| Analysis | rpsblast_cdd | Start | 233 |
| End | 398 | Strand | + |
| Length | 166 | Note | Gaps:15 |
| Hit Coverage | 78.65 | Hit Length | 192 |
| Hit Pident | 56.95 | E Val | 2e-63 |
| Hit Description | cd06147 Rrp6p_like_exo DEDDy 3'-5' exonuclease domain of yeast Rrp6p human polymyositis/scleroderma autoantigen 100kDa and similar proteins. Yeast Rrp6p and its human homolog the polymyositis/scleroderma autoantigen 100kDa (PM/Scl-100) are exosome-associated proteins involved in the degradation and processing of precursors to stable RNAs. Both proteins contain a DEDDy-type DnaQ-like 3'-5' exonuclease domain possessing three conserved sequence motifs termed ExoI ExoII and ExoIII with a specific YX(3)D pattern at ExoIII. The motifs are clustered around the active site and contain four conserved acidic residues that serve as ligands for the two metal ions required for catalysis. PM/Scl-100 an autoantigen present in the nucleolar compartment of the cell reacts with autoantibodies produced by about 50% of patients with polymyositis-scleroderma overlap syndrome. | Hit Pcons | 13.91 |
| Name | Qrob_P0120240.2 |
| Protein Identifier |
Organism . Name |
Score | Score Type | Protein Description | Alias (in v1) | Code Enzyme | Gene Prediction Quality |
|---|---|---|---|---|---|---|---|
| Qrob_P0120240.2 | Quercus robur | 100.0 | egn | (M=1) K12591 - exosome complex exonuclease RRP6 [EC:3.1.13.-] | validated |
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