Protein : Qrob_P0611060.2 Q. robur
Protein Identifier  ? Qrob_P0611060.2 Organism . Name  Quercus robur
Score  96.2 Score Type  egn
Protein Description  (M=4) 6.3.2.12 - Dihydrofolate synthase. Code Enzyme  EC:6.3.2.12
Gene Prediction Quality  validated Protein length 

Sequence

Length: 558  
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0 Synonyms

5 GO Terms

Identifier Name Description
GO:0005524 ATP binding Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones.
GO:0009396 folic acid-containing compound biosynthetic process The chemical reactions and pathways resulting in the formation of folic acid and its derivatives.
GO:0016874 ligase activity Catalysis of the joining of two substances, or two groups within a single molecule, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate.
GO:0004326 tetrahydrofolylpolyglutamate synthase activity Catalysis of the reaction: ATP + tetrahydrofolyl-(Glu)(n) + L-glutamate = ADP + phosphate + tetrahydrofolyl-(Glu)(n+1).

36 Blast

Analysis Hit Start End Strand Length Note Hit Coverage Hit Length Hit Pident E Val Hit Description
blastp_kegg lcl|pxb:103948060 4 557 + 554 Gaps:5 98.92 555 72.50 0.0 probable dihydrofolate synthetase
blastp_kegg lcl|pmum:103333670 6 555 + 550 Gaps:5 98.02 556 73.21 0.0 dihydrofolate synthetase
blastp_kegg lcl|pxb:103958166 4 557 + 554 Gaps:5 98.92 555 72.68 0.0 probable dihydrofolate synthetase
blastp_kegg lcl|vvi:100267405 28 557 + 530 Gaps:7 97.57 536 74.00 0.0 folylpolyglutamate synthase-like
blastp_kegg lcl|mdm:103439847 4 555 + 552 Gaps:5 98.56 555 74.04 0.0 probable dihydrofolate synthetase
blastp_kegg lcl|pper:PRUPE_ppa020012mg 47 550 + 504 Gaps:5 100.00 499 75.75 0.0 hypothetical protein
blastp_kegg lcl|fve:101295861 1 557 + 557 Gaps:5 99.82 553 71.01 0.0 folylpolyglutamate synthase-like
blastp_kegg lcl|cit:102611256 1 555 + 555 Gaps:9 99.28 556 69.38 0.0 folylpolyglutamate synthase mitochondrial-like
blastp_kegg lcl|cic:CICLE_v10007115mg 33 555 + 523 Gaps:5 91.68 565 72.01 0.0 hypothetical protein
blastp_kegg lcl|pop:POPTR_0015s06150g 31 555 + 525 Gaps:14 99.22 515 72.41 0.0 hypothetical protein
blastp_pdb 1o5z_A 75 450 + 376 Gaps:42 76.92 442 39.71 1e-55 mol:protein length:442 folylpolyglutamate synthase/dihydrofolate syn
blastp_pdb 1jbw_A 45 435 + 391 Gaps:47 81.31 428 30.75 3e-36 mol:protein length:428 FOLYLPOLYGLUTAMATE SYNTHASE
blastp_pdb 1jbv_A 45 435 + 391 Gaps:47 81.31 428 30.75 3e-36 mol:protein length:428 FOLYLPOLYGLUTAMATE SYNTHASE
blastp_pdb 1fgs_A 45 435 + 391 Gaps:47 81.31 428 30.75 3e-36 mol:protein length:428 FOLYLPOLYGLUTAMATE SYNTHETASE
blastp_pdb 2gca_A 45 435 + 391 Gaps:47 81.31 428 30.46 1e-35 mol:protein length:428 Folylpolyglutamate synthase
blastp_pdb 2gc6_A 45 435 + 391 Gaps:47 81.31 428 30.17 2e-35 mol:protein length:428 Folylpolyglutamate synthase
blastp_pdb 2gc5_A 45 435 + 391 Gaps:47 81.31 428 30.17 6e-35 mol:protein length:428 Folylpolyglutamate synthase
blastp_pdb 2gcb_A 45 435 + 391 Gaps:47 81.31 428 29.89 7e-35 mol:protein length:428 Folylpolyglutamate synthase
blastp_pdb 2vos_A 75 430 + 356 Gaps:44 69.82 487 33.53 2e-26 mol:protein length:487 FOLYLPOLYGLUTAMATE SYNTHASE PROTEIN FOLC
blastp_pdb 2vor_A 75 430 + 356 Gaps:44 69.82 487 33.53 2e-26 mol:protein length:487 FOLYLPOLYGLUTAMATE SYNTHASE PROTEIN FOLC
blastp_uniprot_sprot sp|Q05865|FOLC_BACSU 75 431 + 357 Gaps:41 76.28 430 37.80 5e-52 Folylpolyglutamate synthase OS Bacillus subtilis (strain 168) GN folC PE 3 SV 2
blastp_uniprot_sprot sp|P15925|FOLC_LACCA 45 435 + 391 Gaps:47 81.31 428 30.46 4e-35 Folylpolyglutamate synthase OS Lactobacillus casei GN fgs PE 1 SV 1
blastp_uniprot_sprot sp|Q05932|FOLC_HUMAN 23 470 + 448 Gaps:143 70.02 587 33.33 3e-34 Folylpolyglutamate synthase mitochondrial OS Homo sapiens GN FPGS PE 1 SV 3
blastp_uniprot_sprot sp|Q924L9|FOLC_CRIGR 31 408 + 378 Gaps:110 61.67 587 35.08 9e-34 Folylpolyglutamate synthase mitochondrial OS Cricetulus griseus GN FPGS PE 2 SV 1
blastp_uniprot_sprot sp|A6H751|FOLC_BOVIN 23 411 + 389 Gaps:99 63.93 585 35.56 1e-33 Folylpolyglutamate synthase mitochondrial OS Bos taurus GN FPGS PE 2 SV 1
blastp_uniprot_sprot sp|P48760|FOLC_MOUSE 47 414 + 368 Gaps:92 60.31 587 33.05 4e-33 Folylpolyglutamate synthase mitochondrial OS Mus musculus GN Fpgs PE 1 SV 3
blastp_uniprot_sprot sp|Q09509|FOLC_CAEEL 72 552 + 481 Gaps:94 86.08 510 30.52 1e-32 Putative folylpolyglutamate synthase OS Caenorhabditis elegans GN F25B5.6 PE 3 SV 1
blastp_uniprot_sprot sp|Q12676|FOLD_YEAST 75 497 + 423 Gaps:52 89.23 427 30.45 2e-31 Dihydrofolate synthetase OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN FOL3 PE 1 SV 1
blastp_uniprot_sprot sp|Q9UTD0|FOLD_SCHPO 75 443 + 369 Gaps:56 79.86 417 35.44 5e-30 Probable dihydrofolate synthetase OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN fol3 PE 3 SV 1
blastp_uniprot_sprot sp|P43775|FOLC_HAEIN 75 433 + 359 Gaps:53 74.60 437 31.90 6e-30 Folylpolyglutamate synthase OS Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) GN folC PE 3 SV 1

19 Domain Motifs

Analysis Begin End Length Domain Identifier Cross Ref Description Inter Pro
SUPERFAMILY 72 369 298 SSF53623 "UniPathway:UPA00219" none IPR013221
ProSitePatterns 199 214 16 PS01012 none Folylpolyglutamate synthase signature 2. IPR018109
Phobius 1 535 535 NON_CYTOPLASMIC_DOMAIN none Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region. none
PANTHER 319 481 163 PTHR11136 "KEGG:00790+6.3.2.17","MetaCyc:PWY-2161","UniPathway:UPA00850";signature_desc=FOLYLPOLYGLUTAMATE SYNTHASE-RELATED none IPR001645
TIGRFAM 75 553 479 TIGR01499 "KEGG:00790+6.3.2.17","MetaCyc:PWY-2161","UniPathway:UPA00850" folC: bifunctional protein FolC IPR001645
Gene3D 57 368 312 G3DSA:3.40.1190.10 "UniPathway:UPA00219" none IPR013221
PANTHER 34 300 267 PTHR11136 "KEGG:00790+6.3.2.17","MetaCyc:PWY-2161","UniPathway:UPA00850";signature_desc=FOLYLPOLYGLUTAMATE SYNTHASE-RELATED none IPR001645
SUPERFAMILY 372 485 114 SSF53244 "UniPathway:UPA00219" none IPR004101
SUPERFAMILY 534 556 23 SSF53244 "UniPathway:UPA00219" none IPR004101
PANTHER 505 555 51 PTHR11136 "KEGG:00790+6.3.2.17","MetaCyc:PWY-2161","UniPathway:UPA00850";signature_desc=FOLYLPOLYGLUTAMATE SYNTHASE-RELATED none IPR001645
Pfam 97 346 250 PF08245 "UniPathway:UPA00219" Mur ligase middle domain IPR013221
PANTHER 319 481 163 PTHR11136:SF0 none none none
PANTHER 34 300 267 PTHR11136:SF0 none none none
PANTHER 505 555 51 PTHR11136:SF0 none none none
Gene3D 511 556 46 G3DSA:3.90.190.20 "UniPathway:UPA00219" none IPR004101
Gene3D 372 477 106 G3DSA:3.90.190.20 "UniPathway:UPA00219" none IPR004101
Phobius 536 555 20 TRANSMEMBRANE none Region of a membrane-bound protein predicted to be embedded in the membrane. none
ProSitePatterns 95 118 24 PS01011 none Folylpolyglutamate synthase signature 1. IPR018109
Phobius 556 557 2 CYTOPLASMIC_DOMAIN none Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm. none

0 Localization

7 Qtllist

Qtl Name Chromosome Name Linkage Group Prox Marker Dist Marker Position QTL Pos One Pos Two Test Type Test Value R 2
Bourran1_2004_QTL4_peak_Bud_burst_A4 Qrob_Chr09 9 s_1BY6BQ_440 s_1AOIKO_756 16,45 0 27,45 lod 4,5 10,6
Bourran_2000_2002_QTL7_Delta.F Qrob_Chr09 9 v_5944_442 s_1BA1PC_866 23.51 10,96 35,74 lod 4.1466 0.041
Bourran2_2004_QTL14_peak_Bud_burst_A4 Qrob_Chr09 9 s_1BY6BQ_440 s_1AOIKO_756 16,83 10,33 22,33 lod 3,8 9
Bourran2_2015_nEpis_A4 Qrob_Chr09 9 v_15847_485 v_8329_369 34,94 34,88 37,45 lod 3.1 7
Bourran2_2015_nSecLBD_A4 Qrob_Chr09 9 v_15847_485 v_8329_369 35,81 34,88 37,45 lod 4.4 10.4
Bourran_2000_2002_QTL4_Delta.F Qrob_Chr09 9 s_1C1GRV_1289 v_12080_1202 2.56 0 13,73 lod 7.4808 0.051
NancyGreenhouseCO2_2001_ambient_elevated_leaf_cellulose_QTL4_d13Cf Qrob_Chr09 9 s_1C1GRV_1289 s_1BOL3D_361 2.56 0 12,57 lod 6.9263 0.028

0 Targeting