Protein : Qrob_P0035690.2 Q. robur
Protein Identifier  ? Qrob_P0035690.2 Organism . Name  Quercus robur
Score  21.1 Score Type  egn
Protein Description  (M=1) PF00078//PF13456//PF13966 - Reverse transcriptase (RNA-dependent DNA polymerase) // Reverse transcriptase-like // zinc-binding in reverse transcriptase Code Enzyme  EC:2.7.7.49
Gene Prediction Quality  validated Protein length 

Sequence

Length: 565  
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0 Synonyms

2 GO Terms

Identifier Name Description
GO:0003676 nucleic acid binding Interacting selectively and non-covalently with any nucleic acid.
GO:0004523 RNA-DNA hybrid ribonuclease activity Catalysis of the endonucleolytic cleavage of RNA in RNA-DNA hybrids to 5'-phosphomonoesters.

15 Blast

Analysis Hit Start End Strand Length Note Hit Coverage Hit Length Hit Pident E Val Hit Description
blastp_kegg lcl|tcc:TCM_015876 169 523 + 355 Gaps:26 96.93 391 29.82 4e-47 Non-LTR retroelement reverse transcriptase
blastp_kegg lcl|cit:102627523 170 557 + 388 Gaps:27 71.18 569 29.38 2e-46 putative ribonuclease H protein At1g65750-like
blastp_kegg lcl|brp:103874889 25 557 + 533 Gaps:26 44.85 1204 31.85 1e-45 putative ribonuclease H protein At1g65750
blastp_kegg lcl|brp:103828135 24 557 + 534 Gaps:30 45.99 1235 30.46 6e-45 putative ribonuclease H protein At1g65750
blastp_kegg lcl|brp:103849222 24 520 + 497 Gaps:30 51.24 1011 33.01 7e-44 putative ribonuclease H protein At1g65750
blastp_kegg lcl|tcc:TCM_017273 168 557 + 390 Gaps:31 62.58 660 25.67 2e-43 Ribonuclease H protein
blastp_kegg lcl|brp:103841500 24 520 + 497 Gaps:30 66.24 782 32.63 1e-42 putative ribonuclease H protein At1g65750
blastp_kegg lcl|brp:103868641 169 557 + 389 Gaps:26 91.29 448 27.14 1e-42 putative ribonuclease H protein At1g65750
blastp_kegg lcl|pmum:103336042 191 555 + 365 Gaps:25 96.95 394 27.49 1e-42 putative ribonuclease H protein At1g65750
blastp_kegg lcl|brp:103833563 198 557 + 360 Gaps:26 91.35 416 27.63 2e-42 putative ribonuclease H protein At1g65750
blastp_uniprot_sprot sp|P0C2F6|RNHX1_ARATH 102 557 + 456 Gaps:30 77.10 620 31.17 1e-44 Putative ribonuclease H protein At1g65750 OS Arabidopsis thaliana GN At1g65750 PE 3 SV 1
rpsblast_cdd gnl|CDD|187690 401 524 + 124 Gaps:1 100.00 123 39.84 1e-26 cd06222 RNase_H RNase H is an endonuclease that cleaves the RNA strand of an RNA/DNA hybrid in a sequence non-specific manner. Ribonuclease H (RNase H) enzymes are divided into two major families Type 1 and Type 2 based on amino acid sequence similarities and biochemical properties. RNase H is an endonuclease that cleaves the RNA strand of an RNA/DNA hybrid in a sequence non-specific manner in the presence of divalent cations. RNase H is widely present in various organisms including bacteria archaea and eukaryotes. Most prokaryotic and eukaryotic genomes contain multiple RNase H genes. Despite the lack of amino acid sequence homology Type 1 and type 2 RNase H share a main-chain fold and steric configurations of the four acidic active-site residues and have the same catalytic mechanism and functions in cells. RNase H is involved in DNA replication repair and transcription. One of the important functions of RNase H is to remove Okazaki fragments during DNA replication. RNase H inhibitors have been explored as an anti-HIV drug target because RNase H inactivation inhibits reverse transcription.
rpsblast_cdd gnl|CDD|205634 438 526 + 89 Gaps:1 100.00 88 29.55 1e-13 pfam13456 RVT_3 Reverse transcriptase-like. This domain is found in plants and appears to be part of a retrotransposon.
rpsblast_cdd gnl|CDD|30676 398 525 + 128 Gaps:17 91.56 154 27.66 3e-09 COG0328 RnhA Ribonuclease HI [DNA replication recombination and repair].
rpsblast_cdd gnl|CDD|206136 224 311 + 88 Gaps:6 97.67 86 38.10 6e-09 pfam13966 zf-RVT zinc-binding in reverse transcriptase. This domain would appear to be a zinc-binding region of a putative reverse transcriptase.

11 Domain Motifs

Analysis Begin End Length Domain Identifier Cross Ref Description Inter Pro
ProSiteProfiles 394 525 132 PS50879 none RNase H domain profile. IPR002156
PANTHER 21 166 146 PTHR19446:SF230 none none none
Pfam 24 103 80 PF00078 none Reverse transcriptase (RNA-dependent DNA polymerase) IPR000477
Phobius 364 564 201 CYTOPLASMIC_DOMAIN none Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm. none
Pfam 440 524 85 PF13456 none Reverse transcriptase-like none
Gene3D 398 528 131 G3DSA:3.30.420.10 none none IPR012337
SUPERFAMILY 397 526 130 SSF53098 none none IPR012337
Pfam 224 311 88 PF13966 none zinc-binding in reverse transcriptase IPR026960
Phobius 1 344 344 NON_CYTOPLASMIC_DOMAIN none Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region. none
PANTHER 21 166 146 PTHR19446 none none none
Phobius 345 363 19 TRANSMEMBRANE none Region of a membrane-bound protein predicted to be embedded in the membrane. none

0 Localization

18 Qtllist

Qtl Name Chromosome Name Linkage Group Prox Marker Dist Marker Position QTL Pos One Pos Two Test Type Test Value R 2
Champenoux_2015_nPriLBD_3P Qrob_Chr10 10 v_15000_157 v_15000_310 15,68 15,9 15,91 lod 2.4 5.5
Bourran2_2014_nSecLBD_3P Qrob_Chr08 8 s_1BN2OD_551 s_1B5AYF_599 17,17 0 43,51 lod 1,9229 4,4
Bourran2_2014_nLBD*_3P Qrob_Chr08 8 v_5216_549 v_11837_70 12,25 0 35,55 lod 2,5951 6
Bourran2_2014_nP*_3P Qrob_Chr08 8 v_5216_549 v_11837_70 12,19 0 31,97 lod 2,8472 6
Bourran2_2002_QTL11_peak_Bud_burst_A4 Qrob_Chr06 6 s_1C41PA_791 s_1AM1AV_1141 19,17 0 34,57 lod 2,3 2,9
Bourran2_2014_aSeqBC_3P Qrob_Chr06 6 v_506_189 v_686_77 30,72 13,58 43,48 lod 2,2746 6,3
Bourran2_2014_aSeqBC*_A4 Qrob_Chr06 6 s_2F5MK3_712 v_444_355 27,13 14,86 39,46 lod 3,7847 9,8
Bourran2_2014_nEpis*_3P Qrob_Chr08 8 s_1DA4QW_688 s_1DNI7D_820 17,96 0 37,75 lod 2,9745 7,5
Bourran2_2014_nEpis*_A4 Qrob_Chr07 7 v_12400_446 s_1BPEBU_1211 6,93 0 15,13 lod 4,7411 11
Bourran2_2014_nFork*_3P Qrob_Chr06 6 v_12930_125 s_1AMZEI_909 34,28 7,43 41,48 lod 2,4044 5,5
Bourran2_2014_nLBD_A4 Qrob_Chr06 6 v_12930_125 s_1AMZEI_909 37,41 9,8 50,1 lod 1,9524 4,1
Bourran2_2014_nPriBD_A4 Qrob_Chr06 6 v_12930_125 s_1AMZEI_909 34,51 3,36 51,86 lod 1,6747 3,9
Bourran2_2014_nPriLBD*_3P Qrob_Chr11 11 v_12066_307 s_1B15GJ_447 3,37 0,57 16,17 lod 3,4299 6,9
Bourran2_2014_nSecLBD_A4 Qrob_Chr07 7 v_8327_222 s_1A4WGY_363 16,04 0 44,69 lod 2,6373 6,5
Bourran2_2014_vEpiBC_A4 Qrob_Chr06 6 v_12930_125 s_1AMZEI_909 37,55 14,41 50,01 lod 1,7882 4,8
Champenoux_2015_nEpis_3P Qrob_Chr11 11 s_1DG9PM_867 s_1BZ083_1312 26,53 25,47 27,72 lod 4.4 8.9
Champenoux_2015_nP_3P Qrob_Chr06 6 s_1A386O_228 s_1AYZFS_603 27,03 26,47 27,34 lod 2.8 7.2
Bourran2_2014_nPriBD*_3P Qrob_Chr06 6 s_1B6WLL_980 v_10064_133 11,49 0 31,52 lod 4,1208 9,1

1 Targeting

Analysis Start End Length Location Reliability Signal Peptide Cut Off Mitochondrion Cut Off Network Signal Peptide Length
TargetP 1 40   Secretory pathway 4 0.675 0.095 NON-PLANT 40