GO Term : GO:1990265 platelet-derived growth factor complex GO

Namespace  cellular_component Obsolete  false
description  A protein complex consisting of two chains of platelet-derived growth factor (PDGF) subunits. PDGF dimers bind to PDGF receptors in the plasma membrane and induce receptor dimerisation and activation. PDGFs are involved in a wide variety of signalling processes. PDGFs are found in all vertebrates where at least 2 different chains (A and B) exist. In human (and other mammals), four types of PDGF chains (A, B, C, and D) are known which form five different dimers (AA, AB, BB, CC and DD).

0 Cross References

1 Ontology

Name
GO

5 Parents

Identifier Name Description
GO:0043234 protein complex A stable macromolecular complex composed (only) of two or more polypeptide subunits along with any covalently attached molecules (such as lipid anchors or oligosaccharide) or non-protein prosthetic groups (such as nucleotides or metal ions). Prosthetic group in this context refers to a tightly bound cofactor. The component polypeptide subunits may be identical.
GO:0032991 macromolecular complex A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which the constituent parts function together.
GO:0005575 cellular_component The part of a cell or its extracellular environment in which a gene product is located. A gene product may be located in one or more parts of a cell and its location may be as specific as a particular macromolecular complex, that is, a stable, persistent association of macromolecules that function together.
GO:0036454 growth factor complex A protein complex that has growth factor activity.
GO:1990265 platelet-derived growth factor complex A protein complex consisting of two chains of platelet-derived growth factor (PDGF) subunits. PDGF dimers bind to PDGF receptors in the plasma membrane and induce receptor dimerisation and activation. PDGFs are involved in a wide variety of signalling processes. PDGFs are found in all vertebrates where at least 2 different chains (A and B) exist. In human (and other mammals), four types of PDGF chains (A, B, C, and D) are known which form five different dimers (AA, AB, BB, CC and DD).

0 Protein

4 Relations

Relationship
Parent Term . Identifier

Child Term . Identifier
is_a GO:0036454 GO:1990265
is_a GO:0043234 GO:1990265
is_a GO:0005575 GO:1990265
is_a GO:0032991 GO:1990265

6 Synonyms

Name Type
PDGF-DD dimer synonym
PDGF-CC dimer synonym
PDGF-BB dimer synonym
PDGF-AB dimer synonym
PDGF complex synonym
PDGF-AA dimer synonym