GO Term : GO:0043223 cytoplasmic SCF ubiquitin ligase complex GO

Namespace  cellular_component Obsolete  false
description  A ubiquitin ligase complex, located in the cytoplasm, in which a cullin from the Cul1 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by a Skp1 adaptor and an F-box protein. SCF complexes are involved in targeting proteins for degradation by the proteasome. The best characterized complexes are those from yeast and mammals (with core subunits named Cdc53/Cul1, Rbx1/Hrt1/Roc1).

0 Cross References

1 Ontology

Name
GO

16 Parents

Identifier Name Description
GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm.
GO:0043234 protein complex A stable macromolecular complex composed (only) of two or more polypeptide subunits along with any covalently attached molecules (such as lipid anchors or oligosaccharide) or non-protein prosthetic groups (such as nucleotides or metal ions). Prosthetic group in this context refers to a tightly bound cofactor. The component polypeptide subunits may be identical.
GO:0031461 cullin-RING ubiquitin ligase complex Any ubiquitin ligase complex in which the catalytic core consists of a member of the cullin family and a RING domain protein; the core is associated with one or more additional proteins that confer substrate specificity.
GO:1902494 catalytic complex A protein complex which is capable of catalytic activity.
GO:0044424 intracellular part Any constituent part of the living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm.
GO:0005623 cell The basic structural and functional unit of all organisms. Includes the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope.
GO:0032991 macromolecular complex A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which the constituent parts function together.
GO:0044464 cell part Any constituent part of a cell, the basic structural and functional unit of all organisms.
GO:0005575 cellular_component The part of a cell or its extracellular environment in which a gene product is located. A gene product may be located in one or more parts of a cell and its location may be as specific as a particular macromolecular complex, that is, a stable, persistent association of macromolecules that function together.
GO:0044444 cytoplasmic part Any constituent part of the cytoplasm, all of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
GO:1990234 transferase complex A protein complex capable of catalyzing the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor).
GO:0000151 ubiquitin ligase complex A protein complex that includes a ubiquitin-protein ligase and other proteins that may confer substrate specificity on the complex.
GO:0000153 cytoplasmic ubiquitin ligase complex A ubiquitin ligase complex found in the cytoplasm.
GO:0019005 SCF ubiquitin ligase complex A ubiquitin ligase complex in which a cullin from the Cul1 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by a Skp1 adaptor and an F-box protein. SCF complexes are involved in targeting proteins for degradation by the proteasome. The best characterized complexes are those from yeast and mammals (with core subunits named Cdc53/Cul1, Rbx1/Hrt1/Roc1).
GO:0043223 cytoplasmic SCF ubiquitin ligase complex A ubiquitin ligase complex, located in the cytoplasm, in which a cullin from the Cul1 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by a Skp1 adaptor and an F-box protein. SCF complexes are involved in targeting proteins for degradation by the proteasome. The best characterized complexes are those from yeast and mammals (with core subunits named Cdc53/Cul1, Rbx1/Hrt1/Roc1).

0 Protein

18 Relations

Relationship
Parent Term . Identifier

Child Term . Identifier
is_a GO:0019005 GO:0043223
is_a GO:0000153 GO:0043223
part of GO:0005737 GO:0043223
is_a GO:0031461 GO:0043223
is_a GO:0044424 GO:0043223
is_a GO:1990234 GO:0043223
is_a GO:0043234 GO:0043223
part of GO:0044424 GO:0043223
part of GO:0005575 GO:0043223
is_a GO:0032991 GO:0043223
is_a GO:0044444 GO:0043223
part of GO:0044464 GO:0043223
is_a GO:1902494 GO:0043223
is_a GO:0044464 GO:0043223
is_a GO:0005575 GO:0043223
part of GO:0005622 GO:0043223
part of GO:0005623 GO:0043223
is_a GO:0000151 GO:0043223

3 Synonyms

Name Type
cytoplasmic cullin complex synonym
cytoplasmic SCF complex synonym
cytoplasmic Skp1/Cul1/F-box protein complex synonym