Protein : Qrob_P0189210.2 Q. robur
Protein Identifier  ? Qrob_P0189210.2 Organism . Name  Quercus robur
Score  67.3 Score Type  egn
Protein Description  (M=4) PTHR11390:SF23 - DNA TOPOISOMERASE I-RELATED Code Enzyme  EC:5.99.1.2
Gene Prediction Quality  validated Protein length 

Sequence

Length: 73  
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0 Synonyms

4 GO Terms

Identifier Name Description
GO:0003677 DNA binding Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
GO:0006265 DNA topological change The process in which a transformation is induced in the topological structure of a double-stranded DNA helix, resulting in a change in linking number.
GO:0003917 DNA topoisomerase type I activity Catalysis of a DNA topological transformation by transiently cleaving one DNA strand at a time to allow passage of another strand; changes the linking number by +1 per catalytic cycle.
GO:0003916 DNA topoisomerase activity Catalysis of the transient cleavage and passage of individual DNA strands or double helices through one another, resulting a topological transformation in double-stranded DNA.

25 Blast

Analysis Hit Start End Strand Length Note Hit Coverage Hit Length Hit Pident E Val Hit Description
blastp_kegg lcl|pper:PRUPE_ppa020488mg 8 72 + 65 none 11.99 542 96.92 2e-37 hypothetical protein
blastp_kegg lcl|pmum:103327049 8 72 + 65 none 7.14 910 96.92 3e-37 DNA topoisomerase 3-alpha
blastp_kegg lcl|csv:101224272 2 72 + 71 none 11.70 607 88.73 6e-37 DNA topoisomerase 3-like
blastp_kegg lcl|csv:101209351 2 72 + 71 none 7.68 925 88.73 7e-37 TOP3A topoisomerase (DNA) III alpha
blastp_kegg lcl|pxb:103946776 8 72 + 65 none 6.69 972 96.92 1e-36 DNA topoisomerase 3-alpha
blastp_kegg lcl|cmo:103486821 2 72 + 71 none 7.57 938 87.32 5e-36 DNA topoisomerase 3-alpha
blastp_kegg lcl|fve:101293143 8 72 + 65 none 7.16 908 92.31 4e-35 DNA topoisomerase 3-alpha-like
blastp_kegg lcl|mus:103986661 8 72 + 65 none 7.07 920 93.85 6e-35 DNA topoisomerase 3-alpha
blastp_kegg lcl|vvi:100248256 8 72 + 65 none 7.11 914 92.31 8e-35 DNA topoisomerase 3-alpha-like
blastp_kegg lcl|cam:101494498 8 72 + 65 none 7.07 920 90.77 2e-34 DNA topoisomerase 3-alpha-like
blastp_uniprot_sprot sp|Q8T2T7|TOP3_DICDI 8 72 + 65 none 7.85 828 46.15 2e-12 DNA topoisomerase 3 OS Dictyostelium discoideum GN top3 PE 3 SV 1
blastp_uniprot_sprot sp|O70157|TOP3A_MOUSE 1 72 + 72 none 7.18 1003 43.06 6e-12 DNA topoisomerase 3-alpha OS Mus musculus GN Top3a PE 2 SV 1
blastp_uniprot_sprot sp|Q13472|TOP3A_HUMAN 1 72 + 72 none 7.19 1001 41.67 3e-11 DNA topoisomerase 3-alpha OS Homo sapiens GN TOP3A PE 1 SV 1
blastp_uniprot_sprot sp|Q9NG98|TOP3A_DROME 8 58 + 51 none 4.08 1250 52.94 1e-10 DNA topoisomerase 3-alpha OS Drosophila melanogaster GN Top3alpha PE 2 SV 2
blastp_uniprot_sprot sp|Q9Z321|TOP3B_MOUSE 7 72 + 66 none 7.66 862 42.42 1e-09 DNA topoisomerase 3-beta-1 OS Mus musculus GN Top3b PE 2 SV 1
blastp_uniprot_sprot sp|O95985|TOP3B_HUMAN 20 72 + 53 none 6.15 862 49.06 2e-09 DNA topoisomerase 3-beta-1 OS Homo sapiens GN TOP3B PE 2 SV 1
blastp_uniprot_sprot sp|O61660|TOP3_CAEEL 8 72 + 65 none 8.56 759 43.08 3e-08 DNA topoisomerase 3 OS Caenorhabditis elegans GN top-3 PE 2 SV 1
blastp_uniprot_sprot sp|O60126|TOP3_SCHPO 8 61 + 54 none 8.68 622 42.59 8e-07 DNA topoisomerase 3 OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN top3 PE 1 SV 2
blastp_uniprot_sprot sp|P13099|TOP3_YEAST 15 72 + 58 Gaps:3 9.30 656 37.70 6e-06 DNA topoisomerase 3 OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN TOP3 PE 1 SV 1
rpsblast_cdd gnl|CDD|73184 7 72 + 66 Gaps:1 17.06 381 36.92 3e-16 cd00186 TOP1Ac DNA Topoisomerase subtype IA DNA-binding ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA and then rejoin the broken phosphodiester backbone. Proposed catalytic mechanism of single stranded DNA cleavage is by phosphoryl transfer through a tyrosine nucleophile using acid/base catalysis. Tyr is activated by a nearby group (not yet identified) acting as a general base for nucleophilic attack on the 5' phosphate of the scissile bond. Arg and Lys stabilize the pentavalent transition state. Glu then acts as a proton donor for the leaving 3'-oxygen upon cleavage of the scissile strand..
rpsblast_cdd gnl|CDD|201614 7 72 + 66 none 18.08 365 36.36 2e-15 pfam01131 Topoisom_bac DNA topoisomerase. This subfamily of topoisomerase is divided on the basis that these enzymes preferentially relax negatively supercoiled DNA from a 5' phospho- tyrosine linkage in the enzyme-DNA covalent intermediate and has high affinity for single stranded DNA.
rpsblast_cdd gnl|CDD|197725 7 72 + 66 Gaps:1 25.10 259 35.38 3e-15 smart00437 TOP1Ac Bacterial DNA topoisomerase I DNA-binding domain. Bacterial DNA topoisomerase I and III Eukaryotic DNA topoisomeraes III reverse gyrase alpha subunit.
rpsblast_cdd gnl|CDD|30896 13 72 + 60 Gaps:1 10.35 570 40.68 2e-13 COG0550 TopA Topoisomerase IA [DNA replication recombination and repair].
rpsblast_cdd gnl|CDD|180891 11 72 + 62 Gaps:2 7.30 822 36.67 3e-10 PRK07219 PRK07219 DNA topoisomerase I Validated.
rpsblast_kog gnl|CDD|37167 8 72 + 65 Gaps:1 8.71 758 51.52 2e-21 KOG1956 KOG1956 KOG1956 DNA topoisomerase III alpha [Replication recombination and repair].

5 Domain Motifs

Analysis Begin End Length Domain Identifier Cross Ref Description Inter Pro
PANTHER 7 72 66 PTHR11390:SF23 none none none
Gene3D 10 71 62 G3DSA:1.10.460.10 none none IPR013824
SUPERFAMILY 8 71 64 SSF56712 none none IPR023405
Pfam 11 72 62 PF01131 none DNA topoisomerase IPR013497
PANTHER 7 72 66 PTHR11390 none none IPR000380

0 Localization

2 Qtllist

Qtl Name Chromosome Name Linkage Group Prox Marker Dist Marker Position QTL Pos One Pos Two Test Type Test Value R 2
Bourran2_2002_QTL13_peak_Bud_burst_3P Qrob_Chr10 10 s_1B1AG7_637 s_1A3A1N_709 19,44 0 49,44 lod 3 5,6
Champenoux_2015_nPriLBD_3P Qrob_Chr10 10 v_15000_157 v_15000_310 15,68 15,9 15,91 lod 2.4 5.5

0 Targeting