Protein : Qrob_P0595030.2 Q. robur
Protein Identifier  ? Qrob_P0595030.2 Organism . Name  Quercus robur
Score  24.2 Score Type  egn
Protein Description  (M=20) K00025 - malate dehydrogenase [EC:1.1.1.37] Code Enzyme  EC:1.1.1.37
Gene Prediction Quality  validated Protein length 

Sequence

Length: 381  
Kegg Orthology  K00025
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0 Synonyms

9 GO Terms

Identifier Name Description
GO:0016491 oxidoreductase activity Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced.
GO:0055114 oxidation-reduction process A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons.
GO:0003824 catalytic activity Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic.
GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule.
GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP.
GO:0006108 malate metabolic process The chemical reactions and pathways involving malate, the anion of hydroxybutanedioic acid, a chiral hydroxydicarboxylic acid. The (+) enantiomer is an important intermediate in metabolism as a component of both the TCA cycle and the glyoxylate cycle.
GO:0030060 L-malate dehydrogenase activity Catalysis of the reaction: (S)-malate + NAD+ = oxaloacetate + NADH + H+.
GO:0016615 malate dehydrogenase activity Catalysis of the reversible conversion of pyruvate or oxaloacetate to malate.
GO:0019752 carboxylic acid metabolic process The chemical reactions and pathways involving carboxylic acids, any organic acid containing one or more carboxyl (COOH) groups or anions (COO-).

43 Blast

Analysis Hit Start End Strand Length Note Hit Coverage Hit Length Hit Pident E Val Hit Description
blastp_kegg lcl|csv:101221189 1 377 + 377 Gaps:14 99.73 364 79.61 0.0 malate dehydrogenase cytoplasmic-like
blastp_kegg lcl|cmo:103483128 1 377 + 377 Gaps:14 99.73 364 78.79 0.0 malate dehydrogenase cytoplasmic-like
blastp_kegg lcl|cit:102615934 1 378 + 378 Gaps:16 100.00 366 76.50 0.0 malate dehydrogenase cytoplasmic-like
blastp_kegg lcl|pxb:103953311 1 378 + 378 Gaps:16 97.34 376 75.96 0.0 malate dehydrogenase-like
blastp_kegg lcl|mdm:103435358 1 378 + 378 Gaps:16 97.34 376 76.23 0.0 malate dehydrogenase-like
blastp_kegg lcl|pxb:103932637 1 378 + 378 Gaps:16 97.34 376 75.68 0.0 malate dehydrogenase-like
blastp_kegg lcl|pxb:103932290 1 378 + 378 Gaps:16 97.34 376 76.23 0.0 malate dehydrogenase-like
blastp_kegg lcl|tcc:TCM_005626 2 379 + 378 Gaps:15 90.57 403 74.79 0.0 Lactate/malate dehydrogenase family protein isoform 1
blastp_kegg lcl|rcu:RCOM_1609380 35 378 + 344 Gaps:14 99.40 332 82.12 0.0 malate dehydrogenase putative (EC:1.1.1.37)
blastp_kegg lcl|cic:CICLE_v10021075mg 35 378 + 344 Gaps:14 99.40 332 79.70 0.0 hypothetical protein
blastp_pdb 5mdh_B 36 373 + 338 Gaps:15 97.60 333 56.31 2e-117 mol:protein length:333 MALATE DEHYDROGENASE
blastp_pdb 5mdh_A 36 373 + 338 Gaps:15 97.60 333 56.31 2e-117 mol:protein length:333 MALATE DEHYDROGENASE
blastp_pdb 4mdh_B 36 373 + 338 Gaps:15 97.31 334 56.31 2e-117 mol:protein length:334 CYTOPLASMIC MALATE DEHYDROGENASE
blastp_pdb 4mdh_A 36 373 + 338 Gaps:15 97.31 334 56.31 2e-117 mol:protein length:334 CYTOPLASMIC MALATE DEHYDROGENASE
blastp_pdb 2cvq_B 35 376 + 342 Gaps:19 98.78 327 51.39 1e-98 mol:protein length:327 Malate dehydrogenase
blastp_pdb 2cvq_A 35 376 + 342 Gaps:19 98.78 327 51.39 1e-98 mol:protein length:327 Malate dehydrogenase
blastp_pdb 1y7t_B 35 376 + 342 Gaps:19 98.78 327 51.39 1e-98 mol:protein length:327 Malate dehydrogenase
blastp_pdb 1y7t_A 35 376 + 342 Gaps:19 98.78 327 51.39 1e-98 mol:protein length:327 Malate dehydrogenase
blastp_pdb 1iz9_B 35 376 + 342 Gaps:19 98.78 327 51.39 1e-98 mol:protein length:327 MALATE DEHYDROGENASE
blastp_pdb 1iz9_A 35 376 + 342 Gaps:19 98.78 327 51.39 1e-98 mol:protein length:327 MALATE DEHYDROGENASE
blastp_uniprot_sprot sp|Q7XDC8|MDHC_ORYSJ 35 378 + 344 Gaps:14 99.40 332 75.45 7e-175 Malate dehydrogenase cytoplasmic OS Oryza sativa subsp. japonica GN Os10g0478200 PE 1 SV 3
blastp_uniprot_sprot sp|Q9FSF0|MDH_TOBAC 35 377 + 343 Gaps:14 99.10 332 75.68 2e-174 Malate dehydrogenase OS Nicotiana tabacum GN MD1 PE 1 SV 1
blastp_uniprot_sprot sp|O48905|MDHC_MEDSA 35 378 + 344 Gaps:14 99.40 332 75.15 3e-174 Malate dehydrogenase cytoplasmic OS Medicago sativa GN CMDH PE 1 SV 1
blastp_uniprot_sprot sp|Q08062|MDHC_MAIZE 35 377 + 343 Gaps:14 99.10 332 75.38 9e-174 Malate dehydrogenase cytoplasmic OS Zea mays PE 1 SV 2
blastp_uniprot_sprot sp|O24047|MDHC_MESCR 36 377 + 342 Gaps:14 98.80 332 74.09 2e-169 Malate dehydrogenase cytoplasmic OS Mesembryanthemum crystallinum GN MDH PE 2 SV 1
blastp_uniprot_sprot sp|P93819|MDHC1_ARATH 35 378 + 344 Gaps:14 99.40 332 74.55 2e-169 Malate dehydrogenase cytoplasmic 1 OS Arabidopsis thaliana GN At1g04410 PE 1 SV 2
blastp_uniprot_sprot sp|P57106|MDHC2_ARATH 35 378 + 344 Gaps:14 99.40 332 74.24 5e-169 Malate dehydrogenase cytoplasmic 2 OS Arabidopsis thaliana GN At5g43330 PE 2 SV 1
blastp_uniprot_sprot sp|Q9SML8|MDHC_BETVU 36 377 + 342 Gaps:14 98.80 332 73.17 1e-167 Malate dehydrogenase cytoplasmic OS Beta vulgaris GN NR1 PE 1 SV 1
blastp_uniprot_sprot sp|P40925|MDHC_HUMAN 36 373 + 338 Gaps:15 97.31 334 56.62 2e-118 Malate dehydrogenase cytoplasmic OS Homo sapiens GN MDH1 PE 1 SV 4
blastp_uniprot_sprot sp|O88989|MDHC_RAT 36 373 + 338 Gaps:15 97.31 334 57.23 2e-117 Malate dehydrogenase cytoplasmic OS Rattus norvegicus GN Mdh1 PE 1 SV 3

14 Domain Motifs

Analysis Begin End Length Domain Identifier Cross Ref Description Inter Pro
ProSitePatterns 202 214 13 PS00068 "KEGG:00020+1.1.1.37","KEGG:00270+1.1.1.37","KEGG:00620+1.1.1.37","KEGG:00630+1.1.1.37","KEGG:00680+1.1.1.37","KEGG:00710+1.1.1.37","KEGG:00720+1.1.1.37","MetaCyc:PWY-1622","MetaCyc:PWY-5392","MetaCyc:PWY-561","MetaCyc:PWY-5690","MetaCyc:PWY-5913","MetaCyc:PWY-6728","MetaCyc:PWY-6969","MetaCyc:PWY-7115","MetaCyc:PWY-7383","Reactome:REACT_474" Malate dehydrogenase active site signature. IPR001252
Phobius 6 26 21 TRANSMEMBRANE none Region of a membrane-bound protein predicted to be embedded in the membrane. none
Phobius 27 380 354 CYTOPLASMIC_DOMAIN none Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm. none
Pfam 39 199 161 PF00056 none lactate/malate dehydrogenase, NAD binding domain IPR001236
Gene3D 36 201 166 G3DSA:3.40.50.720 none none IPR016040
Pfam 203 370 168 PF02866 none lactate/malate dehydrogenase, alpha/beta C-terminal domain IPR022383
TIGRFAM 36 371 336 TIGR01759 "KEGG:00020+1.1.1.37","KEGG:00270+1.1.1.37","KEGG:00620+1.1.1.37","KEGG:00630+1.1.1.37","KEGG:00680+1.1.1.37","KEGG:00710+1.1.1.37","KEGG:00720+1.1.1.37","MetaCyc:PWY-1622","MetaCyc:PWY-5392","MetaCyc:PWY-561","MetaCyc:PWY-5690","MetaCyc:PWY-5913","MetaCyc:PWY-6728","MetaCyc:PWY-6969","MetaCyc:PWY-7115","MetaCyc:PWY-7383" MalateDH-SF1: malate dehydrogenase IPR010945
SUPERFAMILY 203 378 176 SSF56327 none none IPR015955
Gene3D 202 377 176 G3DSA:3.90.110.10 none none IPR015955
PIRSF 34 376 343 PIRSF000102 none none IPR001557
PANTHER 35 379 345 PTHR23382 "KEGG:00020+1.1.1.37","KEGG:00270+1.1.1.37","KEGG:00620+1.1.1.37","KEGG:00630+1.1.1.37","KEGG:00680+1.1.1.37","KEGG:00710+1.1.1.37","KEGG:00720+1.1.1.37","MetaCyc:PWY-1622","MetaCyc:PWY-5392","MetaCyc:PWY-561","MetaCyc:PWY-5690","MetaCyc:PWY-5913","MetaCyc:PWY-6728","MetaCyc:PWY-6969","MetaCyc:PWY-7115","MetaCyc:PWY-7383";signature_desc=MALATE DEHYDROGENASE none IPR010945
TIGRFAM 59 373 315 TIGR01758 "KEGG:00020+1.1.1.37","KEGG:00270+1.1.1.37","KEGG:00620+1.1.1.37","KEGG:00630+1.1.1.37","KEGG:00680+1.1.1.37","KEGG:00710+1.1.1.37","KEGG:00720+1.1.1.37","MetaCyc:PWY-1622","MetaCyc:PWY-5392","MetaCyc:PWY-561","MetaCyc:PWY-5690","MetaCyc:PWY-5913","MetaCyc:PWY-6728","MetaCyc:PWY-6969","MetaCyc:PWY-7115","MetaCyc:PWY-7383" MDH_euk_cyt: malate dehydrogenase, NAD-dependent IPR011274
SUPERFAMILY 23 201 179 SSF51735 none none none
Phobius 1 5 5 NON_CYTOPLASMIC_DOMAIN none Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region. none

1 Localization

Analysis Start End Length
TMHMM 7 26 19

8 Qtllist

Qtl Name Chromosome Name Linkage Group Prox Marker Dist Marker Position QTL Pos One Pos Two Test Type Test Value R 2
Bourran2_2014_vSeqBC_3P Qrob_Chr10 10 s_1A6CK6_610 v_7092_29 4,28 0 23,27 lod 2,8619 7
Bourran2_2014_nFork*_3P Qrob_Chr06 6 v_12930_125 s_1AMZEI_909 34,28 7,43 41,48 lod 2,4044 5,5
Bourran2_2015_nSeqBC_3P Qrob_Chr11 11 s_1DG9PM_867 s_1BZ083_1312 26,06 25,47 27,72 lod 3.6 7.1
Bourran2_2015_nP_3P Qrob_Chr12 12 v_10140_295 v_838_303 16 14,69 18,01 lod 5.1 13.7
Bourran1_2004_QTL4_peak_Bud_burst_3P Qrob_Chr04 4 s_1AHUWN_1101 s_1BRNG7_1618 30,55 0 47,55 lod 2,8 7,4
Bourran2_2002_QTL10_peak_Bud_burst_A4 Qrob_Chr04 4 s_1B59MJ_737 s_1BGLSD_999 15,86 0 41,66 lod 2,8 4
Bourran1_2000_QTL3_peak_Bud_burst_3P Qrob_Chr04 4 s_1A6DJQ_418 s_1A1PEC_1268 23,09 9,09 44,09 lod 2,3 6,8
NancyGreenhouseCO2_2001_ambient_elevated_leaf_cellulose_QTL7_d13Cf Qrob_Chr04 4 s_1B91MJ_705 s_1AHIKX_640 33.92 12,11 48,31 lod 6.1865 0.023

0 Targeting