GO Term : GO:0043626 PCNA complex GO

Namespace  cellular_component Obsolete  false
description  A protein complex composed of three identical PCNA monomers, each comprising two similar domains, which are joined in a head-to-tail arrangement to form a homotrimer. Forms a ring-like structure in solution, with a central hole sufficiently large to accommodate the double helix of DNA. Originally characterized as a DNA sliding clamp for replicative DNA polymerases and as an essential component of the replisome, and has also been shown to be involved in other processes including Okazaki fragment processing, DNA repair, translesion DNA synthesis, DNA methylation, chromatin remodeling and cell cycle regulation.

0 Cross References

1 Ontology

Name
GO

9 Parents

Identifier Name Description
GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm.
GO:0043234 protein complex A stable macromolecular complex composed (only) of two or more polypeptide subunits along with any covalently attached molecules (such as lipid anchors or oligosaccharide) or non-protein prosthetic groups (such as nucleotides or metal ions). Prosthetic group in this context refers to a tightly bound cofactor. The component polypeptide subunits may be identical.
GO:0044424 intracellular part Any constituent part of the living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm.
GO:0005623 cell The basic structural and functional unit of all organisms. Includes the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope.
GO:0032991 macromolecular complex A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which the constituent parts function together.
GO:0044464 cell part Any constituent part of a cell, the basic structural and functional unit of all organisms.
GO:0005575 cellular_component The part of a cell or its extracellular environment in which a gene product is located. A gene product may be located in one or more parts of a cell and its location may be as specific as a particular macromolecular complex, that is, a stable, persistent association of macromolecules that function together.
GO:0043626 PCNA complex A protein complex composed of three identical PCNA monomers, each comprising two similar domains, which are joined in a head-to-tail arrangement to form a homotrimer. Forms a ring-like structure in solution, with a central hole sufficiently large to accommodate the double helix of DNA. Originally characterized as a DNA sliding clamp for replicative DNA polymerases and as an essential component of the replisome, and has also been shown to be involved in other processes including Okazaki fragment processing, DNA repair, translesion DNA synthesis, DNA methylation, chromatin remodeling and cell cycle regulation.
GO:0044796 DNA polymerase processivity factor complex A protein complex which is capable of increasing the processivity of nucleotide polymerization by DNA polymerase as a part of DNA replication.

0 Protein

10 Relations

Relationship
Parent Term . Identifier

Child Term . Identifier
is_a GO:0044796 GO:0043626
part of GO:0044464 GO:0043626
is_a GO:0043234 GO:0043626
is_a GO:0044464 GO:0043626
is_a GO:0005575 GO:0043626
part of GO:0005622 GO:0043626
is_a GO:0044424 GO:0043626
is_a GO:0032991 GO:0043626
part of GO:0005575 GO:0043626
part of GO:0005623 GO:0043626

3 Synonyms

Name Type
PCNA homotrimer synonym
proliferating cell nuclear antigen complex synonym
sliding clamp synonym