GO Term : GO:0004512 inositol-3-phosphate synthase activity GO

Namespace  molecular_function Obsolete  false
description  Catalysis of the reaction: D-glucose 6-phosphate = 1D-myo-inositol 3-phosphate. This reaction requires NAD, which dehydrogenates the CHOH group to CO at C-5 of the glucose 6-phosphate, making C-6 into an active methylene, able to condense with the aldehyde at C-1. Finally, the enzyme-bound NADH reconverts C-5 into the CHOH form.

0 Cross References

1 Ontology

Name
GO

5 Parents

Identifier Name Description
GO:0003824 catalytic activity Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic.
GO:0016853 isomerase activity Catalysis of the geometric or structural changes within one molecule. Isomerase is the systematic name for any enzyme of EC class 5.
GO:0016872 intramolecular lyase activity The catalysis of certain rearrangements of a molecule to break or form a ring.
GO:0004512 inositol-3-phosphate synthase activity Catalysis of the reaction: D-glucose 6-phosphate = 1D-myo-inositol 3-phosphate. This reaction requires NAD, which dehydrogenates the CHOH group to CO at C-5 of the glucose 6-phosphate, making C-6 into an active methylene, able to condense with the aldehyde at C-1. Finally, the enzyme-bound NADH reconverts C-5 into the CHOH form.
GO:0003674 molecular_function Elemental activities, such as catalysis or binding, describing the actions of a gene product at the molecular level. A given gene product may exhibit one or more molecular functions.

1 Protein

Protein Identifier
Organism . Name
Score Score Type Protein Description Alias (in v1) Code Enzyme Gene Prediction Quality
Qrob_P0183240.2 Quercus robur 100.0 egn (M=1) 5.5.1.4 - Inositol-3-phosphate synthase.   EC:5.5.1.4 validated

4 Relations

Relationship
Parent Term . Identifier

Child Term . Identifier
is_a GO:0016872 GO:0004512
is_a GO:0003824 GO:0004512
is_a GO:0003674 GO:0004512
is_a GO:0016853 GO:0004512

7 Synonyms

Name Type
glucose-6-phosphate inositol monophosphate cycloaldolase activity synonym
inositol 1-phosphate synthatase activity synonym
glucocycloaldolase activity synonym
glucose 6-phosphate cyclase activity synonym
inositol 1-phosphate synthetase activity synonym
1L-myo-inositol-1-phosphate lyase (isomerizing) synonym
D-glucose 6-phosphate cycloaldolase activity synonym