Protein : Qrob_P0120240.2 Q. robur
Protein Identifier  ? Qrob_P0120240.2 Organism . Name  Quercus robur
Score  100.0 Score Type  egn
Protein Description  (M=1) K12591 - exosome complex exonuclease RRP6 [EC:3.1.13.-] Gene Prediction Quality  validated
Protein length 

Sequence

Length: 424  
Kegg Orthology  K12591
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0 Synonyms

5 GO Terms

Identifier Name Description
GO:0006396 RNA processing Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules.
GO:0003676 nucleic acid binding Interacting selectively and non-covalently with any nucleic acid.
GO:0006139 nucleobase-containing compound metabolic process Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids.
GO:0008408 3'-5' exonuclease activity Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' end.
GO:0000176 nuclear exosome (RNase complex) Complex of 3'-5' exoribonucleases found in the nucleus.

33 Blast

Analysis Hit Start End Strand Length Note Hit Coverage Hit Length Hit Pident E Val Hit Description
blastp_kegg lcl|pper:PRUPE_ppa001105mg 23 405 + 383 Gaps:52 44.82 908 64.62 1e-170 hypothetical protein
blastp_kegg lcl|pmum:103342295 35 405 + 371 Gaps:52 42.98 919 65.06 5e-166 uncharacterized LOC103342295
blastp_kegg lcl|mdm:103430914 35 399 + 365 Gaps:56 45.28 868 64.38 1e-159 exosome component 10-like
blastp_kegg lcl|pxb:103944375 35 399 + 365 Gaps:56 43.00 914 63.61 5e-158 exosome component 10
blastp_kegg lcl|pda:103719935 23 368 + 346 Gaps:42 47.15 772 64.56 2e-157 exosome component 10-like
blastp_kegg lcl|csv:101223669 11 403 + 393 Gaps:64 42.89 935 64.34 2e-157 exosome component 10-like
blastp_kegg lcl|csv:101220390 11 403 + 393 Gaps:64 42.84 936 64.34 2e-157 exosome component 10-like
blastp_kegg lcl|cmo:103485997 11 403 + 393 Gaps:65 42.86 938 63.93 7e-157 exosome component 10
blastp_kegg lcl|mdm:103449428 35 399 + 365 Gaps:55 43.15 913 63.71 5e-153 exosome component 10-like
blastp_kegg lcl|gmx:100819332 20 368 + 349 Gaps:47 41.28 877 67.96 2e-152 exosome component 10-like
blastp_pdb 3sah_B 190 403 + 214 Gaps:16 46.73 428 47.50 9e-46 mol:protein length:428 Exosome component 10
blastp_pdb 3sah_A 190 403 + 214 Gaps:16 46.73 428 47.50 9e-46 mol:protein length:428 Exosome component 10
blastp_pdb 3sag_B 190 403 + 214 Gaps:16 46.73 428 47.00 5e-45 mol:protein length:428 Exosome component 10
blastp_pdb 3sag_A 190 403 + 214 Gaps:16 46.73 428 47.00 5e-45 mol:protein length:428 Exosome component 10
blastp_pdb 3saf_B 190 403 + 214 Gaps:16 46.73 428 47.00 5e-45 mol:protein length:428 Exosome component 10
blastp_pdb 3saf_A 190 403 + 214 Gaps:16 46.73 428 47.00 5e-45 mol:protein length:428 Exosome component 10
blastp_pdb 2hbm_A 240 368 + 129 Gaps:5 31.22 410 52.34 1e-34 mol:protein length:410 Exosome complex exonuclease RRP6
blastp_pdb 2hbl_A 240 368 + 129 Gaps:5 31.22 410 52.34 1e-34 mol:protein length:410 Exosome complex exonuclease RRP6
blastp_pdb 2hbk_A 240 368 + 129 Gaps:5 31.22 410 52.34 1e-34 mol:protein length:410 Exosome complex exonuclease RRP6
blastp_pdb 2hbj_A 240 368 + 129 Gaps:5 31.22 410 52.34 1e-34 mol:protein length:410 Exosome complex exonuclease RRP6
blastp_uniprot_sprot sp|P56960|EXOSX_MOUSE 94 403 + 310 Gaps:74 37.88 887 37.20 1e-47 Exosome component 10 OS Mus musculus GN Exosc10 PE 1 SV 2
blastp_uniprot_sprot sp|Q01780|EXOSX_HUMAN 94 403 + 310 Gaps:74 37.97 885 36.90 4e-47 Exosome component 10 OS Homo sapiens GN EXOSC10 PE 1 SV 2
blastp_uniprot_sprot sp|Q12149|RRP6_YEAST 39 368 + 330 Gaps:30 43.66 733 32.19 2e-36 Exosome complex exonuclease RRP6 OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN RRP6 PE 1 SV 1
blastp_uniprot_sprot sp|Q10146|RRP6_SCHPO 140 367 + 228 Gaps:23 31.79 777 37.25 4e-32 Exosome complex exonuclease rrp6 OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN rrp6 PE 3 SV 2
rpsblast_cdd gnl|CDD|99850 233 398 + 166 Gaps:15 78.65 192 56.95 2e-63 cd06147 Rrp6p_like_exo DEDDy 3'-5' exonuclease domain of yeast Rrp6p human polymyositis/scleroderma autoantigen 100kDa and similar proteins. Yeast Rrp6p and its human homolog the polymyositis/scleroderma autoantigen 100kDa (PM/Scl-100) are exosome-associated proteins involved in the degradation and processing of precursors to stable RNAs. Both proteins contain a DEDDy-type DnaQ-like 3'-5' exonuclease domain possessing three conserved sequence motifs termed ExoI ExoII and ExoIII with a specific YX(3)D pattern at ExoIII. The motifs are clustered around the active site and contain four conserved acidic residues that serve as ligands for the two metal ions required for catalysis. PM/Scl-100 an autoantigen present in the nucleolar compartment of the cell reacts with autoantibodies produced by about 50% of patients with polymyositis-scleroderma overlap syndrome.
rpsblast_cdd gnl|CDD|201888 245 399 + 155 Gaps:18 83.14 172 34.97 3e-28 pfam01612 DNA_pol_A_exo1 3'-5' exonuclease. This domain is responsible for the 3'-5' exonuclease proofreading activity of E. coli DNA polymerase I (polI) and other enzymes it catalyzes the hydrolysis of unpaired or mismatched nucleotides. This domain consists of the amino-terminal half of the Klenow fragment in E. coli polI it is also found in the Werner syndrome helicase (WRN) focus forming activity 1 protein (FFA-1) and ribonuclease D (RNase D). Werner syndrome is a human genetic disorder causing premature aging the WRN protein has helicase activity in the 3'-5' direction. The FFA-1 protein is required for formation of a replication foci and also has helicase activity it is a homologue of the WRN protein. RNase D is a 3'-5' exonuclease involved in tRNA processing. Also found in this family is the autoantigen PM/Scl thought to be involved in polymyositis-scleroderma overlap syndrome.
rpsblast_cdd gnl|CDD|176654 245 392 + 148 Gaps:17 74.72 178 38.35 9e-24 cd06142 RNaseD_exo DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins. Ribonuclease (RNase) D is a bacterial enzyme involved in the maturation of small stable RNAs and the 3' maturation of tRNA. It contains a DEDDy-type DnaQ-like 3'-5' exonuclease domain possessing three conserved sequence motifs termed ExoI ExoII and ExoIII with a specific YX(3)D pattern at ExoIII. These motifs are clustered around the active site and contain four conserved acidic residues that serve as ligands for the two metal ions required for catalysis. In vivo RNase D only becomes essential upon removal of other ribonucleases. Eukaryotic RNase D homologs include yeast Rrp6p human PM/Scl-100 and the Drosophila melanogaster egalitarian protein.
rpsblast_cdd gnl|CDD|197748 237 400 + 164 Gaps:20 88.37 172 34.21 2e-19 smart00474 35EXOc 3'-5' exonuclease. 3\' -5' exonuclease proofreading domain present in DNA polymerase I Werner syndrome helicase RNase D and other enzymes.
rpsblast_cdd gnl|CDD|176650 258 368 + 111 Gaps:3 69.57 161 32.14 4e-18 cd06129 RNaseD_like DEDDy 3'-5' exonuclease domain of RNase D WRN and similar proteins. The RNase D-like group is composed of RNase D WRN and similar proteins. They contain a DEDDy-type DnaQ-like 3'-5' exonuclease domain that contains three conserved sequence motifs termed ExoI ExoII and ExoIII with a specific YX(3)D pattern at ExoIII. These motifs are clustered around the active site and contain four conserved acidic residues that serve as ligands for the two metal ions required for catalysis. RNase D is involved in the 3'-end processing of tRNA precursors. RNase D-like proteins in eukaryotes include yeast Rrp6p human PM/Scl-100 and Drosophila melanogaster egalitarian (Egl) protein. WRN is a unique DNA helicase possessing exonuclease activity. Mutation in the WRN gene is implicated in Werner syndrome a disease associated with premature aging and increased predisposition to cancer. Yeast Rrp6p and the human Polymyositis/scleroderma autoantigen 100kDa (PM/Scl-100) are exosome-associated proteins involved in the degradation and processing of precursors to stable RNAs. Egl is a component of an mRNA-binding complex which is required for oocyte specification. The Egl subfamily does not possess a completely conserved YX(3)D pattern at the ExoIII motif.
rpsblast_cdd gnl|CDD|30697 240 367 + 128 Gaps:2 35.46 361 30.47 1e-16 COG0349 Rnd Ribonuclease D [Translation ribosomal structure and biogenesis].

8 Domain Motifs

Analysis Begin End Length Domain Identifier Cross Ref Description Inter Pro
PANTHER 1 366 366 PTHR12124 none none none
Pfam 240 368 129 PF01612 none 3'-5' exonuclease IPR002562
SMART 237 399 163 SM00474 none 3'-5' exonuclease IPR002562
Coils 10 31 22 Coil none none none
SUPERFAMILY 168 369 202 SSF53098 none none IPR012337
Gene3D 237 354 118 G3DSA:3.30.420.10 none none IPR012337
PANTHER 1 366 366 PTHR12124:SF42 none none none
Pfam 33 122 90 PF08066 none PMC2NT (NUC016) domain IPR012588

0 Localization

13 Qtllist

Qtl Name Chromosome Name Linkage Group Prox Marker Dist Marker Position QTL Pos One Pos Two Test Type Test Value R 2
Bourran2_2014_nLBD*_A4 Qrob_Chr08 8 v_12498_318 v_12364_308 34,91 16,12 53,62 lod 2,4961 5,2
Bourran2_2014_nPriLBD_3P Qrob_Chr08 8 v_5216_549 v_11837_70 12,36 0 30,43 lod 2,5806 5,1
Bourran2_2014_nEpis*_A4 Qrob_Chr07 7 v_12400_446 s_1BPEBU_1211 6,93 0 15,13 lod 4,7411 11
Bourran2_2014_nSecLBD_A4 Qrob_Chr07 7 v_8327_222 s_1A4WGY_363 16,04 0 44,69 lod 2,6373 6,5
Bourran2_2014_nP_A4 Qrob_Chr11 11 s_1B58GB_1413 s_1A5BYY_1671 11,15 0 42,38 lod 1,8913 4,5
Bourran2_2014_nP_3P Qrob_Chr11 11 v_11486_194 s_1AT3E_2335 7,9 0,09 30,09 lod 2,3636 5
Bourran2_2015_nEpis_A4 Qrob_Chr09 9 v_15847_485 v_8329_369 34,94 34,88 37,45 lod 3.1 7
Bourran2_2015_nEpiBC_A4 Qrob_Chr07 7 s_1DP9TW_798 v_8128_173 22,61 22,14 22,73 lod 3.1 8.5
Bourran2_2014_nEpiBC_A4 Qrob_Chr07 7 s_2FI9D9_500 s_1AXDMJ_325 12,26 0 34,9 lod 2,2306 6,1
Bourran2_2014_nPriBD_3P Qrob_Chr11 11 v_11486_194 s_1AT3E_2335 5,54 0,4 20,6 lod 2,6345 5,9
Bourran2_2002_QTL10_peak_Bud_burst_3P Qrob_Chr07 7 s_1CAWP_311 s_1BEZ9M_461 7,5 0 21,5 lod 3,7 6,3
Bourran2_2014_nPriBD*_A4 Qrob_Chr07 7 s_1A7UI0_596 s_1A3H6S_352 8,02 0 20,53 lod 4,1062 10,8
Bourran2_2014_nPriLBD*_A4 Qrob_Chr07 7 s_1C6BY7_802 s_1BPEBU_1211 7,15 0 16,34 lod 3,9419 10,2

0 Targeting