GO Term : GO:0005834 heterotrimeric G-protein complex GO

Namespace  cellular_component Obsolete  false
description  Any of a family of heterotrimeric GTP-binding and hydrolyzing proteins; they belong to a superfamily of GTPases that includes monomeric proteins such as EF-Tu and RAS. Heterotrimeric G-proteins consist of three subunits; the alpha subunit contains the guanine nucleotide binding site and possesses GTPase activity; the beta and gamma subunits are tightly associated and function as a beta-gamma heterodimer; extrinsic plasma membrane proteins (cytoplasmic face) that function as a complex to transduce signals from G-protein coupled receptors to an effector protein.

0 Cross References

1 Ontology

Name
GO

22 Parents

Identifier Name Description
GO:0016020 membrane A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm.
GO:0005886 plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
GO:0043234 protein complex A stable macromolecular complex composed (only) of two or more polypeptide subunits along with any covalently attached molecules (such as lipid anchors or oligosaccharide) or non-protein prosthetic groups (such as nucleotides or metal ions). Prosthetic group in this context refers to a tightly bound cofactor. The component polypeptide subunits may be identical.
GO:0019898 extrinsic component of membrane The component of a membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region.
GO:1902494 catalytic complex A protein complex which is capable of catalytic activity.
GO:0044424 intracellular part Any constituent part of the living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm.
GO:0005623 cell The basic structural and functional unit of all organisms. Includes the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope.
GO:0032991 macromolecular complex A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which the constituent parts function together.
GO:0044464 cell part Any constituent part of a cell, the basic structural and functional unit of all organisms.
GO:0005575 cellular_component The part of a cell or its extracellular environment in which a gene product is located. A gene product may be located in one or more parts of a cell and its location may be as specific as a particular macromolecular complex, that is, a stable, persistent association of macromolecules that function together.
GO:0071944 cell periphery The part of a cell encompassing the cell cortex, the plasma membrane, and any external encapsulating structures.
GO:0098796 membrane protein complex Any protein complex that is part of a membrane.
GO:0044425 membrane part Any constituent part of a membrane, a double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins.
GO:0098797 plasma membrane protein complex Any protein complex that is part of the plasma membrane.
GO:0044459 plasma membrane part Any constituent part of the plasma membrane, the membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
GO:0005834 heterotrimeric G-protein complex Any of a family of heterotrimeric GTP-binding and hydrolyzing proteins; they belong to a superfamily of GTPases that includes monomeric proteins such as EF-Tu and RAS. Heterotrimeric G-proteins consist of three subunits; the alpha subunit contains the guanine nucleotide binding site and possesses GTPase activity; the beta and gamma subunits are tightly associated and function as a beta-gamma heterodimer; extrinsic plasma membrane proteins (cytoplasmic face) that function as a complex to transduce signals from G-protein coupled receptors to an effector protein.
GO:0031234 extrinsic component of cytoplasmic side of plasma membrane The component of a plasma membrane consisting of gene products and protein complexes that are loosely bound to its cytoplasmic surface, but not integrated into the hydrophobic region.
GO:0019897 extrinsic component of plasma membrane The component of a plasma membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region.
GO:0009898 cytoplasmic side of plasma membrane The leaflet the plasma membrane that faces the cytoplasm and any proteins embedded or anchored in it or attached to its surface.
GO:0098562 cytoplasmic side of membrane The side of a membrane that faces the cytoplasm.
GO:0098552 side of membrane A cellular component consisting of one leaflet of a membrane bilayer and any proteins embedded or anchored in it or attached to its surface.

0 Protein

26 Relations

Relationship
Parent Term . Identifier

Child Term . Identifier
is_a GO:0044424 GO:0005834
is_a GO:0098797 GO:0005834
is_a GO:1902494 GO:0005834
part of GO:0031234 GO:0005834
is_a GO:0098796 GO:0005834
part of GO:0019897 GO:0005834
part of GO:0019898 GO:0005834
part of GO:0044464 GO:0005834
part of GO:0016020 GO:0005834
is_a GO:0044464 GO:0005834
is_a GO:0044425 GO:0005834
is_a GO:0032991 GO:0005834
is_a GO:0044459 GO:0005834
is_a GO:0043234 GO:0005834
part of GO:0009898 GO:0005834
part of GO:0044459 GO:0005834
part of GO:0005575 GO:0005834
is_a GO:0005575 GO:0005834
part of GO:0005886 GO:0005834
part of GO:0044424 GO:0005834
part of GO:0071944 GO:0005834
part of GO:0098562 GO:0005834
part of GO:0098552 GO:0005834
part of GO:0044425 GO:0005834
part of GO:0005623 GO:0005834
part of GO:0005622 GO:0005834

4 Synonyms

Name Type
heterotrimeric G-protein GTPase, gamma-subunit synonym
heterotrimeric G-protein GTPase, alpha-subunit synonym
heterotrimeric G-protein GTPase activity synonym
heterotrimeric G-protein GTPase, beta-subunit synonym