 P-ATPase-V P-type ATPase of unknown pump specificity (type V). These P-type ATPases form a distinct clade but the substrate of their pumping activity has yet to be determined. This clade has been designated type V in.
rpsblast_cdd gnl|CDD|188151 55 303 + 249 Gaps:56 23.41 944 30.77 5e-09 TIGR01517 ATPase-IIB_Ca plasma-membrane calcium-translocating P-type ATPase. This model describes the P-type ATPase responsible for translocating calcium ions across the plasma membrane of eukaryotes out of the cell. In some organisms this type of pump may also be found in vacuolar membranes. In humans and mice at least there are multiple isoforms of the PMCA pump with overlapping but not redundant functions. Accordingly there are no human diseases linked to PMCA defects although alterations of PMCA function do elicit physiological effects. The calcium P-type ATPases have been characterized as Type IIB based on a phylogenetic analysis which distinguishes this group from the Type IIA SERCA calcium pump. A separate analysis divides Type IIA into sub-types (SERCA and PMR1) which are modelled by two corresponding families (TIGR01116 and TIGR01522). This model is well separated from those.
rpsblast_cdd gnl|CDD|205426 53 97 + 45 Gaps:1 50.55 91 32.61 7e-08 pfam13246 Hydrolase_like2 Putative hydrolase of sodium-potassium ATPase alpha subunit. This is a putative hydrolase of the sodium-potassium ATPase alpha subunit.
rpsblast_cdd gnl|CDD|200073 53 304 + 252 Gaps:61 25.63 917 30.64 4e-07 TIGR01116 ATPase-IIA1_Ca sarco/endoplasmic reticulum calcium-translocating P-type ATPase. This model describes the P-type ATPase responsible for translocating calcium ions across the endoplasmic reticulum membrane of eukaryotes and is of particular importance in the sarcoplasmic reticulum of skeletal and cardiac muscle in vertebrates. These pumps transfer Ca2+ from the cytoplasm to the lumen of the endoplasmic reticulum. In humans and mice at least there are multiple isoforms of the SERCA pump with overlapping but not redundant functions. Defects in SERCA isoforms are associated with diseases in humans. The calcium P-type ATPases have been characterized as Type IIA based on a phylogenetic analysis which distinguishes this group from the Type IIB PMCA calcium pump modelled by TIGR01517. A separate analysis divides Type IIA into sub-types SERCA and PMR1 the latter of which is modelled by TIGR01522.
rpsblast_kog gnl|CDD|35427 46 507 + 462 Gaps:63 43.79 1151 44.25 1e-78 KOG0206 KOG0206 KOG0206 P-type ATPase [General function prediction only].
rpsblast_kog gnl|CDD|35431 48 305 + 258 Gaps:61 25.98 1051 35.53 7e-32 KOG0210 KOG0210 KOG0210 P-type ATPase [Inorganic ion transport and metabolism].

21 Domain Motifs

Analysis Begin End Length Domain Identifier Cross Ref Description Inter Pro
Phobius 451 469 19 NON_CYTOPLASMIC_DOMAIN none Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region. none
Phobius 363 381 19 TRANSMEMBRANE none Region of a membrane-bound protein predicted to be embedded in the membrane. none
Phobius 470 490 21 TRANSMEMBRANE none Region of a membrane-bound protein predicted to be embedded in the membrane. none
PANTHER 54 506 453 PTHR24092 none none IPR006539
Phobius 425 430 6 CYTOPLASMIC_DOMAIN none Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm. none
Phobius 401 424 24 TRANSMEMBRANE none Region of a membrane-bound protein predicted to be embedded in the membrane. none
Gene3D 257 306 50 G3DSA:3.40.50.1000 none none IPR023214
Gene3D 174 224 51 G3DSA:3.40.50.1000 none none IPR023214
Phobius 321 342 22 TRANSMEMBRANE none Region of a membrane-bound protein predicted to be embedded in the membrane. none
Phobius 382 400 19 NON_CYTOPLASMIC_DOMAIN none Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region. none
SUPERFAMILY 53 159 107 SSF81660 none none IPR023299
Phobius 491 537 47 CYTOPLASMIC_DOMAIN none Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm. none
SUPERFAMILY 312 499 188 SSF81665 none none none
Pfam 53 97 45 PF13246 none Putative hydrolase of sodium-potassium ATPase alpha subunit none
Phobius 1 320 320 NON_CYTOPLASMIC_DOMAIN none Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region. none
Phobius 431 450 20 TRANSMEMBRANE none Region of a membrane-bound protein predicted to be embedded in the membrane. none
Coils 204 225 22 Coil none none none
Phobius 343 362 20 CYTOPLASMIC_DOMAIN none Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm. none
SUPERFAMILY 140 306 167 SSF56784 none none IPR023214
Gene3D 52 152 101 G3DSA:3.40.1110.10 none none IPR023299
PANTHER 54 506 453 PTHR24092:SF53 none none none

5 Localization

Analysis Start End Length
TMHMM 321 340 19
TMHMM 402 424 22
TMHMM 360 382 22
TMHMM 431 450 19
TMHMM 470 490 20

1 Qtllist

Qtl Name Chromosome Name Linkage Group Prox Marker Dist Marker Position QTL Pos One Pos Two Test Type Test Value R 2
Bourran1_2003_QTL2_peak_Bud_burst_A4 Qrob_Chr02 2 s_1B0H8U_259 s_1CB1VL_554 17 0 87 lod 3,3 8,7

0 Targeting