GO Term : GO:0006616 SRP-dependent cotranslational protein targeting to membrane, translocation GO

Namespace  biological_process Obsolete  false
description  The process during cotranslational membrane targeting wherein proteins move across a membrane. SRP and its receptor initiate the transfer of the nascent chain across the endoplasmic reticulum (ER) membrane; they then dissociate from the chain, which is transferred to a set of transmembrane proteins, collectively called the translocon. Once the nascent chain translocon complex is assembled, the elongating chain passes directly from the large ribosomal subunit into the centers of the translocon, a protein-lined channel within the membrane. The growing chain is never exposed to the cytosol and does not fold until it reaches the ER lumen.

0 Cross References

1 Ontology

Name
GO

42 Parents

Identifier Name Description
GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell.
GO:0055085 transmembrane transport The process in which a solute is transported from one side of a membrane to the other.
GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore.
GO:0015031 protein transport The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
GO:0006605 protein targeting The process of targeting specific proteins to particular membrane-bounded subcellular organelles. Usually requires an organelle specific protein sequence motif.
GO:0006614 SRP-dependent cotranslational protein targeting to membrane The targeting of proteins to a membrane that occurs during translation and is dependent upon two key components, the signal-recognition particle (SRP) and the SRP receptor. SRP is a cytosolic particle that transiently binds to the endoplasmic reticulum (ER) signal sequence in a nascent protein, to the large ribosomal unit, and to the SRP receptor in the ER membrane.
GO:0046907 intracellular transport The directed movement of substances within a cell.
GO:1902578 single-organism localization A localization which involves only one organism.
GO:1902580 single-organism cellular localization A cellular localization which involves only one organism.
GO:0044699 single-organism process A biological process that involves only one organism.
GO:0009987 cellular process Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.
GO:0051641 cellular localization A localization process that takes place at the cellular level; as a result of a cellular localization process, a substance or cellular entity, such as a protein complex or organelle, is transported to, and/or maintained in, a specific location within or in the membrane of a cell.
GO:0016043 cellular component organization A process that results in the assembly, arrangement of constituent parts, or disassembly of a cellular component.
GO:0071840 cellular component organization or biogenesis A process that results in the biosynthesis of constituent macromolecules, assembly, arrangement of constituent parts, or disassembly of a cellular component.
GO:0008150 biological_process Any process specifically pertinent to the functioning of integrated living units: cells, tissues, organs, and organisms. A process is a collection of molecular events with a defined beginning and end.
GO:0051179 localization Any process in which a cell, a substance, or a cellular entity, such as a protein complex or organelle, is transported to or maintained in a specific location.
GO:0044763 single-organism cellular process Any process that is carried out at the cellular level, occurring within a single organism.
GO:0044765 single-organism transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore, involving a single organism.
GO:0071702 organic substance transport The directed movement of organic substances into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore. An organic substance is a molecular entity that contains carbon.
GO:0051234 establishment of localization The directed movement of a cell, substance or cellular entity, such as a protein complex or organelle, to a specific location.
GO:0016482 cytoplasmic transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, or within the cytoplasm of a cell.
GO:0033365 protein localization to organelle A process in which a protein is transported to, or maintained in, a location within an organelle.
GO:0045184 establishment of protein localization The directed movement of a protein to a specific location.
GO:0008104 protein localization Any process in which a protein is transported to, or maintained in, a specific location.
GO:0070727 cellular macromolecule localization Any process in which a macromolecule is transported to, and/or maintained in, a specific location at the level of a cell. Localization at the cellular level encompasses movement within the cell, from within the cell to the cell surface, or from one location to another at the surface of a cell.
GO:1902582 single-organism intracellular transport An intracellular transport which involves only one organism.
GO:0072594 establishment of protein localization to organelle The directed movement of a protein to a specific location on or in an organelle. Encompasses establishment of localization in the membrane or lumen of a membrane-bounded organelle.
GO:0051649 establishment of localization in cell The directed movement of a substance or cellular entity, such as a protein complex or organelle, to a specific location within, or in the membrane of, a cell.
GO:0034613 cellular protein localization Any process in which a protein is transported to, and/or maintained in, a specific location at the level of a cell. Localization at the cellular level encompasses movement within the cell, from within the cell to the cell surface, or from one location to another at the surface of a cell.
GO:0033036 macromolecule localization Any process in which a macromolecule is transported to, or maintained in, a specific location.

0 Protein

59 Relations

Relationship
Parent Term . Identifier

Child Term . Identifier
is_a GO:0065002 GO:0006616
part of GO:0006614 GO:0006616
is_a GO:0008104 GO:0006616
part of GO:0051179 GO:0006616
part of GO:0061024 GO:0006616
is_a GO:0046907 GO:0006616
is_a GO:0051649 GO:0006616
is_a GO:0015031 GO:0006616
part of GO:0044699 GO:0006616
part of GO:0015031 GO:0006616
part of GO:0006613 GO:0006616
part of GO:0006612 GO:0006616
part of GO:0051641 GO:0006616
part of GO:0072657 GO:0006616
is_a GO:0051179 GO:0006616
is_a GO:0033036 GO:0006616
is_a GO:0044699 GO:0006616
part of GO:0071840 GO:0006616
part of GO:0046907 GO:0006616
part of GO:0033036 GO:0006616
part of GO:1902578 GO:0006616
part of GO:0006605 GO:0006616
part of GO:0090150 GO:0006616
part of GO:1902582 GO:0006616
is_a GO:0044763 GO:0006616
part of GO:1902580 GO:0006616
is_a GO:0051234 GO:0006616
part of GO:0016043 GO:0006616
part of GO:0051649 GO:0006616
part of GO:0072599 GO:0006616

4 Synonyms

Name Type
SRP-dependent cotranslational protein-membrane targeting, translocation synonym
translocation during SRP-dependent cotranslational protein targeting to membrane synonym
SRP-dependent cotranslational membrane targeting, translocation synonym
ER translocation synonym